Molecular Insight Pharmaceuticals Inc., Cambridge, Mass., appointed Norman LaFrance senior vice president, clinical development and chief medical officer.

Neuralstem Inc., of Rockville, Md., appointed Scott Ogilvie and William Oldaker to its board.

OctoPlus NV, of Leiden, the Netherlands, appointed three new members to its scientific advisory board: Ab Osterhaus, Douwe Breimer and Peter van Brummelen.

Oculus Innovative Sciences Inc., of Petaluma, Calif., appointed Jay Birnbaum to its board.

Osprey Pharmaceuticals Ltd., of Montreal, named Jack Anthony to the newly created position of senior vice president of corporate development.

Prana Biotechnology Ltd., of Melbourne, Australia, hired Axel Unterbeck as chief strategic adviser and Steven Targum as chief medical adviser. It also promoted Dianne Angus to chief operating officer; Craig Ritchie to chief European clinical adviser, and Robert Cherny to head of research.

Proteolix Inc., of South San Francisco, hired Lori Kunkel as chief medical officer.

Protherics plc, of London, named Rolf Soderstrom finance director, and promoted President Saul Komisar to its board as an executive director.

Tissue Genesis Inc., of Honolulu, appointed Gary Gentzkow chief medical officer.