The hyperactivation of the Wnt/β-catenin signaling pathway plays a central role in the progression and expansion of colorectal cancer (CRC). The suppression of this pathway may contribute to the control of the proliferation, survival and metastasis of CRC. Read More

Immunesensor Therapeutics Inc. has received Human Research Ethics Committee (HREC) approval and clinical trial notification (CTN) clearance by Australia’s Therapeutic Goods Administration (TGA) to initiate a phase I study of IMSB-301, a novel, orally available small-molecule cGAS inhibitor that is being developed for the treatment of inflammatory and autoimmune diseases. Read More

Tonix Pharmaceuticals Holding Corp. is advancing development of its live attenuated virus vaccine, TNX-801 (recombinant horsepox virus), for preventing mpox and other infectious diseases. Read More

Shanghai Institute of Materia Medica of the Chinese Academy of Sciences has disclosed phthalazinone or quinazolinone derivatives acting as poly(ADP-ribose) polymerase (PARP) inhibitors reported to be useful for the treatment of cancer. Read More

Pregnane X receptor (PXR) is a transcription factor that plays a crucial role in maintaining bile acid homeostasis by regulating major metabolizing enzymes and transporters. Read More

From no hope to viable treatments, BioWorld  is there to cover the breakthroughs in medicine. Listen to Randy Osborne explain why the BioWorld  team is ‘always on the lookout for what's next.’ Read More

Innovec Pharmaceutical Technology Co. Ltd. (Innovec Biotherapeutics) has received FDA clearance for its IND application for IVB-103, an AAV-based gene therapy for neovascular age-related macular degeneration (AMD). Read More

Gwangju Institute of Science & Technology has synthesized compounds reported to be useful for the treatment of atopic dermatitis and inflammatory bowel disease. Read More

Boehringer Ingelheim Pharma GmbH & Co KG has identified drug conjugates acting as neuromedin U receptor 2 (NMU2) agonists reported to be useful for the treatment of obesity. Read More

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion involved in controlling blood pressure and volume in the cardiovascular system. Antagonists of the angiotensin II type 1 (AT1) receptor are used for the management of hypertension with proven efficacy. Read More

Shenzhen Crystalo Biopharma Technology Co. Ltd. has divulged short transient receptor potential channel 5 (TRPC5) antagonists reported to be useful for the treatment of anxiety, depression, post-traumatic stress, diabetic nephropathy and focal segmental glomerulosclerosis. Read More

Researchers at F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have described GTPase KRAS mutant inhibitors, particularly KRAS G12C mutant, reported to be useful for the treatment of cancer. Read More

Recent findings suggest gut microbiota dysbiosis may be behind the inflammation in diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD). Read More