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BioWorld Science

Nov. 20, 2018

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Identification and preclinical characterization of ABX-1431, inhibitor of monoacylglycerol lipase

New type of neuronal insulation discovered

Sleeper HIV can be napping or conked out

NOXA gives leg up to BCL-2 inhibition

Immunocore and Genentech enter partnership to codevelop IMC-C103C

NLRP3 antagonist IFM-514 shows promise in mouse models of NASH

SNACing on peptides: findings may allow oral delivery of peptides

Nash Pharmaceuticals reports data on NP-135 in mouse model of kidney fibrosis

Aurigene's small molecule antagonist targets both PD-L1 and TIGIT pathways

Rocket Pharmaceuticals announces FDA clearance of IND for RP-L201 gene therapy

First patients dosed in phase I OPTIC study of ADVM-022 gene therapy in wet AMD

First-in-human results presented for NGM-313 in insulin-resistant obese patients with fatty liver

Samumed doses first subject in phase II/III study of SM-04554

First patient dosed in first-in-human study of NJA-730

French approvals to begin phase II trial of Tedopi and Opdivo in pancreatic cancer

Lunan Pharmaceutical Group presents IDO1 inhibitors

Denali reports promising phase I outcomes with RIPK1 inhibitor DNL-747

New DAT inhibitors may improve effort-related motivation dysfunction

Sentinel Oncology divulges PLK1 inhibitors

Interim phase I results show VLA-1601 induces neutralizing antibodies against Zika virus

Phase III trial of STAGR-320 in house dust mite-induced allergic rhinitis meets primary endpoint

Aviara Pharmaceuticals discloses ITGA4 and LPAM-1 antagonists

Machavert to use grant award to support RAL GTPase inhibitor development

Phase I data on BLU-5937 support progression to phase II for chronic cough

Ohara Pharmaceutical identifies anticancer agents

NIH grant supports IBBR's development of antibody therapeutic against HIV-1

Lupin identifies hSTING agonists for cancer and infections

GeoVax collaborates with Leidos on immunotherapy research program

CPI-818 demonstrates promising safety and efficacy in dogs with T-cell lymphoma

AZD-3229 demonstrates efficacy in preclinical models driven by KIT gene mutations

RSK3 inhibition by gene therapy reduces cardiac dysfunction after myocardial infarction in mice

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