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BioWorld Science

Oct. 27, 2003

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Vical enters CRADA for West Nile virus vaccine development

Crucell malaria vaccine candidate to be evaluated in two collaborative programs

Ranbaxy and GSK enter drug discovery and development collaboration

Two series of alpha7 nAChR agonists prepared and tested at Bayer

New synthetic pateamine A analogues and their use as immunosuppressant agents

Novel HIV protease inhibitors developed by U. of Illinois researchers

Ariad describes bone antiresorptive proteasome inhibitors and their use

Quinoline-based PDE4 inhibitors and their use covered by Merck Frosst patent

New mGluR5 antagonists identified by Merck researchers

Merck claims new androgen receptor modulators for osteoporosis and other disorders

Positive results reported for ABR-215757 in a murine model of systemic lupus erythematosus

SB-431542, a potent inhibitor of TGF-beta signaling

New COX-2 inhibitor from Almirall effective in animal models of arthritis

BIRB-796, a p38 MAP kinase inhibitor, blocks both kinase activation and kinase activity

The synthetic chalcone AGI-2048 shows promise as an oral DMARD for RA

Met-RANTES, a CC chemokine receptor antagonist, shows activity in rat arthritis model

Alpha-lipoic acid found to suppress joint inflammation and destruction in murine arthritis

mTOR inhibitor RAD-001 in antibody-mediated autoimmunity

Top-line results from third phase III study of Entereg for postoperative ileus

Positive opinion handed down by CPMP for Advate

CETi-1 produces increase in HDL cholesterol in phase II trial

Dyax and URRMA enter alliance to develop anti-R7V antibodies for HIV

Avandamet approved in E.U.

Starlix approved in combination with TZD for type 2 diabetes

Yondelis receives E.U. orphan drug status for ovarian cancer

Roche and Nippon Shinyaku to develop drugs for dyslipidemia

Remicade approved in E.U. for maintenance dosing in fistulizing Crohn's disease

Preclinical studies support further development of MB-7133 for HCC

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