I. COMMENCED TRADING IN NOVEMBER

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units (M)

Price

Shares
Out
(M)@

Lead, Other
Underwriters

Gross
(M)

Post-
Offering
Market
Cap (M)%


INITIAL OFFERINGS

Biotec
Pharmacon ASA
(Norway; OSE:
BIOTEC)1

9/30/05

11/4/05

3.922S

NOK 24.50

21.49

DnB NOR Bank ASA

NOK96 (US$14.4)

NOK527

CombinatoRx
Inc.
(CRXX)2

12/13/04

11/9/05

6.9S

$7

23.22

SG Cowen & Co., Pacific Growth Equities (co-lead), Lazard Capital Markets, A.G. Edwards

$48.3

$162.5

ExonHit
Therapeutics
SA
(France;
Euronext:ALEHT)3

10/18/05

11/16/05

2.534S

€2.89

21.80

Société Générale

€7.3
(US$8.6)

€63.0

Total: $71.3M

Number of IPOs in November: 3

Average value of November IPOs: $23.77M

Number of IPOs in 2005: 31

Total raised in IPOs in 2005: $1,408.99M

Average value of IPOs in 2005: $45.45M

FOLLOW-ON OFFERINGS

Company
(Symbol)#

Date
Filed

Date
Comm.

Shares/
Units(M)

Price

Shares
Out
(M)@

Lead, Other
Underwriters

Gross
(M)

Post-
Offering
Market
Cap (M)%


Digene
Corp.
(DIGE)4

12/15/04

11/16/05

2S

$28

22.14

JP Morgan Securities, Thomas Weisel Partners (co-lead), Goldman, Sachs & Co., SG Cowen & Co.

$56

$619.9

Durect Corp.
(DRRX)5

10/27/05

11/2/05

8.22S

$5

60.68

Morgan Stanley & Co., JP Morgan Securities (co-lead), CIBC World Markets Corp., WR Hambrecht + Co.

$41.1

$303.4

Myriad
Genetics Inc.
(MYGN)6

4/20/05

11/3/05

8.05S

$18.50

39.00

JP Morgan Securities, Bear, Stearns & Co. (co-lead), UBS Securities (co-lead), Piper Jaffray & Co., First Albany Capital, JMP Securities

$148.9

$721.5

Onyx
Pharmaceuticals
Inc.
(ONXX)7

1/31/05

11/18/05

5S

$25.25

40.39

Morgan Stanley & Co., Merrill Lynch & Co. (co-lead)

$126.3

$1,019.8

Pharmaxis
Ltd.
(Australia;
PXSL)8

8/31/05

11/8/05

19.5S

$1.61

174.4

CIBC World Markets, JMP Securities

$31.4

$280.8

Point
Therapeutics
Inc.
(POTP)9

12/17/04

11/22/05

8.05S

$3

31.54

Pacific Growth Equities, CIBC World Markets (co-lead)

$24.15

$94.6

Senomyx
Inc.
(SNMX)10

10/24/05

11/4/05

4.05S

$14.60

29.66

Deutsche Bank Securities

$59

$433.0

OVERALLOTMENT OPTIONS

Dynavax
Technologies
Inc.
(DVAX)11

8/29/05

11/10/05

0.72S

$6.25

30.47

Bear, Stearns & Co., CIBC World Markets, Pacific Growth Equities

$4.5

$190.4

Total: $491.35M

Number of follow-on offerings in November: 7

Average value of November follow-ons: $69.55M

Number of follow-on offerings in 2005: 54

Total raised in follow-ons in 2005: $3,796.81M

Average value of follow-ons in 2005: $70.31M

II. FILED AND PENDING

Company
(Symbol/
Proposed
Symbol)#*

Date Filed

Shares/Units (M)

Price Range

Shares Out (M)@

Lead, Other Underwriters

Value (M)


INITIAL OFFERINGS

Acorda
Therapeutics
Inc.
(ACOR)1

10/5/05

N/A

N/A

N/A

Banc of America, Lazard Capital Markets, Piper Jaffray & Co., SG Cowen & Co.

$86.75

AlgoRx
Pharmaceuticals
Inc.
(AGRX)2

11/29/04

6.8S

$7-$8

N/A

Credit Suisse First Boston, Lazard Freres & Co., Citigroup (co-lead), Piper Jaffray & Co.

$51

Altus
Pharmaceuticals
Inc.
(ALTU)3

10/17/05

N/A

N/A

N/A

Merrill Lynch & Co., Morgan Stanley (co-lead), SG Cowen & Co.

$115

BioNumerik
Pharmaceuticals
Inc.
(BNPI)4

6/9/04

5S

$14-$16

N/A

UBS Investment Bank, Needham & Co., Leerink Swann & Co., Punk, Ziegel & Co.

