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BioWorld Science

Nov. 26, 2003

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Celltech reorganizes R&D operations

ICAgen and Abbott renew drug discovery collaboration

Twelve-month SOHO results reported

Plexxikon and Phenomix to develop novel drugs for oncology and inflammation

Increased antitumor activity with new formulations of Panzem

PPI-2458 inhibits primary tumor growth in mouse model of melanoma

NSC-703786 induces single-strand breaks and DNA-protein crosslinks in breast cancer cells

Herstatin stimulates apoptosis in human small cell lung carcinoma cells

Mechanism of action of the Hsp90 inhibitor CCT-018159 discussed in Boston

Four related series of Akt kinase inhibitors presented by Merck

New calpain inhibitors, their preparation and use, reported by Senju team

Eisai describes new agents with sigma receptor affinity and AChE-inhibitory activity

Novel analgesic kappa opioid agonists covered by Santen patent

Novel chemokine CCR3 antagonists prepared and tested at Teijin

New phenanthrene-based antibacterial agents identified by Japanese researchers

AnorMED initiates new phase II trial for AMD-3100

FDA lifts partial clinical hold on phase III trials of Oncophage

European CPMP hands down positive opinion for Faslodex

Climara Pro receives FDA approval

Urethane derivative of pladienolide B with enhanced antitumor activity

Monarsen receives orphan drug status for myasthenia gravis

Cholestagel recommended for approval in E.U.

ImClone seeks approval for Erbitux in Canada

Bucindolol outlicensed to ARCA Discovery

Applied Molecular Evolution to become Lilly subsidiary

NGV1, a VR1 antagonist with analgesic effects in inflammatory pain

Medarex given go-ahead to begin phase I/II trial of MDX-214

European CPMP issues positive opinion for oxybutynin transdermal patch

New analgesic CB2-selective cannabinoids characterized by Pharmos

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