I. COMMENCED TRADING IN DECEMBER

Company (Symbol)#

Date Filed

Date Comm.

Shares/Units (M)

Price

Shares Out (M)@

Lead, Other Underwriters

Gross (M)

Post-Offering Market Cap (M)%


INITIAL OFFERINGS

BioAlliance Pharma SA (France; Euronext:BIO)1

11/17/05

12/7/05

2.256S

€13.30

8.27

Bryan Garnier & Co.
ING Securities (co-lead)

€30
(US$35.5)

€110

Somaxon Pharmaceuticals Inc. (SOMX)2

10/7/05

12/15/05

5S

$11

18.03

Morgan Stanley & Co.
JP Morgan Securities (co-lead)
Piper Jaffray & Co.
Thomas Weisel Partners

$55

$198.3

OVERALLOTMENT OPTIONS

ExonHit Therapeutics SA (France; Euronext:ALEHT)3

10/18/05

12/10/05

0.173S

€2.89

21.97

Société Générale

€0.5
(US$0.6)

€63.5

Total: $91.1M

Number of IPOs in December: 2

Average value of December IPOs: $45.25M

Number of IPOs in 2005: 33

Total raised in IPOs in 2005: $1,500.09M

Average value of IPOs in 2005: $45.46M

FOLLOW-ON OFFERINGS

Company (Symbol)#

Date Filed

Date Comm.

Shares/Units (M)

Price

Shares Out (M)@

Lead, Other Underwriters

Gross (M)

Post-Offering Market Cap (M)%


Biopure Corp. (BPUR)4

12/1/05

12/21/05

10.12S

$0.68

34.48

Dawson James Securities
Noble International (co-lead)

$6.9

$23.5

Dendreon Corp. (DNDN)5

10/26/05

12/7/05

11.5S

$4.50

70.86

Banc of America Securities
JMP Securities
Lazard Capital Markets

$51.8

$318.9

Medivation Inc. (OTC BB: MDVN)6

10/6/05

12/15/05

5.635S

$2

24.76

Adams Harkness

$11.27

$49.5

OxiGene Inc. (OXGN)7

12/1/05

12/15/05

7.475S

$3.65

28.04

SG Cowen & Co.
Lazard Capital Markets (co-lead)

$27.3

$102.3

ViroPharma Inc. (VPHM)8

10/19/01

12/7/05

10.35S

$16.75

68.26

Goldman, Sachs & Co.
Piper Jaffray & Co. (co-lead)
SG Cowen & Co.
Lazard Capital Markets

$173.4

$1,143.6

OVERALLOTMENT OPTIONS

Digene Corp. (DIGE)9

12/15/04

12/15/05

0.3S

$28

22.44

JP Morgan Securities
Thomas Weisel Partners (co-lead)
Goldman, Sachs & Co.
SG Cowen & Co.

$8.4

$628.3

Point Therapeutics Inc. (POTP)10

12/17/04

12/2/05

1.21S

$3

32.75

Pacific Growth Equities
CIBC World Markets (co-lead)

$3.6

$98.3

Total: $282.67M

Number of follow-on offerings in December: 5

Average value of December follow-ons: $54.13M

Number of follow-on offerings in 2005: 59

Total raised in follow-ons in 2005: $4,079.48M

Average value of follow-ons in 2005: $69.14M


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

@ This column reflects the shares outstanding following the offering, when disclosed.

% Market capitalization is calculated based on the offering price. Currency conversions are based on exchange rates at the time of the deal.

1 BioAlliance raised 30M in an IPO on the Euronext market in France. Underwriters have an option to purchase up to 338,400 additional shares to cover overallotments.

2 Somaxon raised $55M in an IPO of 5M shares. Underwriters have an option to purchase up to 750,000 additional shares to cover overallotments.

3 The underwriter of ExonHit s IPO in November exercised its option on 172,500 additional shares. Gross proceeds were about 7.8M, including 1.384M shares sold to BioMerieux at the offer price.

4 Biopure raised about $6.9M from a follow-on offering of 10.12M shares. The deal also included 10.12M warrants exercisable at $0.85 per share. Totals include the underwriters purchase of 1.32M additional shares and warrants to cover overallotments.

5 Dendreon raised $51.8M in a follow-on offering of 1 1.5M shares. The totals include the underwriters purchase of 1.5M shares per their overallotment option.

6 Medivation raised $1 1.27M in a follow-on offering of 5.635M shares. The totals include the underwriter s purchase of 1.5M shares per its overallotment option.

7 OxiGene raised $27.3M in a follow-on offering of 7.475M shares. The totals include the underwriters purchase of 0.975M shares per their overallotment option.

8 ViroPharma raised $173.4M in a follow-on offering of 10.35M shares. The totals include the underwriters purchase of 1.35M shares per their overallotment option.

9 Underwriters of Digene s follow-on offering in November exercised their option to purchase another 300,000 shares from the company. The offering totaled 9.275M shares and about $27.8M in gross proceeds.

