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BioWorld Science

Feb. 7, 2019

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Same compound inhibits wild-type, activates mutant MALT1

Membrane rips kill axons in MS

Transcriptional CDK inhibitors downregulate brachyury in chordoma

PVRIG and TIGIT regulate CD8+ T cells/tumor cells interaction and can be a target for immunotherapy

REST-regulated gene secretagogin as a novel prognostic biomarker in prostate cancer

New cyclopeptides containing N-methyl amino acids with activity against several P. falciparum stages

Denali enzyme therapy for MPS II crosses the blood-brain barrier

University of Texas System divulges ATR kinase inhibitors

MEK/ERK2 pathway regulates Shank3 stability: a novel target for SHANK3-related disorders

ArmaGen arylsulfatase A fusion protein shows promise for metachromatic leukodystrophy

Misplaced energy turns T cells proinflammatory

Positive results announced from phase I study of LY-3056480 in sensorineural hearing loss

Updated clinical data presented from ongoing studies of AVR-RD-01 gene therapy for Fabry disease

Early cardiac hypertrophy seen in murine model of Pompe disease

FDA approves Cablivi for treatment of aTTP

Inhibrx begins first-in-human study of INBRX-105 bispecific antibody for cancer

U.S. researchers present new compounds for tuberculosis

ProtNeteomix identifies new EGFR degradation inducers

Evotec and Galapagos collaborate on small-molecule fibrotic disease program

Sichuan Haisco Pharmaceutical describes kappa-opioid receptor agonists

ReViral presents RSV fusion inhibitors as new antivirals

Axsome reaches SPA agreement with FDA on phase III trial for AXS-07 for acute migraine

Arch Oncology initiates phase I trial of AO-176 in select solid tumors

Roche conducts phase I trial of RO-7239958 for chronic HBV infection

Solid seeks to escalate dose in IGNITE DMD trial of SGT-001 following preliminary findings

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