Underwriter Biotechnology Company Date priced Offering price per share** 9/14/07 Share Price Offering Gross (M)** After-Market Performance (%)

AG Edwards Securities BioMimetic Therapeutics Inc. (BMTI) 2/9 $17.15 $13.60 $43.2 -21%
La Jolla Pharmaceutical Co. (LJPC) 3/30 $6 $4.59 $40.12 -24%
Molecular Insight Pharmaceuticals Inc. (MIPI) (IPO) 2/2 $14 $7 $70 -50%
Allen & Co. LLC Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11 $6 $5.29 $42.6 -12%
Bank of America Securities Acadia Pharmaceuticals Inc. (ACAD) (co-lead) 4/5 $15.50 $15.38 $102.3 -1%
Acorda Therapeutics Inc. (ACOR) (co-lead) 6/8 $18.50 $17.30 $77.48 -6%
Allos Therapeutics Inc. (ALTH) 1/30 $6 $4.49 $54 -25%
Array BioPharma Inc. (ARRY) (co-lead) 5/2 $13 $12.76 $91 -2%
Biodel Inc. (BIOD) (co-lead; IPO) 5/11 $15 $18.95 $86.25 +26%
Eurand International SpA (EURX) (IPO) 5/17 $16 $14.55 $112 -9%
Onyx Pharmaceuticals Inc. (ONXX) 6/21 $28 $40.85 $185 +46%
Pharmasset Inc. (VRUS) (co-lead; IPO) 4/27 $9 $12.08 $45 +34%
Pharmion Corp. (PHRM) (co-lead) 5/11 $30 $42.26 $138 +41%
Vanda Pharmaceuticals Inc. (VNDA) 1/19 $27.29 $15.01 $120.1 -45%
Bear, Stearns & Co. AMAG Pharmaceuticals Inc.(AMAG) (co-lead) (formerly Advanced Magnetics Inc.) 5/23 $65.14 $55.18 $162.9 -15%
Bruker BioSciences Corp. (BRKR) (co-lead) 2/13 $7.10 $8.09 $17.96 +14%
Cardiome Pharma Corp. (CRME) (co-lead) 1/18 $10.50 $8.74 $96.6 -17%
Clinical Data Inc. (CLDA) (lead) 7/24 $22 $34.50 $75.9 +57%
Synta Pharmaceuticals Corp. (SNTA) (co-lead; IPO) 2/6 $10 $7.45 $50 -26%
Canaccord Adams Cardiome Pharma Corp. (CRME) 1/18 $10.50 $8.74 $96.6 -17%
Pharmacopeia Inc. (PCOP) 5/2 $5 $5.68 $40 +14%
Caris & Co. Response Genetics Inc.(RGDX) (IPO) 6/5 $7 $4.51 $21 -36%
C.E. Unterberg, Towbin Rosetta Genomics Ltd. (ROSG) (lead; IPO) 2/27 $7 $5.65 $30.2 -19%
Sunesis Pharmaceuticals Inc. (SNSS) 5/24 $4.43 $2.77 $21 -37%
CIBC World Markets 3SBIO Inc. (SSRX) (IPO) 2/7 $16 $11.12 $115.2 -31%
CIBC World Markets ArQule Inc. (ARQL) (co-lead) 6/14 $7.75 $7.74 $58.19 -0.1%
Cardiome Pharma Corp. (CRME) (co-lead) 1/18 $10.50 $8.74 $96.6 -17%
Cypress Bioscience Inc. (CYPB) (co-lead) 5/30 $15.50 $14.48 $72.9 -7%
Pharmacopeia Inc. (PCOP) (lead) 5/2 $5 $5.68 $40 +14%
Poniard Pharmaceuticals Inc. (PARD) (co-lead) 4/25 $6.33 $5.56 $74.7 -12%
Repros Therapeutics Inc. (RPRX) (co-lead) 1/31 $13.75 $10.28 $35.9 -25%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO) 5/23 $10 $14.39 $69 +44%
Sucampo Pharmaceuticals Inc. (SCMP)(IPO) 8/3 $11.50 $13.25 $35.94 +15%
Cowen & Co. Altus Pharmaceuticals Inc. (ALTU) 4/19 $14.75 $10.81 $88.5 -27%
Pharmion Corp. (PHRM) (co-lead) 5/11 $30 $42.26 $138 +41%
Sucampo Pharmaceuticals Inc. (SCMP) (lead; IPO) 8/3 $11.50 $13.25 $35.94 +15%
Sunesis Pharmaceuticals Inc. (SNSS) 5/24 $4.43 $2.77 $21 -37%
Credit Suisse Securities Jazz Pharmaceuticals Inc. (JAZZ) (IPO) 6/1 $18 $13.12 $108 -27%
