IMU Biosciences Ltd. is working to transform society’s understanding of the immune system. The company’s platform maps the immune system at molecular, cellular and system levels, to unlock new insights into immune-related health and diseases, paving the way for clinical applications that could improve patient outcomes. Read More
Barth syndrome is a rare genetic disorder caused by mutations in the TAZ gene, which encodes an enzyme essential for remodeling cardiolipin, critical for mitochondrial function. A recent study published in Nature identified the enzyme ABHD18 as a candidate deacylase in the cardiolipin biosynthesis pathway and a potential therapeutic target for this syndrome. Read More
Lila Biologics Inc. has entered into a global licensing and multitarget research collaboration with Eli Lilly & Co. focused on the discovery, development and commercialization of novel radioligand therapies for imaging and treatment of solid tumors. Read More
Small fiber neuropathy (SFN) is a chronic and debilitating condition caused by damage to peripheral sensory nerves, which are responsible for pain, temperature sensation and autonomic functions. Current treatments are limited, highlighting the need for better therapies. Read More
Otsuka Pharmaceutical Co. Ltd. has identified new piperidine- and morpholine-carboxylate compounds acting as sortilin (SORT; NT3; Gp95) antagonists. As such, they are described as potentially useful for the treatment of amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer’s and Parkinson’s disease. Read More
In a recent study published in Cell Reports, a team of scientists from Gilead Sciences Inc. and the University of Cincinnati detail the discovery and engineering of potent bispecific antibodies that can significantly reduce lesion development in a guinea pig model of recurrent genital herpes. Read More
Researchers from the Chinese Academy of Sciences have explored a novel approach using lipid nanoparticles (LNPs) to generate fibroblast activation protein (FAP)-targeted chimeric antigen receptor (CAR) macrophages in vivo and evaluated their potential to mitigate cardiac fibrosis and improve heart function after myocardial ischemia-reperfusion (I/R) injury. Read More
Several French institutions, including the University of Rennes, have prepared and tested disubstituted ferrocene complexes acting as viral replication inhibitors reported to be useful for the treatment of viral infections. Read More
A Juno Therapeutics Inc. patent describes pyrazole-based DNA-dependent protein kinase (DNA-PK) inhibitors reported to be useful for the treatment of cancer. Read More
For treating bipolar disorder, investigators have explored single strategies targeting dopamine receptors or the glycogen synthase kinase-3 (GSK-3) pathway. Researchers at Istituto Italiano di Tecnologia and collaborators have used computational modeling and structure determination to improve on a prototype small molecule capable of simultaneously activating the dopamine D3 receptor while inhibiting GSK-3β. Read More
Investigators at the University of Texas have synthesized new mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) and Bruton tyrosine kinase (BTK) dual-target inhibitors reported to be useful for the treatment of cancer, autoimmune and inflammatory disorders. Read More
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), an enzyme involved in one-carbon metabolism, is significantly overexpressed in cancer cells but shows limited expression in normal tissues, making it a promising target for cancer therapy. Read More
Additional early-stage research and drug discovery news in brief, from: Clene, Hoth Therapeutics, Skye Biosciences, Umecrine Cognition, Valitor. Read More
