Underwriter Biotechnology CompanyDate pricedOffering price per share**12/31/07 Share PriceOffering Gross (M)**After-Market Performance (%)

AG Edwards Securities
BioMimetic Therapeutics Inc.(BMTI) 2/9$17.15$17.37$43.2+1%
La Jolla Pharmaceutical Co. (LJPC) 3/30$6$3.92$40.12-35%
Molecular Insight Pharmaceuticals Inc. (MIPI) (IPO)2/2$14$9.06$70-35%
Allen & Co. LLCJavelin Pharmaceuticals Inc. (AMEX:JAV) 5/11$6$3.74$42.6-38%
Nanosphere Inc.(NSPH) (IPO)11/1$14$13.99$98-0.07%
Bank of America SecuritiesAcadia Pharmaceuticals Inc. (ACAD) (co-lead)4/5$15.50$11.07$102.3-29%
Acorda Therapeutics Inc. (ACOR) (co-lead)6/8$18.50$21.96$77.48+19%
Allos Therapeutics Inc. (ALTH) 1/30$6$6.29$54+5%
Array BioPharma Inc. (ARRY) (co-lead)5/2$13$8.42$91-35%
Biodel Inc.(BIOD) (co-lead; IPO)5/11$15$23.23$86.25+55%
Eurand International SpA (EURX) (IPO)5/17$16$15.80$112-1%
Genoptix Inc.(GXDX) (IPO)10/30$17$30.70$85.9-1%
Onyx Pharmaceuticals Inc. (ONXX) 6/21$28$55.62$185+99%
Pharmasset Inc. (VRUS) (co-lead; IPO)4/27$9$13.50$45+50%
Pharmion Corp. (PHRM) (co-lead)5/11$30 $62.86$138+110%
Vanda Pharmaceuticals Inc. (VNDA)1/19$27.29$6.88$120.1-75%
Bear, Stearns & Co.AMAG Pharmaceuticals Inc. (AMAG) (co-lead) (formerly Advanced Magnetics Inc.)5/23$65.14$55.18$60.13-8%
Bruker BioSciences Corp. (BRKR) (co-lead)2/13$7.10$8.09$13.30+87%
Cardiome Pharma Corp. (CRME) (co-lead)1/18$10.50$8.92$96.6-15%
Clinical Data Inc. (CLDA) (lead)7/24$22$22.25$75.9+1%
Synta Pharmaceuticals Corp. (SNTA) (co-lead; IPO)2/6$10$6.70$50-33%
Blackmont CapitalNovaBay Pharmaceuticals Inc. (AMEX:NBY) (IPO)10/26$4$3.76$20-6%
BMO Capital Markets Bionovo Inc.(BNVI) (co-lead)10/26$2.50$1.71$25-32%
EpiCept Corp. (EPCT) 10/10$1.88$1.27$8-32%
Broadpoint Capital Inc.Anesiva Inc.(ANSV) 12/26$4.05$5.00$49.8+23%
Canaccord AdamsBionovo Inc.(BNVI) (co-lead)10/26$2.50$1.71$25-32%
Cardiome Pharma Corp. (CRME)1/18$10.50$8.92$96.6-15%
Pharmacopeia Inc. (PCOP) 5/2$5$4.77$40-5%
Caris & Co.Response Genetics Inc.(RGDX) (IPO)6/5$7$4.65$21-34%
C.E. Unterberg, TowbinRosetta Genomics Ltd. (ROSG) (lead; IPO)2/27$7$5.14$30.2-27%
Sunesis Pharmaceuticals Inc. (SNSS) 5/24$4.43$1.99$21-55%
CIBC World Markets3SBIO Inc. (SSRX) (IPO)2/7$16$14.88$115.2-7%
Arena Pharmaceuticals Inc. (ARNA) (IPO; co-lead)11/2$9.91$7.83$109.01-21%
ArQule Inc. (ARQL) (co-lead)6/14$7.75$5.80$58.19-25%
ARYx Therapeutics Inc. (ARYX) (IPO)11/7$10$7.75$50-23%
Cardiome Pharma Corp. (CRME) (co-lead)1/18$10.50$8.92$96.6-15%
Cypress Bioscience Inc. (CYPB) (co-lead)5/30$15.50$11.03$72.9-29%