Credit Suisse Securities Rigel Pharmaceuticals v 5/3 $9.75 $9.77 $48.8 +0.2%
Dawson James Securities A.P. Pharma Inc. (APPA) 6/14 $1.65 $2.35 $40.24 +42%
Deutsche Bank Securities Acadia Pharmaceuticals Inc. (ACAD) (co-lead) 4/5 $15.50 $15.38 $102.3 -1%
Acorda Therapeutics Inc. (ACOR) (co-lead) 6/8 $18.50 $17.30 $77.48 -6%
AMAG Pharmaceuticals Inc. (AMAG) (formerly Advanced Magnetics Inc.) 5/23 $65.14 $55.18 $162.9 -15%
BioMimetic Therapeutics Inc. (BMTI) (co-lead) 2/9 $17.15 $13.60 $43.2 -21%
Dyax Corp. (DYAX) 7/13 $3.67 $3.97 $44.4 +8%
Eurand International SpA (EURX) (co-lead; IPO) 5/17 $16 $14.55 $112 -9%
First Albany Capital BioMimetic Therapeutics Inc. (BMTI) 2/9 $17.15 $13.60 $43.2 -21%
Fortis Securities Acorda Therapeutics Inc. (ACOR) 6/8 $18.50 $17.30 $77.48 -6%
ArQule Inc. (ARQL) 6/14 $7.75 $7.74 $58.19 -0.1%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11 $6 $5.29 $42.6 -12%
Friedman, Billings, Ramsey Pharmion Corp. (PHRM) 5/11 $30 $42.26 $120 +41%
HSBC Securities (USA) Inc. Pharmion Corp. (PHRM) 5/11 $30 $42.26 $120 +41%
I-Bankers Securities ImaRx Therapeutics Inc. (IMRX) (IPO) 7/25 $5 $4.05 $15 -19%
Jefferies & Co. AMAG Pharmaceuticals Inc. (AMAG) (formerly Advanced Magnetics Inc.) 5/23 $65.14 $55.18 $162.9 -15%
Array BioPharma Inc. (ARRY) 5/2 $13 $12.76 $91 -2%
Cypress Bioscience Inc. (CYPB) (co-lead) 5/30 $15.50 $14.48 $72.9 -7%
Molecular Insight Pharmaceuticals Inc. (MIPI) (co-lead; IPO) 2/2 $14 $7 $70 -50%
Optimer Pharmaceuticals Inc. (OPTR) (co-lead; IPO) 2/9 $7 $8.07 $49 +15%
JMP Securities LLC Acadia Pharmaceuticals Inc. (ACAD) 4/5 $15.50 $15.38 $102.3 -1%
Allos Therapeutics Inc. (ALTH) 1/30 $6 $4.49 $54 -25%
Genomic Health Inc. (GHDX) 5/22 $15.50 $20.14 $46.5 +30%
Optimer Pharmaceuticals Inc. (OPTR) (IPO) 2/9 $7 $8.07 $49 +15%
Orexigen Therapeutics Inc. (OREX) (IPO) 4/26 $12 $13.94 $97 +16%
Pharmasset Inc. (VRUS) (IPO) 4/27 $9 $12.08 $45 +34%
JMP Securities LLC Sirtris Pharmaceuticals Inc. (SIRT) (IPO) 5/23 $10 $14.39 $69 +44%
JP Morgan Securities Amicus Therapeutics Inc. (FOLD) (IPO) 5/31 $15 $13.20 $75 -12%
Array BioPharma Inc. (ARRY) (co-lead) 5/2 $13 $12.76 $91 -2%
Dyax Corp. (DYAX) 7/13 $3.67 $3.97 $44.4 +8%
Genomic Health Inc. (GHDX) (co-lead) 5/22 $15.50 $20.14 $46.5 +30%
Helicos BioSciences Corp. (HLCS) (co-lead; IPO) 5/24 $9 $8.47 $48.6 -6%
Javelin Pharmaceuticals Inc. (AMEX:JAV) (lead) 5/11 $6 $5.29 $42.6 -12%
Myriad Genetics Inc. (MYGN) (lead) 2/8 $35.90 $47.10 $107.7 +31%
Onyx Pharmaceuticals Inc. (ONXX) 6/21 $28 $40.85 $185 +46%
Orexigen Therapeutics Inc. (OREX) (co-lead; IPO) 4/26 $12 $13.94 $97 +16%
Sirtris Pharmaceuticals Inc. (SIRT) (lead; IPO) 5/23 $10 $14.39 $69 +44%
Vanda Pharmaceuticals Inc. (VNDA) (co-lead) 1/19 $27.29 $15.01 $120.1 -45%
Lazard Capital Markets LLC Acorda

