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BioWorld Science

May 22, 2000

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Avax continues to advance on several fronts

Ophidian seeks parnterships for development programs

Benefits of Fosamax continue with long-term use

BioSante announces positive preclinical data on new vaccine adjuvant and delivery system

PDL and Toagosei collaborate on SMART anti-VEGF development

Pfizer updates late-stage product pipeline at annual meeting

DSMB recommends continuation of Theratope phase III trial

SkyePharma and Pfizer enter second drug delivery agreement

Antisense modulation of TRAF expression by new Isis compounds

New oral antisense inhibitor of TNF-alpha emerges from Isis/Elan collaboration

New stroke treatment derived from snake venom shows promise in clinical trial

Orlistat reduces progression to type II diabetes in obese adults

Oral zolmitriptan effectively improves episodic cluster headaches

NuChem selects NC-381 as lead anticancer agent

Benzazine derivatives as selective PDE4 inhibitors

New class of oxazolidinone antibacterials in the AstraZeneca pipeline

Synthesis and biological activity of new cell adhesion inhibitors described by Nihon Nohyaku

Asahi patents new series of PG derivatives

Novel organometallic compounds from MIT useful for detecting amyloid fibrils

Phenylalkanoic acid derivatives as alpha4 integrin inhibitors; use in immune, inflammatory disorders

New agents for cataracts designed by Sankyo

Beta3-adrenoceptor agonists now claimed for inhibiting uterine contractions

Dutch investigators identify potent and selective human A3 receptor antagonist

Cephalon's modafinil effective in adults with ADHD

Orally bioavailable modified anti-ICAM-1 antisense oligo and effects in rat kidney transplant models

C220, a novel chimeric anti-CD40 MAb, prolongs renal allograft survival in primates

Targeted immunosuppression of alloreactive cells achieved with OX-40 immunotoxins

Mallinckrodt's extended-release methylphenidate approved by FDA for ADHD

SERP-1: potential synergy with ciclosporin indicated by preclinical results

Nycomed Amersham designs alternatives to barium for GI imaging