InterMune Inc. (ITMN)9/21$19.50$13.33$88.2-32%
Pharmacopeia Inc. (PCOP) (lead)5/2$5$4.77$40-5%
Poniard Pharmaceuticals Inc. (PARD) (co-lead)4/25$6.33$4.41$74.7-30%
CIBC World Markets
Progenics Pharmaceuticals Inc. (PGNX) 9/20$23.15$18.07$57-22%
Protalix Bio-Therapeutics Inc. (AMEX:PLX) 10/25$5$3.40$50-32%
Repros Therapeutics Inc. (RPRX) (co-lead)1/31$13.75$9.32$35.9-32%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO)5/23$10$13.69$69+37%
Sucampo Pharmaceuticals Inc. (SCMP)(IPO)8/3$11.50$18.34$35.94+59%
Cowen & Co.Altus Pharmaceuticals Inc. (ALTU) 4/19$14.75$5.18$88.5-65%
Genoptix Inc.(GXDX) (IPO)10/30$17$30.70$85.9+81%
Pharmion Corp.(PHRM) (co-lead)5/11$30$62.86$138+110%
Sucampo Pharmaceuticals Inc. (SCMP) (lead; IPO)8/3$11.50$18.34$35.94+59%
Sunesis Pharmaceuticals Inc. (SNSS) 5/24$4.43$1.99$21-55%
Targanta Therapeutics Corp. (TARG) (IPO)10/10$10$9.04$57.5-10%
Credit Suisse SecuritiesJazzPharmaceuticals Inc. (JAZZ) (IPO)6/1$18$14.70$108-18%
Nanosphere Inc. (NSPH) (IPO; lead)11/1$14$13.99$98-0.07%
Rigel Pharmaceuticals Inc. (RIGL) (co-lead)5/3$9.75$25.39$48.8+160%
Targanta Therapeutics Corp. (TARG) (IPO; lead)10/10$10$9.04$57.5-10%
Dawson James SecuritiesA.P. Pharma Inc. (APPA) 6/14$1.65$1.58$40.24-4%
Biopure Corp. (BPUR) (lead)11/1$0.85$0.64$16.5-25%
Neurobiological Technologies Inc. (NTII) 10/30$2.75$3.08$60+12%
NovaBay Pharmaceuticals Inc. (AMEX:NBY) (IPO)10/26$4$3.76$20-6%
Desjardins SecuritiesNovaBay Pharmaceuticals Inc. (AMEX:NBY) (IPO; co-lead)10/26$4$3.76$20-6%
Deutsche Bank SecuritiesAcadia Pharmaceuticals Inc. (ACAD) (co-lead)4/5$15.50$11.07$102.3-29%
Acorda Therapeutics Inc. (ACOR) (co-lead)6/8$18.50$21.96$77.48+19%
AMAG Pharmaceuticals Inc. (AMAG) (formerly Advanced Magnetics Inc.)5/23$65.14$60.13$162.9-8%
BioMimetic Therapeutics Inc. (BMTI) (co-lead)2/9$17.15$17.37$43.2+1%
Dyax Corp. (DYAX)7/13$3.67$3.66$44.4-0.3%
Eurand International SpA (EURX) (co-lead; IPO)5/17$16$15.80$112-1%
InterMune Inc. (ITMN) (co-lead)9/21$19.50$13.33$88.2-32%
MAP Pharmaceuticals Inc. (MAPP) (IPO)10/5$12$17.51$69+46%
Dundee SecuritiesNovaBay Pharmaceuticals Inc. (AMEX:NBY) (IPO; co-lead)10/26$4$3.76$20-6%
First Albany CapitalBioMimetic Therapeutics Inc. (BMTI) 2/9$17.15$17.37$43.2+1%
Fortis SecuritiesAcorda Therapeutics Inc. (ACOR)6/8$18.50$11.07$77.48-40%
Anesiva Inc. (ANSV) 12/26$4.05$5.00$49.8+23%
ArQule Inc. (ARQL) 6/14$7.75$5.80$58.19-25%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11$6$3.74$42.6-38%
