Both neutralizing antibodies and antibody effector functions are needed for protection against re-infection with respiratory syncytial virus (RSV), which may explain why it has been challenging to design an effective vaccine against the virus. As reported in the Dec. 12, 2022, issue of Cell, researchers carried out a human challenge study where volunteers were given a candidate vaccine for RSV, Ad26, or placebo. Read More
A combination of bioengineering techniques on normal cell binding proteins could be the method of the future for selective cell binding. Scientists at the University of California, San Francisco (UCSF) have created a synthetic glue based on the expression of membrane receptors to establish the desired connection between cells. The results may be applied in different fields of cell biology or biomedicine, such as regeneration and wound repair, including the nervous system, or cancer. Read More
Janssen Pharmaceutica NV reported on the company’s novel fully human immunoglobulin G1 CD79bxCD20xCD3 trispecific antibody JNJ-80948543, comprising an anti-CD3 ε single-chain variable fragment (scFv), an anti-CD20 scFv, and an anti-CD79b fragment antigen-binding (Fab) domain and an effector-silent Fc, designed to redirect T cells to treat patients whose disease no longer responds to previous lines of therapy. Read More
Preliminary preclinical data have been reported for Enliven Therapeutics Inc.’s ATP-competitive small-molecule ABL1 tyrosine kinase inhibitor (TKI) ELVN-001. In vitro antiproliferative effects, assessed using the biomarker Tyr207-phosphorylated CRKL, demonstrated that ELVN-001 had potent activity with IC50 values ranging from 19 to 112 nM against BCR-ABL1-driven chronic myeloid leukemia (CML) cell lines in the presence of 50% to 100% human serum. Read More
Novelmed Therapeutics Inc. has reported topline results with its lead anti-properdin antibody NM-3086 in a rabbit model of paroxysmal nocturnal hemoglobinuria (PNH). NM-3086 is a potent, first-in-class, humanized monoclonal antibody that is highly selective for properdin of the alternative pathway (AP) without blocking the classical pathway (CP), which is critical for maintaining host defense against infections. Read More
Onchilles Pharma Inc. has nominated its first drug development candidate, N-17350, a first-in-class biologic therapeutic that is designed to leverage the immunobiology of neutrophils against a wide range of cancer types. Research published last year first described a pathway where human neutrophils release catalytically active neutrophil elastase, called ELANE, to selectively kill many cancer cell types while sparing noncancer cells. Read More
Spexis AG has released results from an in vitro study evaluating the effects of combining its potent CXCR4 inhibitor balixafortide (BLX) with several available conventional or targeted therapies in B-cell lymphoma models. Read More
Farnesoid X receptor (FXR) has been previously identified as an important drug target for nonalcoholic steatohepatitis (NASH) and other related diseases, with GW-4064 being the first nonsteroidal FXR agonist used to explore the biological functions of FXR. Scientists at KBP Biosciences Co. Ltd. and Shandong University designed a novel series of FXR agonists as potential candidates for the treatment of NASH. Read More
Vertex Pharmaceuticals Inc. has received clearance from the FDA for its IND application for VX-522, a messenger ribonucleic acid (mRNA) therapy targeted at treating the underlying cause of cystic fibrosis (CF). Read More
Carina Biotech Pty Ltd. has submitted an IND application to the FDA to conduct a first-in-human phase I/IIa trial of CNA-3103, its LGR5-targeted chimeric antigen receptor T-cell (CAR-T) therapy candidate, in patients with advanced colorectal cancer. Read More
Severe toxicities associated with immune checkpoint inhibitor (ICI) therapy are a major challenge of this anticancer therapy approach. While myocarditis is a rare immune-related adverse event in patients receiving ICIs, it has a nearly 50% mortality rate and its pathogenesis is poorly understood. In the current study, researchers from Vanderbilt University and affiliated organizations published data from a study that evaluated a novel mouse model recapitulating clinical and pathological features of ICI-associated myocarditis (ICI-MC). Read More
The National Center for Global Health and Medicine (NCGM) and Tokyo Medical and Dental University have divulged 3C-like protease (3CLpro) (SARS-CoV-2) inhibitors reported to be useful for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections (COVID-19). Read More
Dana-Farber Cancer Institute Inc. and Cornell University have disclosed phosphatidylinositol 5-phosphate 4-kinase type-2 γ (PIP4K2C) inhibitors and its PROTAC compounds reported to be useful for the treatment of cancer, infections, immunodeficiency disorders, insulin resistance, autoimmune and Huntington's disease. Read More
1st Biotherapeutics Inc. has received clearance from the FDA for its IND application to evaluate FB-849, a small-molecule hematopoietic progenitor kinase 1 (HPK1) inhibitor, in patients with advanced solid tumors. Read More
Sironax Ltd. has disclosed receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors reported to be useful for the treatment of ulcerative colitis, Crohn's disease, psoriasis, rheumatoid arthritis, amyotrophic lateral sclerosis (ALS), Alzheimer's disease and viral infection. Read More
Starton Therapeutics Inc. has reported findings from a preclinical efficacy study of STAR-LLD, a continuous delivery system of lenalidomide, in a lenalidomide-resistant animal model. The 28-day efficacy study evaluated STAR-LLD continuous subcutaneous (s.c.) infusion versus intraperitoneal (i.p.) lenalidomide in immunomodulatory drug (IMiD)-resistant RPMI CB.17 SCID mice. Read More
CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co. Ltd. has patented spiro compounds acting as tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) inhibitors reported to be useful for the treatment of cancer and cardiovascular and immunological disorders. Read More
New and updated preclinical data presented at the American Society of Hematology Annual Meeting in New Orleans, by: Ajax Therapeutics, Biomea Fusion, Cimeio Therapeutics, Fate Therapeutics, Graphite Bio, GT Biopharma, Ichnos Sciences, IGM Biosciences, Incyte, Kronos Bio, Kymera Therapeutics, Monopar Therapeutics, Orum Therapeutics, OSE Immunotherapeutics, Poseida Therapeutics, Puretech Health, Schrödinger, Senti Biosciences, Vincerx Pharma, Wugen. Read More
