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BioWorld Science

April 30, 2021

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Boehringer Ingelheim initiates phase I study of BI-1701963 alone or in combination with BI-3011441

ERX-963 does not improve sleepiness in myotonic dystrophy type 1 patients

Enrollment opens in phase II/III study of MK-5475 in PAH

Enrollment opens in first-in-human study of OMO-103 in solid tumors

Cereno and University of Michigan collaborate on preclinical development of CS-585

Analysis of immunological and inflammatory factors associated with COVID-19 severity and progression

Xencor initiates phase I study of XmAb-564 for autoimmune diseases

X chromosome reactivation widely affects proteome

New STING receptor antagonists identified at IFM Due

Molecular Skin Therapeutics describes dual kallikrein 5/7 inhibitors

PD-1/PD-L1 interaction inhibitors identified at Bristol Myers Squibb

Recurium IP Holdings patents ERK-1 and/or ERK-2 inhibitors

Goldfinch Biopharma discovers CDK5 inhibitors

First clinical trial evaluating intravesical bacteriophage therapy for the treatment of UTIs

Atogepant statistically reduces monthly migraine days in phase III trial

First-in-class KAT6A/KAT6B inhibitor PF-9363 shows antitumor activity against ER+ breast cancer

Phase III NEPTUNO study of plitidepsin in COVID-19 receives authorization in Spain

PRT-1419 shows potent antitumor activity in preclinical models

MiR-17-92 as a therapeutic target in lupus nephritis and other autoimmune diseases

Neuromelanin MRI predicts treatment response in patients with first-episode schizophrenia

miR-206 is a prognostic marker of LGMDD2 disease progression

Phase II trial of vonoprazan regimens for H. pylori infection meets endpoints

Phase IIb/III study of masitinib in metastatic CRPC meets primary endpoint

Phase II trial evaluates ImmunityBio Anktiva with ART to inhibit HIV reservoirs

Mesoblast reports 60-day results on remestemcel-L in COVID-19 related ARDS

Preclinical through phase III, new COVID-19 therapy trials ramp up

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