A study from the University Medical Center Hamburg-Eppendorf (UKE) in Germany has identified a type of T cell that triggered glomerulonephritis (GN) and produced loss of kidney function in mice. The scientists described an autoimmune pathway of this disease mediated by the accumulation of T cells producing granulocyte-macrophage colony-stimulating factor (GM-CSF) in the kidneys and found a possible therapeutic target. Read More

Body mass index (BMI), which is calculated from height and weight, and its relationship to health is a hotly debated area of health. On the one hand, “it’s cheap, it’s intuitive, it’s noninvasive and easy to calculate,” Noa Rappaport told BioWorld. “But it misses a lot.” In the March 20, 2023, online issue of Nature Medicine, Rappaport’s group describes an alternative measure, which they have termed the biological BMI, that “better reflects metabolic health than traditional BMI,” said Rappaport, who is a senior research scientist at the Institute for Systems Biology and the paper’s corresponding author. Read More

Rayzebio Inc. has nominated a first-in-class novel peptide drug candidate against glypican-3... Read More

Ocean Biomedical Inc. has outlined details of its novel approach to treating malaria. Building on... Read More

Researchers from Central South University presented the discovery of novel FAK inhibitors... Read More

Stimulator of interferon genes protein (STING), an intracellular adaptor molecule that can detect... Read More

Shanghai Leadingtac Pharmaceutical Co. Ltd. has disclosed proteolysis targeting chimeras... Read More

Galixir Inc. has synthesized aromatic heterocyclic compounds acting as tyrosine-protein kinase... Read More

Geleophysic dysplasia (GD) is an autosomal recessive disease characterized by facial features, short stature, limited joint mobility and cardiovascular and respiratory abnormalities, which can lead to a significant mortality rate. The disease is caused by biallelic genetic variants in the ADAMTSL2 gene. Little is known about the pathogenesis of the disease, but dysregulation of the TGF-β pathway has been shown to be involved. Read More

Genome sequencing is a successful approach for simultaneously detecting both copy number variants and sequence variants in genes involved in autosomal recessive diseases. Read More

Accellena Research and Development LLC has identified substituted 2-(5-aryl-4H-1,2,4-triazol-3-yl)ethanamines acting as trace amine-associated receptor 1 (TAAR1; TAR1) agonists reported to be useful for the treatment of cardiovascular disorders, diabetes, metabolic diseases, migraine, neurological disorders, obesity, psychiatric disorders and substance abuse and dependence. Read More

Researchers from Baylor College of Medicine presented data from postnatal testing with the aim of providing molecular diagnosis for a patient with prenatally diagnosed heterotaxy syndrome. Read More

Phenylketonuria (PKU) is an autosomal recessive disorder where the primary catabolic pathway for phenylalanine (Phe) is disrupted due to mutations in the gene encoding PAH. Elevated Phe levels lie behind several neuropathologic anomalies that can lead to severe and irreversible mental retardation, if untreated. Read More

Volastra Therapeutics Inc. has divulged kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer. Read More

The role that mitochondrial inner membrane protein (IMMT) has in regards to clinicopathology and tumor microenvironment in breast cancer in unclear. IMMT is part of the mitochondrial contact site and cristae organizing system (MICOS) and its function is to maintain mitochondrial integrity. Read More

Shanghai Visonpharma Co. Ltd. has described Toll-like receptor 7 (TLR7) and/or TLR8 antagonists reported to be useful for the treatment of multiple sclerosis, lupus nephritis, psoriasis, rheumatoid arthritis, systemic scleroderma (systemic sclerosis), Sjogren syndrome and systemic lupus erythematosus. Read More