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BioWorld Science

Nov. 26, 2019

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De novo loss-of-function mutations in FOXJ1 cause a motile ciliopathy characterized by hydrocephalus

AQP9 expression correlates with clear cell RCC progression and may have prognostic value

Analysis of genetic risk locus associated with abdominal aortic calcification identifies HDAC9

Malaria discovery may lead to better HIV and lupus treatments

Binging brains give themselves away

In cancer cells, beware the vicious circle

HLX-07 displays antitumor activity in patients with advanced solid tumors

New G12C mutant GTPase KRAS inhibitors identified at AstraZeneca

APRINOIA Therapeutics describes compounds targeting microtubule-associated protein tau

Shanghai Institute of Materia Medica patents farnesoid X receptor agonists

UCB discovers synaptic vesicle glycoprotein 2A/2C ligands

Aziende Chimiche Riunite Angelini Francesco presents GSK-3beta inhibitors

Antifilarial therapy against onchocerciasis presented

TFF Pharmaceuticals initiates phase I study of voriconazole inhalation powder

Agenus studies anti-CD137 antibody AGEN-2373 in phase I for advanced cancer

ORCA Therapeutics initiates first-in-human study of ORCA-010 in prostate cancer

Clinical activity seen with sitravatinib and nivolumab in refractory urothelial carcinoma

Adamis Pharmaceuticals receives a complete response letter regarding Zimhi

CymaBay stops clinical development of seladelpar

Takeda Vaccines presents data on TAK-426 for Zika virus

Phase III ADVOCATE trial of avacopan in ANCA vasculitis meets primary endpoints

EpicentRx reports phase I data on RRx-001 in newly diagnosed glioblastoma

ACADIA reports phase II topline results on pimavanserin for negative symptoms of schizophrenia

Poxel reports topline data from TIMES 3 open-label extension of imeglimin in type 2 diabetes

Enrollment underway in ImmunoGen's phase I/II study of IMGN-632 in AML

FDA grants accelerated approval to Oxbryta for sickle cell disease

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