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BioWorld Science

June 11, 2004

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Genmab highlights first quarter progress

Xenova make considerable progress during first quarter

GenVec focuses on progressing TNFerade into later stage clinical trials

Montelukast sodium may improve sleep disordered breathing in children

Update on the pharmacokinetics and effects of ciclesonide in asthma

Clinical response achieved with clofarabine in pediatric acute leukemia

Perifosine reported well tolerated in advanced cancer patients

Novel protein-tyrosine-phosphatase 1B inhibitor improves glucose homeostasis in vivo

Novel PPARgamma activator ameliorates insulin resistance via elevated adiponectin levels

Pharmacokinetics of new polyenemacrolide antifungal agent in rats

Novel DPP-IV inhibitor improves glucose tolerance but does not affect diabetes progression

Paired biopsy study shows normal bone formation after five years of risedronate

Orphan drug designation for Thymosin beta4 for epidermolysis bullosa

Canadian approval of Aldurazyme for MPS I

Proof-of-concept study begins for HCV-086

Phase II alfimeprase study in venous catheter occlusion completes interim analysis

Sativex produces positive results in phase II rheumatoid arthritis study

Isis to acquire Elan's interest in Orasense and HepaSense joint ventures

Promising phase II results for MDX-060 in Hodgkin's disease

Orphan drug status for MDX-101

Positive results for ATL-1102 for multiple sclerosis

Adenovirus vector VRX-011 has enhanced specific oncolytic efficacy and restriction in primary cells

Liraglutide reduces body weight in preclinical and clinical studies

Axokine benefits overweight, diabetic patients

GSK team describes new prostanoid EP1 modulators for pain and other disorders

New antibacterial and antifungal agents identified at GeneSoft

Novel Raf kinase inhibitors in early development at Merck KGaA

Merck Frosst describes a novel series of NO-releasing COX-2 inhibitors

Pfizer claims new ziprasidone derivatives and their use as antipsychotics

Triazole-based vasopressin V1a antagonists and their use in dysmenorrhea therapy

New nuclear hormone receptor ligands covered by Karo Bio patent

New glucocorticosteroids prepared and tested at GSK