$75

Corus
Pharma Inc.
(CSPH)5

8/27/04

N/A

N/A

N/A

Merrill Lynch & Co., Pacific Growth Equities, SunTrust Robinson Humphrey, JMP Securities

$100

Glycotex Inc.
(GLTX)6

9/9/05

N/A

N/A

N/A

Janney Montgomery Scott

$39

Iomai Corp.
(IOMI)7

10/3/05

N/A

N/A

N/A

UBS Investment Bank, SG Cowen & Co., First Albany Capital, Susquehanna Financial

$86.25

Molecular
Insight
Pharmaceuticals
Inc.
(MIPI)8

11/8/05

N/A

N/A

N/A

Piper Jaffray & Co., SG Cowen & Co. (co-lead), Oppenheimer & Co., Roth Capital Partners

$57.5

Prestwick
Pharmaceuticals
Inc.
(PWCK)9

4/22/05

N/A

N/A

N/A

UBS Investment Bank, Deutsche Bank Securities, CIBC World Markets

$74.75

SGX
Pharmaceuticals
Inc.
(SGXP)10

9/2/05

N/A

N/A

N/A

CIBC World Markets, Piper Jaffray & Co. (co-lead), JMP Securities

$80.5

Somaxon
Pharmaceuticals
Inc.
(SOMX)11

10/7/05

N/A

N/A

N/A

Morgan Stanley & Co., JP Morgan Securities (co-lead), Piper Jaffray & Co., Thomas Weisel Partners

$86.25

Valera
Pharmaceuticals
Inc.
(VLRX)12

3/14/05

N/A

N/A

N/A

UBS Investment Bank, Banc of America (co-lead), First Albany Capital, Fortis Securities

$74.75

Voyager
Pharmaceutical
Corp.
(VYGR)13

9/9/05

5.9S

$15-$19

N/A

WR Hambrecht + Co.

$100.3

FOLLOW-ON OFFERINGS

Dendreon
Corp.
(DNDN)14

10/26/05

10S

$5.90

N/A

Banc of America Securities, JMP Securities, Lazard Capital Markets

$59

Medivation
Inc.
(OTC BB:
MDVN)15

10/6/05

8.7S

$2.75

N/A

Adams Harkness

$23.9

ViroPharma
Inc.
(VPHM)16

10/19/01

7S

$17

N/A

Goldman, Sachs & Co., Piper Jaffray & Co. (co-lead), SG Cowen & Co., Lazard Capital Markets

$119

WITHDRAWN AND POSTPONED

Company
(Symbol/
Proposed
Symbol)#*

Date
Filed/
Date
Pulled

Shares/
Units
(M)

Price
Range

Shares
Out
(M)
@

Lead, Other Underwriters

Value
(M)


Reliant
Pharmaceuticals
Inc.
(NYSE:RRX)17

5/20/05/ 11/17/05

N/A

N/A

N/A

Goldman, Sachs & Co., Banc of America Securities, Deutsche Bank Securities, JP Morgan Securities, William Blair & Co., Lazard Capital Markets

$300


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange; general shelf registration statements are not included until action is taken on the filing.

* Stock symbols for companies seeking to complete IPOs are proposed.

@ This column reflects the shares outstanding following the offering, when disclosed.

N/A = Not available, applicable or reported.

NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board.

1. Acorda filed to raise up to $86.75M in an IPO. It withdrew a previous IPO filing in January 2004.

2. AlgoRx filed to raise up to $75M in an IPO. It reduced the price range in February. The value is based on the midpoint of that price range. It entered a merger agreement with the public company Corgentech Inc. on Sept. 26.

3. Altus filed to raise up to $115M in an IPO.

4. BioNumerik filed to raise up to $86.25M in an IPO. It later proposed selling 5M shares at $14 to $16 per share. The value is based on the midpoint of that price range.

5. Corus filed to raise up to $100M in an IPO.

6. Glycotex, a subsidiary of Novogen Ltd., filed to raise up to $39M in an IPO.

7. Iomai filed to raise up to $86.25M in an IPO.

8. Molecular Insight filed to raise up to $57.5M in an IPO.

9. Prestwick filed to raise up to $74.75M in an IPO.

10. SGX filed to raise up to $80.5M in an IPO.

11. Somaxon filed to raise up to $86.25M in an IPO.

12. Valera filed to raise up to $74.75M in an IPO.

13. Voyager filed to raise up to $128.9M in an IPO. It proposed the price range on Oct. 14. The value is based on the midpoint of that range.

14. Dendreon on Nov. 28 registered to sell 10M shares from an existing shelf registration. The value is based on the Nov. 28 closing price.

15. Medivation registered to sell 8.7M shares in a follow-on offering. The value is based on the Oct. 14 closing price.

16. ViroPharma on Nov. 28 registered to sell 7M shares from an existing shelf registration. The value is based on the Nov. 28 closing price.

17. Reliant cited market conditions in withdrawing its proposed IPO.