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BioWorld Science

Sep. 7, 2000

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Ibuprofen as effective as indomethacin in treating patent ductus arteriosus

Diltiazem and diuretic + beta-blocker display equal efficacy in hypertension trial

Ditropan XL and Detrol produce similar incidence of dry mouth

Novel approach to identifying therapeutic targets and high-affinity ligands/substrates

Discovery of potent alphavbeta3 antagonists described by Merck at ACS meeting

New phosphodiester analogue synthesized at Duke

New substituted indolealkanoic acids are potent and selective aldose reductase inhibitors

DuPont designs potent and selective factor Xa inhibitors with excellent PK profile

ACS presentation details chemistry, SAR and pharmacology of CV-1013

Elan/Wyeth-Ayerst describe SAR on series of small-molecule VLA-4/VCAM-1 inhibitors

Inhaled prostanoids + PDE inhibitors for improving therapy of pulmonary hypertension

Use of AII receptor antagonists in prevention, treatment of AMI

FDA approves ciprofloxacin for treatment of postexposure inhalational anthrax

Pharmacia's Aromasin receives clearance from Health Canada

Flavopiridol, a known antitumor agent, now reported effective in models of vascular injury

New JT compounds exert immunostimulating, antiviral and antitumor activity

Meiji Seika describes inhibitors of PARP and their use in recent patent

Compositions for pathologies associated with insulin resistance claimed by Merck KGaA

Teijin reports on new class of factor Xa inhibitors

New cinnamamide derivatives and their use described by Tsumura

Nonpeptide agonists of GLP-1 receptor presented by Novo Nordisk and Agouron

Thrombin inhibitors and their prodrugs synthesized at AstraZeneca

New heterocyclic CCR5 antagonists from Merck as leads for effective anti-HIV agents

Bone Care launches Hectorol Injection

Lundbeck and Mitsui establish citalopram collaboration agreement

Cantab finalizes DISC-HSV agreement with Glaxo Wellcome

Acquisition of Spiros by Dura now complete

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