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BioWorld Science

Oct. 4, 1996

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Tachykinin antagonists disclosed by Sanofi

Potential of cannabinoid derivative in pain and inflammation

Janssen describes vasoconstrictors for migraine Rx

Merck & Co. reports 5-HT1Dalpha receptor agonists

New antiacne bacteriocin

Takeda discloses cephem antibacterial compounds

Hydroxypyridone cephalosporins described by Kyorin

Fujisawa describes orally active cephalosporin

Combined beta-lactamase inhibitor/antibacterial agent from Roche

Bridged carbacephems from Roche for use in combination with cephalosporins

Cephalosporin-bridged carbacephem combinations evaluated by Roche

P&G describes quinolonyl-cephem dithiocarbamates

Carbapenem from Merck & Co. undergoing extensive evaluation

Orally active ester-type carbapenem prodrug from Sankyo

Novel carbapenem with anti-MRSA activity from Banyu

Quinolonyl-carbapenems from P&G

Another series of multifunctional antibacterial agents from P&G

Pharmacia & Upjohn continues investigation of oxazolidinones

Magainin's lead compound effective and safe in the treatment of infection in diabetic foot ulcers

IntraBiotics' protegrins as potential treatments for multi-drug-resistant infections & gastric ulcer

Potential antitubercular agents from PathoGenesis

PathoGenesis selects nitroimidazopyran as potential tuberculosis Rx

Semisynthetic pneumocandin analogue for fungal infections

SS Pharm. & Yoshitomi developing triazole antifungal agent

BPI-derived fungicidal peptides from Xoma

Orally active cyclic depsipeptides from Schering-Plough

AmBisome licensed to Sumitomo

Antiherpesvirus agents from Eisai

Dana Farber discloses unique antiherpetic therapy

Development of ViroPharma's lead antiviral drug progresses

Sch-48973, a potent, broad-spectrum antienterovirus compound

Roche and Gilead Sciences collaborate on the development of neuraminidase inhibitors

Antiviral/corticosteroid therapy beneficial for herpes zoster

Pharmacia & Upjohn details the activity of new HIV protease inhibitor

Japanese patent coverage for NABI HIV immunotherapeutic

New agent for CMV infection from Glaxo Wellcome

Gilead Sciences issues warning regarding Vistide

More COX-2 inhibitors from Searle

Merck Frosst discloses a new series of COX-2 inhibitors

Matrix metalloproteinase inhibitors disclosed by Roche Bioscience

Mercian investigators report new antiarthritic compounds

Enzyme inhibitor for autoimmune diseases isolated by Japanese researchers

Pfizer halts U.S. development of tenidap for rheumatoid arthritis

Fournier investigates deoxyspergualin analogues

delta-Opioid antagonists for non-CNS applications

PPL Therapeutics-RPMS xenotransplantation collaboration

Protein Design Labs' humanized antibody effective in reducing kidney transplant rejection

First approval for a DTaP-IPV vaccine

Novopharm develops new recombinant form of MAb

Progenics cancer vaccine enters clinical trials

Combination therapy Maxamine/IL-2 effective in extending remission time & preventing relapse

Anticancer MMP inhibitor enters clinical trials

Inhibitors of endothelial cell proliferation from Sumitomo

Human Genome Sciences discloses novel approach to malignancy

VX-853 for MDR reversal receives patent coverage

U.S. Bioscience and Schering-Plough revise Ethyol agreement

Japanese licensing agreement for Geron's telomerase detection technology

Broad patent coverage for Sonus's ultrasound contrast agents

Promising clinical results with gastrointestinal cancer diagnostic

Antex awarded SBIR grant for diagnostic tests

Introduction of integrated test for breast and ovarian cancer ahead of schedule

Novel benzodiazepine derivatives from Roche

5-HT2B/2C antagonists disclosed by SKB

New antipsychotic agents from Janssen

Genset and Johnson & Johnson collaborate in the area of schizophrenia

Atypical antipsychotic receives approvals

Novopharm authorized to market generic Prozac in same color

MRC scientists investigate estrogen's role in psychological disorders

Aurora and ArQule drug discovery collaboration

Biogen and P&U sign agreement for protein secretion technology

ICN acquires major antibody manufacturer

Conceptus to acquire medical device company

Flamel Technologies acquires SmithKline Beecham production facility

CRO merger completed

Elan and Cytogen form new company for cancer therapeutics and diagnostics

Company Profile: PathoGenesis

Company Profile: Vion

Spanish investigators report MAO inhibitors

Genzyme-Diacrin joint venture for porcine neural cell products

Divalproex reduces cognitive deficits associated with lithium

Astra NOS inhibitors as neuroprotectants

Calpain inhibitors from Fujirebio

Schering-Plough seeks approval for corticosteroid nasal spray in rhinitis

Zeneca claims new antiasthma agents

Natural cAMP phosphodiesterase inhibitor reported by Nippon Kayaku

Glaxo Wellcome decides not to develop oral asthma treatment

Promising phase II results with APC-366

Patent coverage for serine protease inhibitors licensed to Sparta

Axiom-Zaiya CD40 research collaboration

Spotlight on LTD4 antagonists

Medeva terminates agreement with Chiesi related to dry powder inhaler

HLE inhibitors described by Zeneca

Prodesfarma presents cardiovascular candidate

TMR as adjunct to bypass surgery

Alexion authorized to begin second clinical trial with C5 inhibitor

T Cell Sciences receives grant to develop CETP vaccine

New bi-ventricular pacemaker enters clinical trials

HemoCleanse evaluates sorbent-based system in sepsis

Further patent coverage for vascular disease therapy

Interim phase II results reported for Neutralase

Joint venture formed for development of oral heparin

Boehringer Mannheim reports fibrinogen antagonists for thromboembolic conditions

Fibrinogen antagonists reported by Searle

BB-10153 development progresses

Glaxo Wellcome reports new diuretics

FDA approves IVAX drug for IC

Grant to fund phase III trial of Synsorb Pk

Clinical trial on oral H. pylori vaccine completed

Promising phase III results with treatment for ulcerative colitis

LeukoSite and Oxford Asymmetry collaboration in IBD

Roche and Gilead Sciences to copromote hepatitis treatment in the U.S.

Hepatitis A vaccine approved in Canada

Gene for hereditary pancreatitis identified

Troglitazone and Warner-Lambert/Sankyo joint venture

Shaman and Lipha to develop antidiabetic drugs

Novo Nordisk and Schering AG sign collaborative agreement for fertility drugs

New introduction for fertility hormone

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