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BioWorld Science

July 20, 2000

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5-HT1A receptor agonist MKC-242 has antiaggressive activity in isolated mice

Ro-60-0175 exerts differential effects in combination with antidepressants in mouse model

Photofrin approved in Sweden, Ireland and Italy

Maxim submits NDA for Maxamine

Innohep approved by FDA for DVT

Arsenic trioxide receives third orphan drug designation from FDA

Nucleotides in development at Inspire for various clinical indications

Inhibitors of fungal chitin synthase a focus of research at Roche

SM-20550 provides protection against I/R-induced skeletal muscle injury

Role of vasopressin and vasopressin antagonists in heart failure reviewed at recent congress

Centaur completes enrollment in phase IIa Parkinson's disease trial

Added benefit of ET blockade and angiotensin receptor antagonism in CHF

M-Vax now available in Australia for melanoma therapy

Emivirine may be useful for preventing perinatal transmission of HIV, as reported at AIDS conference

Micrologix Biotech advances additional products into clinical trials

HIV-1 RT dimer destabilization as a target for new antiviral agents

Potent anti-HIV activity described for human lysozyme fragments at AIDS conference

Genzyme General files MAA for approval of Fabrazyme in Europe

EMEA accepts MAA for Replagal as treatment of Fabry disease

Design and characterization of low-affinity, short-acting A2A AdoR agonists

ZymoGenetics isolates new PDGF-alpha receptor-binding polypeptide

Triazolo CCR3 receptor antagonists claimed by Toray for Rx of allergic diseases, etc.

Banyu presents new heterocyclic ORL1 receptor antagonists, their preparation and use

Indena's new colchicine derivatives active against multidrug-resistant cancer cells

K-5993: a new peptide IL-4 antagonist

Novel series of antioxidants emerges from R&D at ADIR

Novel COMT inhibitors for Parkinson's disease under study at Portela

Antisense modulators of EGR-1 expression patented by Isis

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