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BioWorld Science

June 4, 1998

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Celltech: six-month highlights

U.S. patent to be issued for cell death gene

Company Profile: Innovir

Vical reports initial results from gene-based immunotherapy for prostate cancer

Vertex receives notice of allowance for neurophilin compounds

Myriad Genetics awarded U.S. patent for tumor suppressor gene

Harvard Scientific begins phase II trial with erectile dysfunction product

Farnesyltransferase inhibitor with potential in the treatment of glioblastoma multiforme

Minimum effective dose of licostinel determined in rat model of transient focal cerebral ischemia

Antiinvasive and antimitotic effects of marimastat assessed in vitro in brain tumors

Discovery of Aurora2 oncogene reported

AG-3340 markedly inhibits growth of malignant glioma in murine model

Advanced Corneal System seeks Vitrase approval in Mexico

Cytokine-based gene medicines described by GeneMedicine at scientific meeting

AxyS files IND for dry powder inhalation formulation of APC-366

Topiramate: clinical results in intractable epilepsy, preclinical neuroprotective effect

Genome Therapeutics and ArQule form antiinfective drug collaboration

Dopaminergic agents for schizophrenia described by AHP

Genetics Institute claims series with PLA2-inhibitory activity

Byk Gulden's new PDE IV inhibitors

Another group of CRF antagonists for stress-related disorders in development at Pfizer

More work at P&G on metalloprotease inhibitors

Neurokinin antagonists in the pipeline at Schering-Plough

U.S., European patents on Idec's gp39 program to be issued

TA-606, an orally active prodrug of the potent AII antagonist 606A

More sildenafil clinical data presented at AUA; CPMP recommends European marketing approval

FDA approves new combination therapy product for HCV

FDA gives VaxGen the go-ahead for phase III testing of AIDSVAX; trials will begin this month

APHS: a selective COX-2 inhibitor for treating inflammatory and proliferative disorders

80-90% response rate obtained with Topiglan

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