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BioWorld Science

June 19, 2019

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Non-oncogene addiction to sirtuin in DLBCL

Favipiravir shows efficacy against Bourbon virus

Modification improves infliximab safety and response in RA

FDA accepts IND application for TAK-169

High rates of response seen with repotrectinib in fusion-positive NSCLC

Triumvira Immunologics cleared in U.S and Canada to conduct TAC01-CD19 studies

Dosing starts in phase I study of gene therapy to treat Danon disease

Vanflyta approved in Japan for the treatment of relapsed/refractory FLT3-ITD AML

Lenvatinib demonstrates promising antitumor activity and safety in phase II LEMON study in mCRC

Phase II results for lanreotide autogel 120 in inoperable malignant intestinal obstruction

Encouraging response rates seen for nanatinostat plus valganciclovir in EBV-associated lymphomas

Potential T2DM treatment HD-6277 well tolerated in first-in-human trial

Thioredoxin 1 fusion protein compositions described by Hallym University

Jounce initiates phase II trial of vopratelimab with ipilimumab in NSCLC or urothelial cancer

Suzhou Institute of Tongji University patents c-Met agonistic antibodies

FUD peptide targeting fibronectin patented by Wisconsin Alumni Research Foundation

Nanjing TransThera Biosciences identifies semicarbazide-sensitive amine oxidase inhibitors

Roche discovers monoglyceride lipase inhibitors

IQSEC1 gene mutations tied to intellectual disability and developmental delay

Miransertib studied in patients with PIK3CA-related overgrowth spectrum and Proteus syndrome

FDA approves Keytruda for metastatic SCLC after platinum and other prior therapy

Intuniv approved in Japan for adults with ADHD

Bevespi Aerosphere wins approval in Japan for COPD

Japan first to approve Breztri Aerosphere for COPD

Antitumor activity seen for acalabrutinib + pembrolizumab combination in relapsed/refractory DLBCL

CyTuVax reports results from phase II trial of HBAI-20 vaccine in hepatitis B nonresponders

Ultomiris approved in Japan for PNH

Therapix reports phase IIa interim data on THX-110 in patients with obstructive sleep apnea

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