Friedman, Billings, Ramsey Goldman, Sachs & Co.Pharmion Corp.(PHRM) 5/11$30$62.86$120+110%
Exelixis Inc. (EXEL) (lead)9/13$10.30$8.63$72.1-16%
InterMune Inc. (ITMN) (co-lead)9/21$19.50$13.33$88.2-32%
HSBC Securities (USA) Inc.Pharmion Corp.(PHRM) 5/11$30$62.86$120+110%
I-Bankers SecuritiesImaRx Therapeutics Inc. (IMRX) (IPO)7/25$5$1.93$15-61%
Jefferies & Co.AMAG Pharmaceuticals Inc.(AMAG) (formerly Advanced Magnetics Inc.)5/23$65.14$60.13$162.9-8%
Array BioPharma Inc. (ARRY) 5/2$13$8.42$91-35%
ARYx Therapeutics Inc. (ARYX) (IPO)11/7$10$7.75$50-23%
Cypress Bioscience Inc.(CYPB) (co-lead)5/30$15.50$11.03$72.9-29%
Molecular Insight Pharmaceuticals Inc. (MIPI) (co-lead; IPO)2/2$14$9.06$70-35%
Optimer Pharmaceuticals Inc. (OPTR) (co-lead; IPO)2/9$7$7.00$490%
JMP Securities LLCAcadia Pharmaceuticals Inc. (ACAD) 4/5$15.50$11.07$102.3-29%
Allos Therapeutics Inc. (ALTH) 1/30$6$6.29$54+5%
Genomic Health Inc. (GHDX) 5/22$15.50$22.64$46.5+46%
Optimer Pharmaceuticals Inc. (OPTR) (IPO)2/9$7$7.00$490%
Orexigen Therapeutics Inc. (OREX) (IPO)4/26$12$14.25$97+19%
Pharmasset Inc. (VRUS) (IPO)4/27$9$13.50$45+50%
JMP Securities LLCSirtris Pharmaceuticals Inc. (SIRT) (IPO)5/23$10$13.69$69+37%
JP Morgan SecuritiesAmicus Therapeutics Inc. (FOLD) (IPO)5/31$15$10.75$75-28%
Array BioPharma Inc. (ARRY) (co-lead)5/2$13$8.42$91-35%
Dyax Corp. (DYAX)7/13$3.67$3.66$44.4-0.3%
Genomic Health Inc. (GHDX) (co-lead)5/22$15.50$22.64$46.5+46%
Helicos BioSciences Corp. (HLCS) (co- lead; IPO)5/24$9$10.44$48.6+16%
Javelin Pharmaceuticals Inc. (AMEX:JAV) (lead)5/11$6$3.74$42.6-38%
Myriad Genetics Inc. (MYGN) (lead)2/8$35.90$46.42$107.7+29%
Onyx Pharmaceuticals Inc. (ONXX) 6/21$28$55.62$185+99%
Orexigen Therapeutics Inc. (OREX) (co- lead; IPO)4/26$12$14.25$97+19%
Sirtris Pharmaceuticals Inc. (SIRT) (lead; IPO)5/23$10$13.69$69+37%
Vanda Pharmaceuticals Inc. (VNDA) (co-lead)1/19$27.29$6.88$120.1-75%
Lazard Capital Markets LLCAcorda Therapeutics Inc. (ACOR)6/8$18.50$21.96$77.48+19%
Lazard Capital Markets LLCAmicus Therapeutics Inc. (FOLD) (IPO)5/31$15$10.75$75-28%
Clinical Data Inc. (CLDA) 7/24$22$22.25$75.9+1%
Dyax Corp. (DYAX)7/13$3.67$3.66$44.4-0.3%
Eurand International SpA (EURX) (IPO)5/17$16$15.80$112-1%
NeurogesX Inc. (NGSX) (IPO)5/2$11$6.36$44-42%
Poniard Pharmaceuticals Inc. (PARD) (co-lead)4/25$6.33$4.41$74.7-30%
Synta Pharmaceuticals Corp. (SNTA) (IPO)2/6$10$6.70$50-33%
Targanta Therapeutics Corp. (TARG) (IPO)10/10$10$9.04$57.5-10%
Leerink Swann & Co.Altus Pharmaceuticals Inc. (ALTU) 4/19$14.75$5.18$88.5-65%
