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BioWorld Science

June 22, 1999

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Role of pyruvate dehydrogenase in diabetes

News from ADA: antidiabetic efficacy of the ingredients of an animal prostate extract

New insulin preparation with improved stability for delivery via implanted pump

Retavase now available in Canada for emergency treatment of heart attacks

NN-304 is a safe and predictable insulin analogue in human studies

Draxis acquires Canadian rights to eight neurology products from Elan

Toll-like receptors implicated in septic shock

New product for anemia in hemodialysis patients now available in U.S.

Rebetol combination therapy for treatment of chronic HCV launched in Germany

New class of compounds for sickle cell disease and abnormal cell proliferation

AxyS claims heterocyclic factor Xa inhibitors

Antagonists of P2Y2 receptors designed at Astra (AstraZeneca)

New integrin receptor antagonists synthesized at DuPont

Schering-Plough scientists prepare thrombin receptor antagonists

Inhibitors of serine proteases in the pipeline at 3-D

EP-70905, a GHRP analogue with cardiovascular effects

Xenova refocuses research at MetaXen subsidiary

U.S.-Mexican team identifies FL-104, a potent and selective ERalpha ligand

DPP-IV inhibitor isoleucine thiazolidide is effective in rat model of type II diabetes

PRL-2915: a potent, subtype-selective SRIF antagonist from Biomeasure, Tulane

Nateglinide: an insulin secretagogue with significant advantages over other drugs in its class

Structure, synthesis and pharmacological activity of SIB-1553A presented by Sibia

Ziconotide use not associated with respiratory depression according to rat study

Phase III trial initiated for MRI contrast agent AngioMARK

ImmunoGen receives second milestone payment for anticancer prodrug from SmithKline Beecham

Results from first phase II trial of orally active PAF inhibitor in multiple sclerosis discouraging

Pharmacokinetic data for exendin-4 in rats presented at ENDO '99

Janssen withdraws antihistamine astemizole from the market

PRL-2903: a tool for the study of somatostatin receptors in diabetes

Anti-VEGF antibody reverses ascites associated with ovarian cancer in rodent model

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