Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia, have developed a new genome editing technique than can activate any gene, including those that have been silenced, allowing new drug targets and causes of drug resistance to be explored. Read More
A Mayo Clinic study demonstrated how the deficiency of the enzyme CDK12 or its regulation by cyclin K causes the expression of mutations related to resistance to endocrine therapy in prostate cancer. Prostate tumors with CDK12 deficiency are more aggressive, recurrent, produce metastases and are associated with castration-resistant prostate cancer (CRPC). CDK12 deficiency impairs DNA repair and increases genomic instability, causing an effect known as homologous recombination deficiency or BRCAness. Read More
Researchers from Chongqing Medical University have discovered novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors for the treatment of ALK-positive cancer. Read More
A Surrozen Inc. research team has reported preclinical data for the novel frizzled class receptor 4 (FZD4) agonist, SZN-413, being evaluated for the treatment of diabetic retinopathy. In vitro studies using the Norrin mimetic (SZN-413-p) revealed that SZN-413-p induced Wnt/β-catenin signaling and upregulated blood-brain barrier/blood-retina barrier gene expressions in endothelial cells. Read More
Kupando GmbH has closed a series A funding round raising €13 million. The funds will be used to complete IND-enabling work and to initiate the clinical development of Kupando's lead candidate KUP-101 in a solid tumor indication. Read More
Researchers from University College Dublin and affiliated organizations presented data from a study that aimed to assess the role of α-melanocyte-stimulatory hormone (α-MSH) in diabetes. Read More
Cleara Biotech BV has closed a $2.5 million seed financing round, the proceeds of which will be used to progress its compounds toward clinical development and build the company's developmental pipeline. Read More
Moleculin Biotech Inc.'s WP-1096 molecule is set to be evaluated in animal studies through the preclinical services offered by the National Institute of Allergy and Infectious Diseases (NIAID). Read More
Ambulero Inc., a spinout from the University of Miami Miller School of Medicine, has received a positive response from a type B pre-IND meeting with the FDA on the development of AMB-301 as a treatment for the vascular disease Buerger's disease. Read More
Hillstream Biopharma Inc. has described new salinomycin derivatives acting as angiogenesis inhibitors reported to be useful for the treatment of cancer. Read More
The State University of New York has presented new antibody-drug conjugates (ADCs) consisting of trastuzumab antibody targeting human epidermal growth factor receptor 2 (HER2) covalently linked to Toll-like receptor 7 (TLR7) and/or TLR8 agonists through a linker reported to be useful for the treatment of cancer and infections. Read More
The University of Michigan has synthesized new proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked estrogen receptor (ER) targeting moiety reported to be useful for the treatment of breast cancer. Read More
Eli Lilly & Co. has identified new fibroblast growth factor receptor 3 (FGFR3) inhibitors reported to be useful for the treatment of achondroplasia, cancer, pulmonary fibrosis, systemic scleroderma and thanatophoric dysplasia, among other disorders. Read More