ArQule Inc. (ARQL) 6/14$7.75$5.80$58.19-25%
ARYx Therapeutics Inc. (ARYX) (IPO)11/7$10$7.75$50-23%
Cardiome Pharma Corp. (CRME) 1/18$10.50$8.92$96.6-15%
Biodel Inc. (BIOD) (IPO)5/11$15$23.23$86.25+55%
Helicos BioSciences Corp. (HLCS) (IPO)5/24$9$10.44$48.6+16%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11$6$3.74$42.6-38%
Nanosphere Inc. (NSPH) (IPO)11/1$14$13.99$98-0.07%
Orexigen Therapeutics Inc. (OREX) (IPO)4/26$12$14.25$97+19%
Poniard Pharmaceuticals Inc. (PARD) 4/25$6.33$4.41$74.7-30%
Sucampo Pharmaceuticals Inc. (SCMP) (IPO)8/3$11.50$18.34$35.94+59%
Targanta Therapeutics Corp. (TARG) (IPO)10/10$10$9.04$57.5-10%
Lehman BrothersAcadia Pharmaceuticals Inc. (ACAD) (co-lead)4/5$15.50$11.07$102.3-29%
Eurand International SpA (EURX) (co- lead; IPO)5/17$16$15.80$112-1%
Genomic Health Inc. (GHDX) (co-lead)5/22$15.50$22.64$46.5+46%
Genoptix Inc. (GXDX) (IPO; lead)10/30$17$30.70$85.9+81%
Jazz Pharmaceuticals Inc. (JAZZ) (co- lead; IPO)6/1$18$14.70$108-18%
Rigel Pharmaceuticals Inc. (RIGL) (co-lead)5/3$9.75$25.39$48.8+160%
Sunesis Pharmaceuticals Inc. (SNSS) (lead)5/24$4.43$1.99$21-55%
Synta Pharmaceuticals Corp. (SNTA) (co- lead; IPO)2/6$10$6.70$50-33%
Maxim Group LLCImaRx Therapeutics Inc. (IMRX) (lead; IPO)7/25$5$1.93$15-61%
Response Genetics Inc. (RGDX) (lead; IPO)6/5$7$4.65$21-34%
MDB Capital Group LLCMediciNova Inc. (MNOV) (lead)1/29$12$4.60$12-62%
Mercer Capital Ltd.NeoStem Inc. (AMEX:NBS) (lead)8/14$4.96$1.34$6.3-73%
Merrill Lynch & Co.Alexza Pharmaceuticals Inc. (ALXA) (co-lead)4/27$10.25$8.09$70.73-21%
Amicus Therapeutics Inc. (FOLD) (co-lead; IPO)5/31$15$10.75$75-28%
Allos Therapeutics Inc. (ALTH) (lead)1/30$6$6.29$54+5%
Altus Pharmaceuticals Inc. (ALTU) (co-lead)4/19$14.75$5.18$88.5-65%
MAP Pharmaceuticals Inc. (MAPP) (IPO; co-lead)10/5$12$17.51$69+46%
Onyx Pharmaceuticals Inc. (ONXX) (co-lead)6/21$28$55.62$185+99%
Orexigen Therapeutics Inc. (OREX) (co- lead; IPO)4/26$12$14.25$97+19%
Merriman Curhan Ford & Co.A.P. Pharma Inc. (APPA) (lead)6/14$1.65$1.58$40.24-4%
Aradigm Corp. (OTC BB:ARDM)1/25$0.95$1.52$36.1+60%
Bionovo Inc. (BNVI) 10/26$2.50$1.71$25-32%
Neurobiological Technologies Inc. (NTII) (lead)10/30$2.75$3.08$60+12%
Pharmacopeia Inc. (PCOP) 5/2$5$4.77$40-5%
Montgomery & Co.Synta Pharmaceuticals Corp. (SNTA) (IPO)2/6$10$6.70$50-33%
Morgan StanleyAMAG Pharmaceuticals Inc. (AMAG) (co-lead) (formerly Advanced Magnetics Inc.)5/23$65.14$60.13$162.9-8%
Alexza Pharmaceuticals Inc. (ALXA) (co-lead)4/27$10.25$8.09$70.73-21%
