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BioWorld Science

Nov. 8, 1996

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NK1 antagonists described by Merck & Co.

Novel tachykinin antagonists from Glaxo Wellcome

Menarini receives U.S. patent coverage for single-isomer analgesic

Lilly reports 5-HT1F agonists for migraine

Migraine-related gene discovered by Dutch researchers

Focus on present and future migraine therapy

FDA clears generic OTC product for hair regrowth

New penems from Suntory

Sankyo discloses natural antibacterial compounds

Hybridon files new patent for antisense oligonucleotides

Potent inhibitor of HSV RR subunit association selected by Bio-Mega/Boehringer Ingelheim

Northern Illinois University offers ribozyme with potential for treatment of HPV for licensing

Method for deriving ribozymes from nucleotide sequences available for licensing

Sankyo describes anti-HIV agents

HIV protease-inhibitory tetronic acids from P&U

Expanded access allowed for NTZ in AIDS patients

Novel nontoxic AIDS drug cleared for clinical trials

MiKasome cleared for clinical trials in HIV-positive patients

Procept and MRC clinical collaboration on topical microbicide

Cel-Sci reports interim results from AIDS vaccine trial

Spanish phase II trial to evaluate Remune in combination with antiviral agents

IL-2 treatment dramatically effective in AIDS patients

Antiarthritic agents with good safety reported by Toyama

Santen reports LTA4 hydrolase inhibitors

Sandoz reveals SLe(x)-mimetic compounds for treating inflammation

MMP inhibitors described by Procter & Gamble

IL-1 receptor antagonists claimed by HMR/Affymax

Progress on Scotia's rheumatoid arthritis treatment

More convenient formulation of Lodine approved

Development of antiinflammatory/analgesic drug discontinued

Bacterial meningitis virtually eliminated in U.S. following introduction of Hib vaccine

ImClone licenses NIH patent for stem cell and gene therapy

FDA advisory committee deems ACEL-IMUNE safe and effective for use in infants

ImmuLogic's Allervax products available for licensing

Debiopharm describes novel platinum complexes

IND filing for SPI-77

Meiji Seika discloses antitumor antibiotics

Novel piericidin antitumor antibiotics reported by Japanese and Chinese researchers

Univ. of Tokyo researchers identify new antitumor antibiotics

Ilex compound for malignant brain tumors licensed to Janssen

New taxane series disclosed by Indena

Hormonal agents from Yamanouchi

Apoptosis-inducing MAb from Chugai

Novel tumor vaccine claimed by Boehringer Ingelheim

Ovarian cancer vaccine enters pivotal trials in Europe

Prizm and University of Pittsburgh receive STTR grant for antimelanoma MAb

RGL protein for treatment of ras-related cancers

Preclinical results on angiogenesis inhibitor from NeXstar

New preclinical results reported for marimastat

Scotia reports progress on Foscan

Scotia's radioprotectant accepted for EMEA review

Interpore and Quantic to develop cartilage repair product

NPS and SKB extend osteoporosis research collaboration

Yamanouchi discloses hypocholesterolemic agents

Squalene synthase inhibitors reported by RPR

Phase IIb/IIc trials with CholestaGel

Federal Circuit affirms patent judgment for Amgen against Genetics Institute

Cocaine vaccine nearing clinic

MAb for diagnosis of malignant tumors

Research Triangle Institute describes high-affinity and selective ligand for dopamine transporter

Nycomed discontinues development of MRI contrast agent

American Biogenetic Sciences' blood clot diagnostic test cleared for marketing

FDA clears automated bone resorption immunoassay

5-HT1A receptor agonists from Sankyo

Yoshitomi describes compounds for anxiety and epilepsy

Scotia schizophrenia project develops rapidly

New treatment option for schizophrenia approved in Canada

Risperidone + clozapine effective in chronic schizophrenia

Nicotine analogues proposed for treatment of depression

Scherer-Merck softgel development agreement

NIU researchers offer improved vector delivery system for ribozymes

Strategic agreement between BTG and South African MRC

More on Genzyme-Neozyme II merger

Cambridge Biotech reorganization completed

Genset to form Chinese joint venture

Hemagen acquires high-technology manufacturer

Biopool to acquire business from Organon Teknika

Cypress Bioscience acquires PRP

Name change for Biomin Therapeutic

New trade name for Connaught Laboratories

FDA approval for Faulding generic anticonvulsant

ImmuLogic's MS therapeutic nearing the clinic

Mylan generic drug approved by FDA

Histamine H3 receptor ligands described by INSERM/Bioprojet

Trophix-Children's Hospital neurodegeneration research collaboration

Mitsubishi reports cathepsin B/calpain inhibitors

Taisho discloses agent for cerebrovascular disorders

Cortech announces further delays in development of Bradycor

Warner-Lambert claims NK3 antagonists with broad therapeutic applications

Natural PAF acetyltransferase inhibitor as lead antiinflammatory compound

Genzyme licenses vectors for CF gene therapy from Vical

Potential antihypertensive agents reported by Kyowa Hakko

Natural dual inhibitor of ECE and NEP described by Sankyo

Nycomed discontinues development of antihypertensive drug

Teva generic drug licensed by FDA

Teijin discloses PDGF-inhibitory agents

Antianginal and antiulcer agents from Sankyo

Development of Scotia's restenosis Rx back on track

Second-generation nitroglycerin patch submitted in Spain

Suntory's new sodium/calcium channel blockers

Potential antiischemic/antiarrhythmic agent reported

Canadian researchers claim hirudin derivative

Fujisawa claims fibrinogen antagonists

Orally active antithrombotic RGD-mimetics reported by E. Merck

Cor Therapeutics' fibrinogen receptor antagonist effective in unstable angina

Nycomed suspends development of anticlotting agent

Novel PAI-1 inhibitor discovered by Xenova

Japanese researchers report potential fibrinolytic agent

FDA clears new heart attack drug

CV Therapeutics reports novel adenosine antagonist

Synaptic, Merck extend BPH collaboration

Clinical trial program for RenaGel continues on schedule

Daiichi discloses CCK-B/gastrin receptor antagonists

Anti-H. pylori antisense oligonucleotides reported by SCRAS

Rabeprazole + amoxicillin for eradication of H. pylori

Patent coverage for new HBV treatment licensed to Vion

Approval recommended for primary biliary cirrhosis Rx

Novo Nordisk/Takeda diabetes collaboration

Scotia clarifies questions regarding its PLA dossier for Tarabetic

Little time devoted to treating male infertility in U.S.

Treatment guidelines for erectile dysfunction

Third submission for Muse

MRC to coordinate large, long-term trial of HRT

Unprecedented efficacy and safety reported for Crinone in gynecological disorders

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