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BioWorld Science

Nov. 18, 2003

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Medtronic initiates Talent(TM) Thoracic Stent Graft Study in the US

Caspase-3 inhibition preserves myocardial geometry and long-term function postinfarction in mice

Neramexane shows promise for the treatment of alcohol dependence

Antalarmin reduces volitional ethanol consumption in rats

Hyperforin, an antidepressant with a novel mechanism of action

Pharmacological profiles of novel dual D2/5-HT1A-acting antipsychotics

Antidepressant/anxiolytic effects of CP-154526 shown in a rat model of depression

Proton pump inhibitors and cytochrome P-450 polymorphism in GERD

Therapeutic benefits of rabeprazole in ulcers and GERD

BIA-2-024 and BIA-2-093 reported less neurotoxic than current antiepileptics

Fast and potent analgesic effects of AZD-3582 in a rat model of monoarthritis

First evidence of antiinflammatory effects induced by cilomilast in COPD patients

New thyroid receptor antagonists and their use described in Karo Bio patent

Solvay scientists describe novel NK1 antagonists for pain, emesis, arthritis, etc.

Novartis claims MMP inhibitors with utility in neuropathic pain therapy

Gruenenthal patent covers new NBTI analogues with potential as analgesic agents

New NR2B NMDA antagonists in early development at Merck

Novel factor Xa inhibitors prepared and tested at Merck KGaA

New M3 antagonists/PDE4 inhibitors for COPD and other uses claimed by UCB team

Pliva presents azulene-based inhibitors of TNF-alpha and/or IL-1 production

Two phase III studies for Retaane planned for January

BTG seeks development partners for PDE-4 inhibitor portfolio

Encouraging results for Crucell's experimental malaria vaccine

Dendreon grants Kirin HLA-DR antibody license, regains Asian Provenge rights

Swiss prenotification of intent to approve Erbitux

Nobex to reacquire modified insulin molecule rights from GlaxoSmithKline

Arthron compounds produce sustained suppression of rheumatoid arthitis

Sinovac new name for Net Force Systems

Subcutaneous CERA increases plasma hemoglobin in patients with chronic renal anemia

Good safety profile found for pyridoxamine in patients with diabetic nephropathy

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