Biotech Co.*
(Country;
Symbol)

Pharma Co. (Country)

Product

Terms/Details (Date)


Adolor Corp.
(ADLR)

GlaxoSmithKline plc (UK)

Adolor will co-promote GSK's anti-thrombotic agent Arixtra in the U.S.

Adolor is hiring a 30-person sales force and will receive undisclosed cost reimbursement for its promotional efforts (1/3)

Anika
Therapeutics
Inc.
(ANIK)

Bausch & Lomb Inc.

Multiyear supply agreement for viscoelastic products used in ophthalmic surgery

The deal extends a long-term relationship between the companies; terms were not disclosed (12/20)

Biosignal Ltd.
(Australia;
ASX:BOS)

Dr. Reddy's Laboratories (India)

Reddy's Laboratories will develop a large-scale manufacturing procedure for Biosignal compounds

The compounds are antibacterial furanones; terms of the deal were not disclosed (1/20)

Cell
Therapeutics
Inc.
(CTIC)

Quintiles Transnational Corp.

Six-year financing and services deal involving CTI's cancer therapy, Trisenox

CTI gets $25M in cash and $5M in clinical services in exchange for royalties on sales in the U.S. and parts of Europe, which were projected to total at least $53M (12/21)

Chromos
Molecular
Systems Inc.
(Canada; TSE:CHR)

AppTec Laboratory Services Inc.

Alliance to provide a range of cell line engineering and contract manufacturing services

They will coordinate marketing efforts under a nonexclusive arrangement; termswere not disclosed (2/16)

Debiopharm
SA*
(Switzerland)
Transnational Corp.)

Rowfarma S. de RL de CV (unit of Quintiles

Rowfarma will exclusively distribute Decapeptyl in Mexico

Debiopharm will supply the luteinizing hormone releasing hormone, and get royalties on sales (12/20)

DOR
BioPharma
Inc.
(AMEX:DOR)

Cambrex Corp.

Deal for process development and potential large-scale production of DOR's RiVax ricin vaccine

Cambrex will provide process development and cGMP production services for RiVax; terms were not disclosed (1/7)

Flamel
Technologies
Inc.
(France; FLML)

GlaxoSmithKline plc (UK)

Flamel will supply GSK with commercial supplies of Flamel's Micropump formu-lation of an existing GSK drug

GSK licensed the technology for the drug in March 2003; terms were not disclosed (12/21)

Gen-Probe
Inc.
(GPRO)

F. Hoffmann-La Roche Ltd. (Switzerland)

Gen-Probe will purchase products for use in molecular diagnostic assays for human papillomavirus

Roche will manufacture DNA probes for HPV, which Gen-Probe will purchase at agreed-upon transfer prices (2/15)

Helix
BioMedix Inc.
(OTC BB:HXBM)

American Global Health Group LLC

Deal for inclusion of Helix peptide technology in AGHG skin care products

The products are being developed for the Asian market; Helix is entitled to royalties on any resulting sales (2/22)

ICOS Corp.
(ICOS)

Solvay Pharmaceuticals Inc.

Co-promotion agreement for AndroGel (testosterone gel), which is approved in the U.S.

ICOS will provide promotional support through physician details and other activities, and be paid a fee per detail, as well as fees based on specified sales goals (1/31)

Isis
Pharmaceuticals
Inc.
(ISIS)

Drug Royalty USA Inc.

Isis sold a portion of its royalty rights in the approved ophthalmic product Macugen royalties on the first $500M of annual sales, 50% of royalties on sales between $500M

Isis will be paid $24M over three years; through 2009, Drug Royalty gets will get and $1B, and 10% on sales in excess of $1B (12/21)

Nymox
Pharmaceutical
Corp.
(NYMX)

Alifax SpA (Italy)

Deal for the marketing and sales of Nymox's AlzheimAlert product in Italy

Alifax will distribute the Alzheimer's disease diagnostic in Italy under undisclosed terms (2/16)

Pharming
Group NV
(the Netherlands;
Euronext:PHARM)

Diosynth BV (the Netherlands; unit of Akzo Nobel)

Supply agreement for the production of Pharming's recombinant human C1 inhibitor

The product is being developed for hereditary angioedema; terms of the deal were not disclosed (2/8)

ProMetic Life Sciences
Inc.
(Canada;
TSE:PLI)

BioMena SA (Tunisia)

BioMensa licensed ProMetic's Enabling Technology for use in manufacturing drugs for Middle East, North African and certain European markets

ProMetic gets $2.5M up front and $2.5M over two years as a license fee; it also would get royalties on any sales (12/16)

Qiagen NV
(the Netherlands;
QGEN)

Roche Molecular Systems

Roche will market Qiagen's media sample preparation kits under its AmpliLute trademark

Terms of the deal were not disclosed (2/9)

Repligen
Corp.
(RGEN)

GE Healthcare

They amended 1999 supply agreement covering the manufacture of GE's recombinant Protein A

The agreement was extended through 2010, and expanded to include an additional GE protein (2/8)

Savient
Pharmaceuticals
Inc.
(SVNT)

O.R.C.A.Pharm GmbH (Germany)

Deal under which O.R.C.A. will market Soltamox (tamoxifen oral liquid solution) in Germany

Savient subsidiary Rosemont Pharmaceuticals will manufacture the product and get payments based on sales (1/6)


Notes:

# The information in the chart does not cover agricultural agreements or those between biotech companies.

* Private companies are indicated with an asterisk.

Unless otherwise noted, stock symbols listed are on the Nasdaq market.

AMEX = American Stock Exchange; ASX = Australian Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; TSE = Toronto Stock Exchange.