10 Underwriters of Point Therapeutics follow-on offering in November exercised their option to purchase another 1.21M shares. Proceeds to Digene were $64.4M through the sale of 2.3M shares. Totals do not include 1.2M shares sold in the deal by Armonk Partners.

II. FILED AND PENDING

Company (Symbol/Proposed Symbol)#*

Date Filed

Shares/Units (M)

Price Range

Shares Out (M)@

Lead, Other Underwriters

Value (M)


INITIAL OFFERINGS

Acorda Therapeutics Inc. (ACOR)1

10/5/05

N/A

N/A

N/A

Banc of America
Lazard Capital Markets
Piper Jaffray & Co.
SG Cowen & Co.

$86.75

Alexza Pharmaceuticals Inc. (ALXA)2

12/22/05

N/A

N/A

N/A

Piper Jaffray & Co.
Pacific Growth Equities (co-lead)
RBC Capital Markets
JMP Securities

$86.25

Altus Pharmaceuticals Inc. (ALTU)3

10/17/05

N/A

N/A

N/A

Merrill Lynch & Co.
Morgan Stanley (co-lead)
SG Cowen & Co.

$115

BioNumerik Pharmaceuticals Inc. (BNPI)4

6/9/04

5S

$14-$16

N/A

UBS Investment Bank
Needham & Co.
Leerink Swann & Co.
Punk, Ziegel & Co.

$75

Corus Pharma Inc. (CSPH)5

8/27/04

N/A

N/A

N/A

Merrill Lynch & Co.
Pacific Growth Equities
SunTrust Robinson Humphrey
JMP Securities

$100

Glycotex Inc. (GLTX)6

9/9/05

N/A

N/A

N/A

Janney Montgomery Scott

$39

Iomai Corp. (IOMI)7

10/3/05

N/A

N/A

N/A

UBS Investment Bank
SG Cowen & Co.
First Albany Capital
Susquehanna Financial

$86.25

Molecular Insight Pharmaceuticals Inc. (MIPI)8

11/8/05

N/A

N/A

N/A

Piper Jaffray & Co.
SG Cowen & Co. (co-lead)
Oppenheimer & Co.
Roth Capital Partners

$57.5

SGX Pharmaceuticals Inc. (SGXP)9

9/2/05

N/A

N/A

N/A

CIBC World Markets
Piper Jaffray & Co. (co-lead)
JMP Securities

$80.5

Valera Pharmaceuticals Inc. (VLRX)10

3/14/05

N/A

N/A

N/A

UBS Investment Bank
Banc of America (co-lead)
First Albany Capital
Fortis Securities

$74.75

Vanda Pharmaceuticals Inc. (VNDA)11

12/29/05

N/A

N/A

N/A

JP Morgan Securities
Banc of America (co-lead)
Thomas Weisel Partners

$75

WITHDRAWN AND POSTPONED

Company (Symbol/Proposed Symbol)#*

Date Filed/Date Pulled

Shares/Units (M)

Price Range

Shares Out (M)@

Lead, Other Underwriters

Value (M)


AlgoRx Pharmaceuticals Inc. (AGRX)12

11/29/04
12/16/05

6.8S

$7-$8

N/A

Credit Suisse First Boston
Citigroup (co-lead)
Piper Jaffray & Co.
Lazard Freres & Co.

$51

Prestwick Pharmaceuticals Inc. (PWCK)13

4/22/05
12/21/05

N/A

N/A

N/A

UBS Investment Bank
Deutsche Bank Securities
CIBC World Markets

$74.75

Voyager Pharmaceutical Corp. (VYGR)14

9/9/05
12/13/05

4.5S

$11-$15

N/A

WR Hambrecht + Co.

$58.5


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange; general shelf registration statements are not included until action is taken on the filing.

* Stock symbols for companies seeking to complete IPOs are proposed.

@ This column reflects the shares outstanding following the offering, when disclosed.

N/A = Not available, applicable or reported.

1 Acorda filed to raise up to $86.75M in an IPO. It withdrew a previous IPO filing in January 2004.

2 Alexza filed to raise up to $86.25M in an IPO.

3 Altus filed to raise up to $1 15M in an IPO.

4 BioNumerik filed to raise up to $86.25M in an IPO. It later proposed selling 5M shares at $1 4 to $1 6 per share. The value is based on the midpoint of that price range.

5 Corus filed to raise up to $100M in an IPO.

6 Glycotex, a subsidiary of Novogen Ltd., filed to raise up to $39M in an IPO.

7 Iomai filed to raise up to $86.25M in an IPO.

8 Molecular Insight filed to raise up to $57.5M in an IPO.

9 SGX filed to raise up to $80.5M in an IPO.

10 Valera filed to raise up to $74.75M in an IPO.

11 Vanda filed to raise up to $75M in an IPO.

12 AlgoRx filed to raise up to $75M in an IPO. The filing was withdrawn following its merger with the public company Corgentech Inc.

13 Prestwick cited market conditions in withdrawing its IPO filing.

14 Voyager withdrew its IPO filing, after previously lowering the price range and shares offered.