Total: $1,796.73M

Company
(Symbol)#

Type Of
Financing

Number
Of Shares,
Units Or Warrants
(M)

Amount
Raised
(M)

Investors; Placement Agents; Details (Date)@

Acura
Pharmaceuticals
Inc.
(OTC BB:ACUR)

Bridge loan

N/A

$1

The one-year, 10% loan was provided by Essex Woodlands Health Ventures V LP and funds from Care Capital and Galen Partners (6/22)

Advanced
Magnetics
Inc.
(AMEX:AVM)

Private
placement of
stock and
warrants

1.8S and 0.36W

$17.1

Shares in the registered direct sale were priced at $9.50 each; warrants are exercisable at $13 per share; investing were affiliates of Great Point Partners LLC and Vivo Ventures LLC, and a company director; the deal closed in two tranches (6/1 and 6/2)

Aeolus
Pharmaceuticals
Inc.
(OTC BB:AOLS)

Private
placement of
convertible
notes and
warrants

N/A and ND

$2.5

The 6% notes are convertible into shares at $1 per share, as are the five-year warrants that accompanied them; the company has an option to pay the dividend in cash or shares; investors included Xmark Opportunity Funds and Biotechnology Value Fund LP (6/27)

Auxilium
Pharmaceuticals
Inc.
(AUXL)

Private placement of stock and warrants

8.2S and 2.06W

$40.4

The shares were sold at about $4.90 each, and the warrants are exercisable at $5.84 per share; Deutsche Bank Securities Inc. was lead placement agent (6/29)

Bavarian
Nordic A/S
(Denmark; CSE:
BAVA)

Rights issue

1.16S

DKK416.7 (US$67.5)

Among those participating in the fully subscribed rights issue were existing shareholders A.J. Aamund A/S and LD Pensions (6/23)

BioDelivery
Sciences
International
Inc.
(BDSI)

Convertible debt deal

N/A

$2.5

Laurus Master Fund Ltd., in a deal very similar to one completed in February with BDSI, bought a three-year, prime-plus-2% note convertible into common stock at $3.10 per share; Laurus also got warrants to purchase up to 483,871 shares at $3.88 per share (6/3)

Bionomics Ltd.
(Australia;
ASX:BNO)

Private placement of stock

44.4S

A$6 (US$4.6)

Each share includes two-thirds of an option on an additional share at A$0.22 per full share; Intersuisse Corporate Pty. Ltd. managed the deal (6/27)

BioTie
Therapies Oyj
(Finland; HSE:
BTH1V)

Private placement of stock

8.77S

€6.6 (US$8)

Among investors subscribing in the stock sale were Juha Jouhki, Thominvest Oy, Dreadnought Finance Oy and BioFund Ventures III (6/22)

Cephalon
Inc.
(CEPH)

Private placement of convertible notes

N/A

$800

The 2% senior subordinated notes due 2015 are convertible at $46.70 per common share; the total does not include $120M in notes purchased per the underwriters' overallotment option on July 1; the notes were sold from a shelf registration (6/2)

CombiMatrix
Group
(CBMX)

Private placement of stock

1.3S

$2.9

The stock was sold from a shelf registration in a registered direct offering at $2.25 per share (6/30)

Corautus
Genetics Inc.
(VEGF)

Private placement of stock and loan agreement

4.7S

$23

Boston Scientific Corp. and a group of private investors are purchasing 4.7M shares for $18M; separately, an amended loan deal with Boston Scientific makes $5M available to Corautus (6/28)

Critical
Therapeutics
Inc.
(CRTX)

Private placement of stock and warrants

9.95S and 3.48W

$54.5

Institutional and other accredited investors bought the shares at $5.48 each; the five-year warrants are exercisable at $6.58 per share (6/7)

Crucell NV
(the Netherlands;
CRXL)

Private
placement of
stock

3.6S

€52.2 (US$64)

Crucell sold the shares at €14.50 each in a private placement; Fortis Bank was the sole manager in the deal (5/10)&

CV
Therapeutics
Inc.
(CVTX)

Public offering of convertible notes

N/A

$130

The 3.25% convertible senior subordinated notes due 2013 were sold in a public offering; they are convertible into stock at about $27 per share; underwriters were Lehman Brothers, Merrill Lynch & Co., Citigroup and Deutsche Bank Securities; the total does not include the July 1 purchase of $19.5M in notes per the underwriters' overallotment option (6/29)

Evotec AG
(Germany;
FSE:EVT)

Private placement of
stock

10.46S

€28.4 (US$34.5)

Evotec sold the shares in a fully subscribed placement at €2.72 per share (6/24)

Exelixis Inc.
(ELEX)

Funding vehicle

N/A

$40

Symphony Capital Partners provided $40M for further development of XL647, XL999 and XL784; it formed Symphony Evolution Inc., which has an option to call an additional $20M to $40M within one year (6/13)

Galapagos NV
(Belgium;
Euronext:GLPG)

Warrants exercise

0.082S

€0.4 (US$0.5)

Galapagos placed 82,562 shares in connection with the exercise of warrants, which closed at the same time as it completed its €22M IPO (6/3)

Generex
Biotechnology
Corp.
(Canada;
GNBT)

