Company (Symbol)^#

Date Filed

Date Comm.

Shares/Units (M)

Price

Shares Out (M)^@

Lead, Other Underwriters

Gross (US$M)

Post-Offering Market Cap (M)^%

INITIAL OFFERINGS

Amsterdam Molecular Therapeutics Holding BV (the Netherlands; Euronext:AMT)¹

6/6/07

6/20/07

5S

€10

13.9

ABN AMRO Rothschild
Kempen & Co.

€50
($67)

€139
($186.2)

Evogene Ltd. (Israel; TASE:EVGN)²

6/12/07

6/12/07

3.8S, 3.9W (Series 1) and 3.4W (Series 2)

N/A

N/A

N/A

$8

N/A

Jazz Pharmaceuticals Inc. (JAZZ)³

3/9/07

6/1/07

6S

$18

24.55

Morgan Stanley
Lehman Bros. (co-lead)
Credit Suisse Sec.
Natexis Bleichroeder

$108

$441.9

Response Genetics Inc. (RGDX)⁴

12/21/06

6/5/07

3S

$7

10.24S

Maxim Group LLC
Caris & Co.

$21

$71.68

Total: $204M

Number of IPOs in June: 4

Average value of June IPOs: $51

Number of IPOs in 2007: 28

Total raised in IPOs in 2007: $1,448.3M

Average value of IPOs in 2007: $51.73M

FOLLOW-ON OFFERINGS

Company (Symbol)^#

Date Filed

Date Comm.

Shares/Units (M)

Price

Shares Out (M)^@

Lead, Other Underwriters

Gross (M)

Post-Offering Market Cap (M)^%

Acorda Therapeutics Inc. (ACOR)⁵

6/5/07

6/8/07

3.63S

$18.50

27.75

Bank of America Sec.
Deutsche Bank (co-lead)
Lazard Capital
Piper Jaffray
Fortis Securities
Rodman & Renshaw

$67.12

$513.38

A.P. Pharma Inc. (APPA)⁶

4/6/07

6/14/07

24.39S

$1.65

30.78

Merriman Curhan Ford
Dawson James Securities

$40.24

$50.8

ArQule Inc. (ARQL)⁷

6/6/07

6/14/07

7S

$7.75

42.8

UBS Investment Bank
CIBC World Markets (co-lead)
Leerink Swann & Co.
Fortis Securities LLC
Rodman & Renshaw LLC

$54.3

$331.7

Onyx Pharmaceuticals Inc. (ONXX)⁸

6/18/07

6/21/07

6.6S

$28

54.6

Morgan Stanley
Merrill Lynch (co-lead)
J.P. Morgan Securities
Banc of America Sec.

$185

$1,528.8

OVERALLOTMENTS

Pharmion Corp. (PHRM)⁹

5/3/07

6/7/07

0.6S

$30

36.75

Banc of America Sec.
Cowen and Co. (co-lead)
Pacific Growth Equities
Friedman, Billings, Ramsey
HSBC Securities (USA) Inc.

$18

$1,102.5

Total: $364.66M

Number of follow-on offerings in June: 4

Average value of June follow-ons: $91.17M

Number of follow-on offerings in 2007: 36

Total raised in follow-ons in 2007: $2,339.85M

Average value of follow-ons in 2007: $64.99M

Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

@ This column reflects the shares outstanding following the offering, when disclosed.

% Market capitalization is calculated based on the offering price.

Currency conversions are based on exchange rates at the time of the deal.

TASE = Tel Aviv Stock Exchange.

¹ Amsterdam's overallotment option: 750,000 shares.

² The full exercise price of both series of warrants would bring Evogene an additional $16.8M in capital.

³ Jazz's overallotment option: 900,000 shares.

⁴ Response Genetics' overallotment option: 450,000 shares.

⁵ Acorda's overallotment option: 562,500 shares.

⁶ Includes A.P.'s overallotment option: 3.1M shares.

⁷ ArQule's overallotment option: 1.05M shares.

⁸ Onyx's overallotment option: 990,000 shares.

⁹ Pharmion's total offering of 4.6M shares raised $138M gross.

Company (Symbol/Proposed Symbol)^#*

Date Filed

Shares/Units (M)

Price Range

Shares Out (M)^@

Lead, Other Underwriters

Value (M)

INITIAL OFFERINGS

Bioheart Inc. (BHRT)

2/13/07

N/A

N/A

21.5

BMO Capital Markets Corp.
Janney Montgomery Scott (co-lead)
Merriman Curhan Ford & Co.

