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BioWorld Science

June 10, 2020

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C12orf49 is new lipid metabolism gene

Simultaneous dual base editing

Dual JAK1/TYK2 inhibitor TLL-018 shows dose-dependent anti-inflammatory activity in arthritis models

Phase I data presented for URAT1 inhibitor D-0120

FDA clears IND application for PTX-35

BeyondSpring presents positive data from PROTECTIVE-2 study of plinabulin plus Neulasta

First patient dosed in phase Ib study of RMC-4630 in combination with AMG-510

First-in-human data for MGD-013 in unresectable or metastatic neoplasms

HX-008 plus irinotecan show promising activity in advanced gastric adenocarcinoma

TV technology wants to be brain delivery's all-terrain vehicle

Loss-of-function mutations in JAM2 gene cause familial brain calcification

Phase I study finds manageable toxicity with LY-2880070 alone and with gemcitabine

Black Belt TX patents arginase inhibitors

Taisho Pharmaceutical discloses new antibacterials

Grey Wolf Therapeutics synthesizes ERAP1 inhibitors

Merck & Co. describes new adenosine A2A and/or A2B receptor antagonists

Opthea reports phase IIa topline data on OPT-302 for refractory DME

Bacainn announces phase I study initiation for ulcerative colitis candidate BT-051

NLRP3 inhibitors presented by Novartis Inflammasome Research

Wharton's jelly-derived mesenchymal stem cells effective in graft-versus-host disease trial

FDA allows phase III protocol for SPI-1005 for Meniere's disease

Fulcrum submits IND for phase III study of losmapimod for COVID-19

Pfizer reports topline data from JADE TEEN trial of abrocitinib in adolescent atopic dermatitis

NFlection initiates phase IIa study of NFX-179 gel for cutaneous NF-1

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