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BioWorld Science

May 23, 2001

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First-quarter development progress reported by HGS

Hybrigenics and Lynx discover novel obesity drug target candidate

ROCK inhibitor protects against ischemia/reperfusion injury to the liver

Transplant 2001: RARalpha agonists as candidates for allograft rejection

SciClone's CPX for cystic fibrosis assigned orphan drug status in E.U.

Karo Bio licenses mechanism-based drug discovery technologies from Duke

Safety and efficacy of ISIS-2302 in preventing acute renal allograft rejection

Roche and deCODE report identification of genes linked to stroke and type 2 diabetes

Low-dose tolafentrine may improve efficacy of inhaled prostanoids in chronic PH therapy

Alliance's LiquiVent does not reach phase II/III endpoint

Small-molecule sPLA2 inhibitor appears to have beneficial effects in severe sepsis

FeRx receives go-ahead in China for phase II HCC trials with MTC-DOX

Company Profile: Viral Genomix

Long-acting insulin analogue Lantus now available in the U.S.

DDW news: high efficacy and good tolerance reported for CNI-1493 in moderate to severe CD

FDA accepts for review Roche's sNDA for new Xenical indication

Versicor begins phase II trial of novel glycopeptide antibiotic

Liver-sparing effect described for NO derivative of acetaminophen at Digestive Disease Week

Company Profile: Chemokine Therapeutics

Quorex licenses novel antibacterial targets from Burnham Institute

Development of psoriatic lesions in SCID mouse model inhibited by SB-239063

Topical R-115866 exerts retinoid activity without irritating skin

Antiarrhythmic agents from Aventis act on Kv1.5 channels

Tachykinin antagonists described in recent patent by Glaxo

Bayer presents new adenosine receptor ligands and potential therapeutic applications

Tryptase inhibitors designed by Boehringer Ingelheim

Oxazinoquinolone herpesvirus DNA polymerase inhibitors

Potent MMP inhibitors suitable for cancer therapy described by Roche team

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