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BioWorld Science

June 11, 2003

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The EP4 agonist Ono-4819 accelerates bone healing in rats

CGP-41251 demonstrates novel immunosuppressive activity

Inhibition of p38 MAPK with FR-167653 prevents the onset and progression of arthritis in rats

D-003 prevents bone loss and reduces bone resorption in ovariectomized rats

CC-5013 inhibits adhesion molecules and prevents metastasis in an animal model

Good safety profile for peginterferon alfa-2a in malignant melanoma

MEDI-522 well tolerated in patients with refractory colorectal cancer

Pfizer presents promising preclinical data for CP-690550

Halofuginone efficacy and pharmacokinetic data presented at ASCO

Evidence of antitumor effects found for endostatin in neuroendocrine tumors

Once daily NM-3 is well tolerated and has antitumor activity in advanced solid tumors

ABT-510 is well tolerated and induces antitumor response in cancer patients

Evaluation of the antiangiogenic effects of chemotherapy using dynamic MRI

Biogen/Icos LFA-1 collaboration is concluded

BioSante signs biodefense vaccine CRADA with U.S. Army

Final phase IIa results from kidney transplant study of ISA-247

ATL-1101 silences target gene in lab psoriasis studies

CHF-3381 proceeds to proof-of-concept study

Four related series of antiviral neuraminidase inhibitors reported by Biota

New alpha4 integrin antagonists and their use in IBD, asthma, arthritis, etc.

Novel glycogen phosphorylase inhibitors prepared and tested by JT researchers

AstraZeneca scientists present new P2X7 receptor antagonists in a recent patent

New cannabinoid CB2 receptor ligands in early development at Schering-Plough

New PDE5 inhibitors in Schering-Plough development pipeline

Compounds able to inhibit HDM2 or MDM2 binding to p53 and their use as antitumor agents

Inverse agonism of the CB1 receptor increases energy expenditure

Serotonin 5-HT6 receptor antagonism attenuates food intake and body weight

HMR-1426: a potent orally active anoretic

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