Biotech Co.*
(Country;
Symbol)

Pharma Co.
(Country)

Product

Terms/Details (Date)


Advancis
Pharmaceutical
Corp.
(AVNC)

Stada Arzneimittel AG (Germany)

Stada will supply Amoxicillin Pulsys products for Advancis

Stada subsidiary Clonmel Healthcare Ltd. will provide commercial supplies of the product, which is in Phase III trials for treating infections (4/19)

Affymetrix
Inc.
(AFFX)

CapitalBio Corp. (China)

Deal to develop an advanced GeneChip-compatible personal scanner and a service provider program

CapitalBio will offer the full line of Affymetrix GeneChip products under the deal; they intend to collaborate in other areas, as well (4/26)

Alnylam
Pharmaceuticals
Inc.
(ALNY)

Dowpharma (unit of The Dow Chemical Co.)

Deal for the manufacture and supply of Alnylam candidate RNAi therapeutics

Dowpharma will manufacture siRNAs for use in clinical trials in age-related macular degeneration and respiratory syncytial virus infection (3/29)

Ambion Inc.*

Wyeth

Deal to continue alliance for development and supply of cGMP-grade RNA that will be incorporated in Wyeth's vaccine program

Ambion division Ambion Diagnostics will manufacture RNA transcripts and supply the material for Phase I/II trials (3/8)

Antisoma plc
(UK; LSE:ASM)

Raylo Chemicals (Canada)

Deal for the manufacture of Antisoma's AS1411 (formerly AGRO100)

The product is an anticancer aptamer; terms of the deal were not disclosed (3/14)

Arexis AB*
(Sweden)

CMC Biopharmceuticals (Denmark)

Deal for the production of Arexis' recombinant human BSSL product for upcoming clinical trials

The bile salt-stimulated lipase will be tested for cystic fibrosis and preterm infants; terms of the deal were not disclosed (3/7)

Cellegy
Pharmaceuticals
Inc.
(CLGY)

PT Kalbe Farma (Indonesia)

PT Kalbe got rights to distribute Tostrex (testosterone gel) in parts of the Far East

PT Kalbe got exclusive distribution rights in 11 countries, including Indonesia and Thailand; terms of the deal were not disclosed (3/9)

Cytomedix Inc.
(OTC BB:CYME)

KOL Bio-Medical Instruments Inc.

KOL will represent the company in certain East Coast areas

The six-month deal relates to Cytomedix's AutoloGel therapy; the commission-fee deal could be renewed (3/14)

Evolutec
Group plc*
(UK)

Cambrex Bio Science Baltimore Inc.

Cambrex will manufacture Evolutec's rEV131 for Phase III trials and marketing

The product is in Phase II trials in allergic rhinitis and post- operative treatment fol- lowing cataract surgery; terms were not disclosed (2/28)

GeneExcel
Inc.*

ITX International Holdings Inc.

ITX licensed liposome drug delivery technology for entrance into Japan markets

ITX invested $700,000 in GeneExcel's Series A financing; further terms were not disclosed (3/15)

Gilead
Sciences Inc.
(GILD)

Aspen Pharmacare (South Africa)

Aspen will manufacture and distribute Gilead's HIV products Truvada and Viread in Africa

The nonexclusive deal includes the 95 resource-limited countries in Gilead's global access program; Aspen also will be responsible for regulatory approvals (4/25)

Large Scale
Biology Corp.
(LSBC)

EMD Biosciences Inc. (unit of Merck KGaA)

LSBC will manufacture and supply one of its protein products for distribution by EMD

Terms of the multiyear agreement were not disclosed (4/28)

OpGen Inc.*

M&S
Instruments Inc.
(Japan)

M&S got exclusive distribution rights to OpGen products in Japan

M&S will provide researchers access to Optical Mapping, OpGen's whole-genome analysis system, under undisclosed terms (4/28)

Proteome
Systems
(Australia;
ASX:PXL)

Agilent Technologies Inc.

Collaboration to develop an integrated solution for the analysis of glycoproteins

Proteome will make its GlycomIQ software platform compatible with Agilent's ion trap mass spectrometers (4/18)

Salix
Pharmaceuticals
Ltd.
(SLXP)

Altana Pharma U.S. Inc.

Altana will co-promote Salix's Xifaxan (rifaximin)

Altana will promote the product for travelers' diarrhea to the primary care physician market; terms were not disclosed (3/3)

Spectrum
Pharmaceuticals
Inc.
(SPPI)

Cura Pharmaceuticals Co. Inc.

Deal under which Cura would market Spectrum's carboplatin injection product

Spectrum expects approval of the generic cancer product by mid-2005; terms of the deal were not disclosed (4/14)

WITA GmbH*
(Germany)

SC Biosciences Corp. (Japan)

SCBC will distribute WITA's proteomics technologies in Japan

Terms of the deal were not disclosed (4/27)


Notes:

# The information in the chart does not cover agricultural agreements or those between biotech companies.

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

ASX = Australian Stock Exchange; LSE = London Stock Exchange; OTC BB = Over-the-Counter Bulletin Board.