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BioWorld Science

March 31, 2021

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Wave ends clinical development of WVE-120102 and WVE-120101 for Huntington's disease

New model of MECP2 duplication syndrome may advance antisense oligonucleotide treatment

Dosing begins in phase I study of DD-01 in obese patients with diabetes and NAFLD

Pediatric study of CRV-101 against varicella in HIV-positive children approved in South Africa

FDA approves IND application for phase I study of TJ-CD4B bispecific antibody

Promising data from first 4 patients treated with BS-01 optogenetic gene therapy

INSERM and others present monoclonal antibodies targeting IL-20RB

TaiGen Biotechnology discovers hepatitis B antiviral agents

Yhhu-2407, novel low systemic DGAT1 inhibitor with potential for the treatment of dyslipidemia

New agents for encephalitic alphaviruses identified at the Wisconsin Alumni Research Foundation

The University of Texas System divulges RIP-1 inhibitors

177Lu-DOTA-EB-TATE is well tolerated and effective in patients with late-stage NETs

New genetic variants in CD80 found to have prognostic value in prostate cancer

New SHP-2 inhibitors identified at Sichuan Kelun-Biotech Biopharmaceutical

Equillium reports data from ongoing phase Ib study of itolizumab in SLE

China NMPA clears CTA for basket trial of Trodelvy for cancers with high TROP-2 expression

FDA approves Vyxeos for secondary AML in pediatric patients

Huyabio signs clinical collaboration agreement for phase III melanoma trial of HBI-8000 with Opdivo

Squalenoyl siRNA PMP22 nanoparticles developed for Charcot-Marie-Tooth disease type 1 A

FDA clears initiation of first-in-human study of CRISPR_SCD-001 for sickle cell disease

Cabometyx with Opdivo approved in E.U. for first-line advanced RCC

European Commission approves Ontozry for drug-resistant focal-onset seizures in adults

Disulfiram blocks conformational changes of the complex between human p97 and its cofactor Npl4/Ufd1

Kamada reports phase I/II topline results on anti-SARS-CoV-2 plasma-derived IgG

Pivotal topline data on BNT-162b2 in adolescents aged 12-15 years

ChromaDex announces research initiative to study effects of Niagen and citrin deficiency

FDA clears IND for phase I/IIa study of AFM-24 with SNK-01 for EGFR-expressing solid tumors

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