$35

ImaRx Therapeutics Inc. (IMRX)¹

5/4/07

3S

$6.50-$7.50

9.1

Maxim Group LLC

$21

Light Sciences Oncology Inc. (LSON)

4/21/06

5.25S

$14-$16

18.5

Cowen & Co.
Wachovia Securities (co-lead)
Jefferies & Co.
Thomas Weisel Partners

$78.75

MAP Pharmaceuticals Inc. (MAPP)

6/18/07

N/A

N/A

N/A

Merrill Lynch & Co.
Morgan Stanley (co-lead)
Deutsche Bank Sec.

$86.25

Merrion Pharmaceuticals Ltd. (MERR)²

4/3/07

N/A

N/A

N/A

Punk, Ziegel & Co.
Goodbody Stockbrokers
Stanford Group Co.

$46

MonoSol Rx Inc. (MSRX)

5/14/07

N/A

N/A

N/A

Cowen & Co.
CIBC World Markets
Susquehanna Financial

$86.25

NovaBay Pharmaceuticals Inc. (AMEX:NBY; TSX:NBY)³

2/15/07

N/A

N/A

31.8

N/A

$23

NovaCardia Inc. (NCAR)

3/30/07

N/A

N/A

88.1

J.P. Morgan Securities Inc.
Credit Suisse Securities (co-lead)
Pacific Growth Equities LLC
Albany Capital Inc.

Sucampo Pharmaceuticals Inc. (SCMP)

6/19/06

N/A

N/A

N/A

Banc of America Securities
Deutsche Bank Securities (co-lead)
Leerink Swann & Co.

Targanta Therapeutics Corp. (TARG)

5/14/07

N/A

N/A

N/A

Credit Suisse Securities
Cowen & Co.
Lazard Capital Markets
Leerink Swann and Co.

$86.25

Company (Symbol/Proposed Symbol)^#*

Date Filed

Shares/Units (M)

Price Range

Shares Out (M)^@

Lead, Other Underwriters

Value (M)

FOLLOW-ON OFFERINGS

Chemokine Therapeutics Corp. (Canada; TSX:CTI; OTC BB:CHKT)

5/30/07

N/A

N/A

N/A

GMP Securities

$25

Neurochem Inc. (NRMX)

1/18/07

N/A

N/A

N/A

N/A

$102

WITHDRAWN OR POSTPONED

Company (Symbol/Proposed Symbol)^#*

Date Filed/Date Pulled

Shares/Units (M)

Price Range

Shares Out (M)^@

Lead, Other Underwriters

Value (M)

Aegerion Pharmaceuticals Inc. (AEGR)⁴

3/21/07
6/15/07

5S

$12-$14

18.6

Lehman Brothers
CIBC World Markets
Thomas Weisel Partners
C.E. Unterberg Towbin

$65

EndoCeutics Inc. (Canada; ENCX)⁵

2/27/07
6/27/07

5.75S

$7-$9

N/A

First Albany Capital
Oppenheimer & Co.
Stifel Nicolaus

$46

Quark Biotech Inc. (QURK)

3/30/07
6/28/07

5S

$12-$14

37.5

JPMorgan
CIBC World Markets
Banc of America Securities
C.E. Unterberg, Towbin

$65

Notes:

^# Unless otherwise indicated, shares are traded on the Nasdaq exchange; general shelf registration statements are not included until action is taken on the filing.

^* Stock symbols for companies seeking to complete IPOs are proposed.

^@ This column reflects the shares outstanding following the offering, when disclosed.

The value of all offerings is based on either the midpoint of the price range listed in the company's SEC filing or the most recent closing stock price before the offering was announced. In some cases, the company has not disclosed the number of shares to be offered or a price range. Then, the value is the maximum aggregate offering price listed in the SEC filing.

N/A = Not available, applicable or reported.

AMEX = American Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSX = Toronto Stock Exchange.

¹ ImaRx's overallotment option: 450,000 shares.

² Merrion plans to list American depositary shares on Nasdaq and ordinary shares in a secondary listing on the Irish Enterprise Exchange, both under the ticker "MERR."

³ NovaBay is seeking a dual listing on the American and Toronto stock exchanges.

⁴ Aegerion postponed the IPO due to market conditions.

⁵ EndoCeutics' withdrawal is based on current market conditions and adjustments made to the schedule of planned Phase III studies.