Altus Pharmaceuticals Inc. (ALTU) (co-lead)4/19$14.75$5.18$88.5-65%
Amicus Therapeutics Inc. (FOLD) (co-lead; IPO)5/31$15$10.75$75-28%
ARYx Therapeutics Inc. (ARYX) (IPO; lead)11/7$10$7.75$50-23%
Biodel Inc. (BIOD) (co-lead; IPO)5/11$15$23.23$86.25+55%
Jazz Pharmaceuticals Inc. (JAZZ) (co- lead; IPO)6/1$18$14.70$108-18%
MAP Pharmaceuticals Inc. (MAPP) (IPO; co-lead)10/5$12$17.51$69+46%
NeurogesX Inc. (NGSX) (lead; IPO)5/2$11$6.36$44-42%
Onyx Pharmaceuticals Inc. (ONXX) (co-lead)6/21$28$55.62$185+99%
Progenics Pharmaceuticals Inc. (PGNX) 9/20$23.15$18.07$57-22%
Vanda Pharmaceuticals Inc. (VNDA) (co-lead)1/19$27.29$6.88$120.1-75%
Natexis Bleichroeder Inc.Biodel Inc. (BIOD) (IPO)5/11$15$23.23$86.25+55%
Jazz Pharmaceuticals Inc. (JAZZ) (IPO)6/1$18$14.70$108-18%
Vanda Pharmaceuticals Inc. (VNDA)1/19$27.29$6.88$120.1-75%
Needham & Co.La Jolla Pharmaceutical Co. (LJPC) (lead)3/30$6$3.92$40.12-35%
Oppenheimer & Co.Molecular Insight Pharmaceuticals Inc. (MIPI) (IPO)2/2$14$9.06$70-35%
Rosetta Genomics Ltd. (ROSG) (IPO)2/27$7$5.14$30.2-27%
Pacific Growth Equities3SBIO Inc. (SSRX) (IPO)2/7$16$14.88$115.2-7%
Alexza Pharmaceuticals Inc. (ALXA) 4/27$10.25$8.09$70.73-21%
Pacific Growth EquitiesAmicus Therapeutics Inc. (FOLD) (IPO)5/31$15$10.75$75-28%
Anesiva Inc. (ANSV) (lead)12/26$4.05$5.00$49.8+23%
Avigen Inc. (AVGN) (co-lead)4/26$6.94$4.25$27.6-39%
BioMimetic Therapeutics Inc. (BMTI) (co-lead)2/9$17.15$17.37$43.2+1%
Helicos BioSciences Corp. (HLCS) (IPO)5/24$9$10.44$48.6+16%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11$6$3.74$42.6-38%
NeurogesX Inc. (NGSX) (IPO)5/2$11$6.36$44-42%
Palatin Technologies Inc. (AMEX:PTN) (lead)2/16$2$0.20$27.5-90%
Pharmion Corp. (PHRM) 5/11$30$62.86$138+110%
Poniard Pharmaceuticals Inc. (PARD) 4/25$6.33$4.41$74.7-30%
Piper Jaffray & Co.Acadia Pharmaceuticals Inc. (ACAD) 4/5$15.50$11.07$102.3-29%
Acorda Therapeutics Inc. (ACOR)6/8$18.50$21.96$77.48+19%
Array BioPharma Inc. (ARRY) 5/2$13$8.42$91-35%
Genomic Health Inc. (GHDX) 5/22$15.50$22.64$46.5+46%
Nanosphere Inc. (NSPH) (IPO)11/1$14$13.99$98-0.07%
Optimer Pharmaceuticals Inc. (OPTR) (co-lead; IPO)2/9$7$7.00$490%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO)5/23$10$13.69$69+37%
Punk Ziegel & Co.Aradigm Corp. (OTC BB:ARDM) (lead)1/25$0.95$1.52$36.1+60%
Genitope Corp. (GTOP) (lead)4/27$3.85$0.74$23.08-81%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11$6$3.74$42.6-38%
Repros Therapeutics Inc. (RPRX) (co-lead)1/31$13.75$9.32$35.9-32%