Therapeutics Inc. (ACOR)

6/8 $18.50 $17.30 $77.48 -6%
Amicus Therapeutics Inc. (FOLD) (IPO) 5/31 $15 $13.20 $75 -12%
Clinical Data Inc. (CLDA) 7/24 $22 $34.50 $75.9 +57%
Dyax Corp. (DYAX) 7/13 $3.67 $3.97 $44.4 +8%
Eurand International SpA (EURX) (IPO) 5/17 $16 $14.55 $112 -9%
NeurogesX Inc. (NGSX) (IPO) 5/2 $11 $9.41 $44 -14%
Poniard Pharmaceuticals Inc. (PARD) (co-lead) 4/25 $6.33 $5.56 $74.7 -12%
Synta Pharmaceuticals Corp. (SNTA) (IPO) 2/6 $10 $7.45 $50 -26%
Leerink Swann & Co. Altus Pharmaceuticals Inc. (ALTU) 4/19 $14.75 $10.81 $88.5 -27%
ArQule Inc. (ARQL) 6/14 $7.75 $7.74 $58.19 -0.1%
Cardiome Pharma Corp. (CRME) 1/18 $10.50 $8.74 $96.6 -17%
Biodel Inc. (BIOD) (IPO) 5/11 $15 $18.95 $86.25 +26%
Helicos BioSciences Corp. (HLCS) (IPO) 5/24 $9 $8.47 $48.6 -6%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11 $6 $5.29 $42.6 -12%
Orexigen Therapeutics Inc. (OREX) (IPO) 4/26 $12 $13.94 $97 +16%
Leerink Swann & Co. Poniard Pharmaceuticals Inc. (PARD) 4/25 $6.33 $5.56 $74.7 -12%
Sucampo Pharmaceuticals Inc. (SCMP (IPO) 8/3 $11.50 $13.25 $35.94 +15%
Lehman Brothers Acadia Pharmaceuticals Inc. (ACAD) (co-lead) 4/5 $15.50 $15.38 $102.3 -1%
Eurand International SpA (EURX) (co-lead; IPO) 5/17 $16 $14.55 $112 -9%
Genomic Health Inc. (GHDX) (co-lead) 5/22 $15.50 $20.14 $46.5 +30%
Jazz Pharmaceuticals Inc. (JAZZ) (co-lead; IPO) 6/1 $18 $13.12 $108 -27%
Rigel Pharmaceuticals Inc. (RIGL) (co-lead) 5/3 $9.75 $9.77 $48.8 +0.2%
Sunesis Pharmaceuticals Inc. (SNSS) (lead) 5/24 $4.43 $2.77 $21 -37%
Synta Pharmaceuticals Corp. (SNTA) (co-lead; IPO) 2/6 $10 $7.45 $50 -26%
Maxim Group LLC ImaRx Therapeutics Inc. (IMRX) (lead; IPO) 7/25 $5 $4.05 $15 -19%
Response Genetics Inc. (RGDX) (lead; IPO) 6/5 $7 $4.51 $21 -36%
MDB Capital Group LLC MediciNova Inc. (MNOV) (lead) 1/29 $12 $6.79 $12 -43%
Mercer Capital Ltd. NeoStem Inc. (AMEX:NBS) (lead) 8/14 $4.96 $4.82 $6.3 -3%
Merrill Lynch & Co. Alexza Pharmaceuticals Inc. (ALXA) (co-lead) 4/27 $10.25 $7.88 $70.73 -23%
Amicus Therapeutics Inc. (FOLD) (co-lead; IPO) 5/31 $15 $13.20 $75 -12%
Allos Therapeutics Inc. (ALTH) (lead) 1/30 $6 $4.49 $54 -25%
Altus Pharmaceuticals Inc. (ALTU) (co-lead) 4/19 $14.75 $10.81 $88.5 -27%
Onyx Pharmaceuticals Inc. (ONXX) (co-lead) 6/21 $28 $40.85 $185 +46%
Orexigen Therapeutics Inc. (OREX) (co-lead; IPO) 4/26 $12 $13.94 $97 +16%
Merriman Curhan Ford & Co. A.P. Pharma Inc. (APPA) (lead) 6/14 $1.65 $2.35 $40.24 +42%
Aradigm Corp. (OTC BB:ARDM) 1/25 $0.95 $1.35 $36.1 +42%
Pharmacopeia Inc. (PCOP) 5/2 $5 $5.68 $40 +14%
Montgomery & Co. Synta Pharmaceuticals Corp. (SNTA) (IPO) 2/6 $10 $7.45 $50 -26%
Morgan Stanley AMAG Pharmaceuticals Inc. (AMAG) (co-lead) (formerly Advanced Magnetics Inc.) 5/23 $65.14 $55.18 $162.9 -15%
Alexza Pharmaceuticals Inc. (ALXA) (co-lead) 4/27 $10.25 $7.88 $70.73 -23%
Altus Pharmaceuticals Inc. (ALTU) (co-lead) 4/19 $14.75 $10.81 $88.5 -27%
