Samaritan Pharmaceuticals Inc., of Las Vegas, named Jack L. Ayala and Robert W. Crane to its board of directors.

Sirtris Pharmaceuticals Inc., of Cambridge, Mass., appointed Jeffrey Capello to its board of directors.

T2 Biosystems Inc., of Cambridge, Mass., appointed John McDonough chief executive officer.

The Medicines Co., of Parsippany, N.J., named James Ferguson vice president of global medical, surgical and critical care.

Trellis Bioscience, of San Francisco, appointed John J. Wulf executive vice president of business operations and chief business officer.

ViroPharma Inc., of Exton, Pa., named Thomas F. Doyle vice president of strategic initiatives and appointed J. Peter Wolf vice president, general counsel and secretary of the board of directors.