RBC Capital MarketsAlexza Pharmaceuticals Inc. (ALXA) 4/27$10.25$8.09$70.73-21%
Molecular Insight Pharmaceuticals Inc. (MIPI) (co-lead; IPO)2/2$14$9.06$70-35%
Rodman & RenshawAcadia Pharmaceuticals Inc. (ACAD) 4/5$15.50$11.07$102.3-29%
Acorda Therapeutics Inc. (ACOR)6/8$18.50$21.96$77.48+19%
ArQule Inc. (ARQL) 6/14$7.75$5.80$58.19-25%
EpiCept Corp. (EPCT) (lead)10/10$1.88$1.27$8-32%
EpiCept Corp. (EPCT) (lead)12/4$1.50$1.27$4.95-15%
Optimer Pharmaceuticals Inc. (OPTR) (IPO)2/9$7.00$7.00$490%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO)5/23$10$13.69$69+37%
Susquehanna FinancialNeurogesX Inc. (NGSX) (IPO)5/2$11$6.36$44-42%
ThinkEquity Partners LLCAMAG Pharmaceuticals Inc. (AMAG) (formerly Advanced Magnetics Inc.)5/23$65.14$60.13$162.9-8%
Repros Therapeutics Inc. (RPRX)1/31$13.75$9.32$35.9-32%
Thomas Weisel PartnersEurand International SpA (EURX) (IPO)5/17$16$15.80$112-1%
Rigel Pharmaceuticals Inc. (RIGL) 5/3$9.75$25.39$48.8+160%
UBS Investment Bank3SBIO Inc. (SSRX) (lead; IPO)2/7$16$14.88$115.2-7%
Arena Pharmaceuticals Inc. (ARNA) (IPO; co-lead)11/2$9.91$7.83$109.01-21%
ArQule Inc. (ARQL) (co-lead)6/14$7.75$5.80$58.19-25%
Avigen Inc. (AVGN) (co-lead)4/26$6.94$4.25$27.6-39%
Bruker BioSciences Corp. (BRKR) (co-lead)2/13$7.10$13.30$17.96+87%
Cypress Bioscience Inc. (CYPB) (co-lead)5/30$15.50$11.03$72.9-29%
Dyax Corp. (DYAX) (lead)7/13$3.67$3.66$44.4-0.3%
Helicos BioSciences Corp. (HLCS) (co-lead; IPO)5/24$9$10.44$48.6+16%
Nastech Pharmaceutical Co. Inc. (NSTK) (lead)1/18$13.20$3.80$42.9-71%
Pharmasset Inc. (VRUS) (co-lead; IPO)4/27$9$13.50$45+50%
Progenics Pharmaceuticals Inc. (PGNX) (lead)9/20$23.15$18.07$57-22%
Protalix Bio- Therapeutics Inc. (AMEX:PLX) (lead)10/25$5$3.40$50-32%

Notes: * The financings in this chart are for public offerings in the U.S. only. The data were compiled primarily from BioWorld Financial Watch's monthly financing charts covering the period from Jan. 1 to Dec. 31, 2007. Those charts were published on Feb. 12, March 5, April 9, May 7, June 11, July 9, Aug. 6, Sept. 10, Oct. 8, Nov. 12, Dec. 10, 2007, and Jan. 7, 2008. The gross proceed totals listed reflect only those shares sold by companies. They include money raised through over allotment options, when disclosed.

** All prices in U.S. dollars. Offering price per share is adjusted to reflect any post-offering splits. Unless otherwise noted, shares are traded on the Nasdaq exchange. IPO = Initial Public Offering AMEX = American Stock Exchange; OTC BB = Over-the-Counter Bulleting Board.

No Comments