Amicus Therapeutics Inc. (FOLD) (co-lead; IPO) 5/31 $15 $13.20 $75 -12%
Biodel Inc. (BIOD) (co-lead; IPO) 5/11 $15 $18.95 $86.25 +26%
Jazz Pharmaceuticals Inc. (JAZZ) (co-lead; IPO) 6/1 $18 $13.12 $108 -27%
NeurogesX Inc. (NGSX) (lead; IPO) 5/2 $11 $9.41 $44 -14%
Onyx Pharmaceuticals Inc. (ONXX) (co-lead) 6/21 $28 $40.85 $185 +46%
Vanda Pharmaceuticals Inc. (VNDA) (co-lead) 1/19 $27.29 $15.01 $120.1 -45%
Natexis Bleichroeder Inc. Biodel Inc. (BIOD) (IPO) 5/11 $15 $18.95 $86.25 +26%
Jazz Pharmaceuticals Inc. (JAZZ) (IPO) 6/1 $18 $13.12 $108 -27%
Vanda Pharmaceuticals Inc. (VNDA) 1/19 $27.29 $15.01 $120.1 -45%
Needham & Co. La Jolla Pharmaceutical Co. (LJPC) (lead) 3/30 $6 $4.59 $40.12 -24%
Oppenheimer & Co. Molecular Insight Pharmaceuticals Inc. (MIPI) (IPO) 2/2 $14 $7 $70 -50%
Rosetta Genomics Ltd. (ROSG) (IPO) 2/27 $7 $5.65 $30.2 -19%
Pacific Growth Equities 3SBIO Inc. (SSRX) (IPO) 2/7 $16 $11.12 $115.2 -31%
Alexza Pharmaceuticals Inc. (ALXA) 4/27 $10.25 $7.88 $70.73 -23%
Amicus Therapeutics Inc. (FOLD) (IPO) 5/31 $15 $13.20 $75 -12%
Avigen Inc. (AVGN) (co-lead) 4/26 $6.94 $5.36 $27.6 -23%
BioMimetic Therapeutics Inc. (BMTI) (co-lead) 2/9 $17.15 $13.60 $43.2 -21%
Helicos BioSciences Corp. (HLCS) (IPO) 5/24 $9 $8.47 $48.6 -6%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11 $6 $5.29 $42.6 -12%
NeurogesX Inc. (NGSX) (IPO) 5/2 $11 $9.41 $44 -14%
Palatin Technologies Inc. (AMEX:PTN) (lead) 2/16 $2 $0.49 $27.5 -76%
Pharmion Corp. (PHRM) 5/11 $30 $42.26 $138 +41%
Poniard Pharmaceuticals Inc. (PARD) 4/25 $6.33 $5.56 $74.7 -12%
Piper Jaffray & Co. Acadia Pharmaceuticals Inc. (ACAD) 4/5 $15.50 $15.38 $102.3 -1%
Acorda Therapeutics Inc. (ACOR) 6/8 $18.50 $17.30 $77.48 -6%
Array BioPharma Inc. (ARRY) 5/2 $13 $12.76 $91 -2%
Genomic Health Inc. (GHDX) 5/22 $15.50 $20.14 $46.5 +30%
Optimer Pharmaceuticals Inc. (OPTR) (co-lead; IPO) 2/9 $7 $8.07 $49 +15%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO) 5/23 $10 $14.39 $69 +44%
Punk Ziegel & Co. Aradigm Corp. (OTC BB:ARDM) (lead) 1/25 $0.95 $1.35 $36.1 +42%
Genitope Corp. (GTOP) (lead) 4/27 $3.85 $3.57 $23.08 -7%
Javelin Pharmaceuticals Inc. (AMEX:JAV) 5/11 $6 $5.29 $42.6 -12%
Repros Therapeutics Inc. (RPRX) (co-lead) 1/31 $13.75 $10.28 $35.9 -25%
RBC Capital Markets Alexza Pharmaceuticals Inc. (ALXA) 4/27 $10.25 $7.88 $70.73 -23%
Molecular Insight Pharmaceuticals Inc. (MIPI) (co-lead; IPO) 2/2 $14 $7 $70 -50%
Rodman & Renshaw Acadia Pharmaceuticals Inc. (ACAD) 4/5 $15.50 $15.38 $102.3 -1%
Acorda Therapeutics Inc. (ACOR) 6/8 $18.50 $17.30 $77.48 -6%
ArQule Inc. (ARQL) 6/14 $7.75 $7.74 $58.19 -0.1%
Optimer Pharmaceuticals Inc. (OPTR) (IPO) 2/9 $7 $8.07 $49 +15%
Sirtris Pharmaceuticals Inc. (SIRT) (IPO) 5/23 $10 $14.39 $69 +44%
Susquehanna Financial NeurogesX Inc. (NGSX) (IPO) 5/2 $11 $9.41 $44 -14%
ThinkEquity