Private placement of convertible notes and warrants

N/A and 2.44W

$2

Holders of 6%, 15-month notes purchased in 2004 bought another $2M in notes; they initially are convertible into stock at $0.60 per share; investors also got five-year warrants to purchase 2.44M shares at $0.82 each (6/16)

Helix
BioMedix Inc.
(OTC BB:HXBM)

Warrants exchange

4.95S

$1.5

Warrants for the purchase of about 9.95M shares were properly tendered in the offer, which expired on May 31 (6/1)

Hollis-Eden
Pharmaceuticals
Inc.
(HEPH)

Private placement of stock and warrants

1.33S and 0.267W

$10

A single institutional investor purchased the shares at $7.50 each; the four-year warrants are exercisable at $10 per share; Rodman & Renshaw LLC was placement agent (6/1)

Immunicon
Corp.
(IMMC)

Private placement of stock

4.138S

$19.7

The shares were sold from a shelf registration at $4.75 each; Legg Mason Wood Walker Inc. was lead placement agent; First Albany Capital Inc. was co-placement agent (6/30)

Invitrogen
Corp.
(IVGN)

Private placement of convertible notes

N/A

$350

The 3.25% senior convertible notes due 2025 were sold to institutional buyers; the total includes their purchase of $25M in notes per their option; the notes are convertible in some circumstances into cash or stock at an initial price of $98.25 per share (6/14)

Lev
Pharmaceuticals
Inc.
(OTC BB:LEVP)

Private placement of stock and warrants

5.04S and 2.52W

$5.04

The securities were sold as units priced at $50,000 each; the five-year warrants are exercisable at $1.35 per share; placement agent Laidlaw & Co. (UK) Ltd. also received 681,044 warrants exercisable at $1.35 per share (6/6)

Peregrine
Pharmaceuticals
Inc.
(PPHM)

Private placement of stock

8S

$6.72

The shares were sold from a shelf registration to a single investor (6/23)

Pharma-
Frontiers Corp.
(OTC BB:PFTR)

Private placement of stock and warrants

3.387S and 9.3W

$5.08

Investors purchased about 3.387M units at $1.50 per unit; each unit comprises one share of common stock and three types of warrants to purchase 2.75 shares at undisclosed prices (6/20)

Procyon
Biopharma
Inc.
(Canada;
TSE:PBP)

Private placement of convertible notes

N/A

C$3.5 (US$2.8)

The five-year, 7% notes are convertible into stock at $0.45 per share; investors also got warrants equal to 50% of the number of shares that could be issued; investors included Desjardins Venture Capital, Fonds Bio-Innovation and Societe Innovatech Quebec et Chaudieres-Appalaches; Dundee Securities Corp. was placement agent (6/30)

RegeneRx Bio-
pharmaceuticals
Inc.
(AMEX:RGN)

Private placement of stock

1.538S

$5

Affiliates of Sigma-Tau Group purchased the shares at $3.25; Sigma-Tau owned about 30% of RegeneRx before the deal (6/23)

Tm Bioscience
Corp.
(Canada;
TSE:TMC)

Warrants exercise

ND

C$3.8 (US$3.1)

The warrants were issued in two private placements in 2003; any remaining warrants relating to those financings have now expired (6/29)

Tripep AB
(Sweden; SSE:
TPEP)

Rights issue and warrants placement

5.08S and 2.54W

SEK28 (US$3.6)

Dormant Properties AB underwrote shares not taken up by existing shareholders, and retained its 21% stake; warrants are exercisable at SEK8 and SEK12 per share (6/17)

Tripep AB
(Sweden; SSE:
TPEP)

Private placement of stock

0.256S

SEK2.18 (US$0.29)

A private investor purchased the shares at SEK8.50 each, and agreed to exercise all preference rights on the shares in the upcoming rights issue (6/10)

Valentis Inc.
(VLTS)

Private placement of stock and warrants

1.68S and 0.84W

$4.2

The stock and warrants were sold as a unit at $2.50 per unit; the five-year warrants are exercisable at $3.51 per share (6/27)

Viventia
Biotech Inc.
(Canada; TSE:VBI)

Bridge loans

N/A

C$4.8(US$3.9)

Viventia Chairman Leslie Dan provided loans of C$1.5M, C$1.5M and C$1.8 that carry a 4.5% annual interest rate (6/17)

Xechem
International
Inc.
(OTC BB:XKEM)

Sale of minority interest

N/A

$2.3

Xechem sold most of its interest in CepTor Corp., which it spun off in February; CepTor purchased the shares; Xechem still has 500,000 CepTor shares, or 15% of its original investment (6/29)

Zeltia SA
(Spain; SPE:ZEL)

Private placement of stock

10.75S

€65 (US$78.5)

The shares were sold at €6.05 each; proceeds will be used to fund work at subsidiary PharmaMar SA; HSBC Securities was placement agent (6/23)


Notes:

This chart does not include real estate or manufacturing plant financings.

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

& = Deal occurred in May but was not included in the previous chart.

Currency conversions are based on exchange rates at the time of the deal.

N/A = Not applicable; ND = Not disclosed.

AMEX = American Stock Exchange; ASX = Australian Stock Exchange; CSE = Copenhagen Stock Exchange; FSE = Frankfurt Stock Exchange; HSE = Helsinki Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; SPE = Spanish Stock Exchange; SSE = Stockholm Stock Exchange; TSE = Toronto Stock Exchange.