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BioWorld Science

Sep. 23, 2010

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TCF4 gene variation implicated in Fuchs' corneal dystrophy

First selective Aurora kinase A inhibitors identified

Fixed-dose fenofibrate/pravastatin plus ezetimibe reduces hyperlipidemia in type 2 diabetes

High loading dose of clopidogrel may overcome effects of CYP2C19 genetic variant in persons with CAD

Multiple dosing of AMG-853 well tolerated in healthy volunteers

Kowa discloses new angiotensin antagonists/PPARgamma ligands

New inhibitors of IgE Fc receptor described by Fujitsu

Favorable safety and pharmacokinetics seen in phase I trials of anti-CMV agent AIC-246

New vancomycin carbamate derivative shows potent antibacterial activity in drug-resistant strains

FDA grants orphan drug status for DasKloster-0210

Micromet begins phase II trial of its BiTE antibody blinatumomab in ALL

FDA provides guidance to Apricus on phase III study RayVa trial

Global Health Ventures begins developing sublingual telcagepant for migraine

Topica announces sublicensing agreement for luliconazole for tinea infections

PTC receives FDA grant for phase III cystic fibrosis trial

Celldex begins phase IIb trial of CDX-011 in breast cancer

Relypsa completes financing round to support RLY-5016 development

Phase III TAMARIS trial in critical limb ischemia fails to meet primary endpoint

Cytokinetics and Amgen plan phase IIb trial of omecamtiv mecarbil in HF

Phase II trial of AERAS-402 TB vaccine candidate initiated in Kenya

FDA grants Novartis approval for Gilenya for the treatment of relapsing MS

Santhera to file MAA for use of Catena in Leber's hereditary optic neuropathy

Vermillion receives CE mark for OVA1 test for ovarian cancer detection

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