Partners LLC

AMAG Pharmaceuticals Inc. (AMAG) (formerly Advanced Magnetics Inc.) 5/23 $65.14 $55.18 $162.9 -15%
Repros Therapeutics Inc. (RPRX) 1/31 $13.75 $10.28 $35.9 -25%
Thomas Weisel Partners Eurand International SpA (EURX) (IPO) 5/17 $16 $14.55 $112 -9%
Rigel Pharmaceuticals Inc. (RIGL) 5/3 $9.75 $9.77 $48.8 +0.2%
UBS Investment Bank 3SBIO Inc. (SSRX) (lead; IPO) 2/7 $16 $11.12 $115.2 -31%
ArQule Inc. (ARQL) (co-lead) 6/14 $7.75 $7.74 $58.19 -0.1%
Avigen Inc. (AVGN) (co-lead) 4/26 $6.94 $5.36 $27.6 -23%
Bruker BioSciences Corp. (BRKR) (co-lead) 2/13 $7.10 $8.09 $17.96 +14%
Cypress Bioscience Inc. (CYPB) (co-lead) 5/30 $15.50 $14.48 $72.9 -7%
Dyax Corp. (DYAX) (lead) 7/13 $3.67 $3.97 $44.4 +8%
Helicos BioSciences Corp. (HLCS) (co-lead; IPO) 5/24 $9 $8.47 $48.6 -6%
UBS Investment Bank
Nastech Pharmaceutical Co. Inc. (NSTK) (lead) 1/18 $13.20 $13.74 $42.9 +4%
Pharmasset Inc. (VRUS) (co-lead; IPO) 4/27 $9 $12.08 $45 +34%

Notes:
* The financings in this chart are for public offerings in the U.S. only. The data were compiled primarily from BioWorld Financial Watch's monthly financing charts covering the period from Jan. 1 to Aug. 31, 2007. Those charts were published on Feb. 12, March 5, April 9, May 7, June 11, July 9, Aug. 6 and Sept. 10, 2007. The gross proceed totals listed reflect only those shares sold by companies. They include money raised through overallotment options, when disclosed.

** All prices in U.S. dollars. Offering price per share is adjusted to reflect any post-offering splits. Unless otherwise noted, shares are traded on the Nasdaq exchange.

IPO = Initial Public Offering

AMEX = American Stock Exchange