I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $167.735M

Company

Location

Date

Amt. (M)

Details


Altea
Therapeutics

Atlanta

11/22

$17

Altea raised $17M in a Series B round of financing led by Domain Associates and Venrock Associates; vSpring Capital also participated

Athelas Ltd.

Geneva

11/21

CHF2
(US
$1.36)

Athelas secured US$1.36M in a first round of financing led by Arvasis; Novartis Venture Fund and Venture Incubator also invested

Avidis

Clermont-
Ferrand,
France

11/6**

€1.7
(US
$1.7)

Avidis closed its first funding round, raising US$1.7M

BioForce Nanosciences Inc.

Ames, Iowa

11/11

$2

BioForce raised $2M in its first round from the Societe Generale Asset Management in Paris

BioTrove Inc.

Cambridge,
Mass.

11/6

$5.25

BioTrove raised $5.25M in a second round of private financing from a syndicate of new investors; the round was led by Catalyst Health and Technology Partners and includes investments from CB Health Ventures, Zero Stage Capital and BioFrontier Partners

Copernicus Therapeutics Inc.

Cleveland

11/19

$2

Copernicus completed a first close of $2M toward a private financing round of $2.5M

Direvo Biotech
AG

Cologne,
Germany

11/26

€10.5
(US
$10.4)

Direvo raised US$10.4M in its Series B equity financing round led by Danisco Venture and TVM

Dynogen Pharmaceuticals Inc.

Boston

11/13

$13.25

Dynogen raised $13.25M in its first round of private equity financing led by HealthCare Ventures LLC and Oxford Bioscience Partners; A.M. Pappas & Associates also invested

EGeen International
Corp.

Redwood
City, Calif.

11/18

$4.25

EGeen completed its first venture capital round totaling $4.25M; Draper Fisher Jurvetson ePlanet Ventures led the round with participation from Small Enterprise Assistance Funds and BioBank Technology Ventures

ESBAtech AG

Zurich,
Switzerland

11/21

US$3.3

ESBAtech closed an additional US$3.3M in its second round of financing, bringing the total of the round to US$9.9M; investors were Innoventure Capital AG and Venture Incubator AG

GeneCraft Inc.

Seattle

11/25

$13.6

GeneCraft raised $13.6M in its first round of venture financing; investors were Frazier Healthcare Ventures, ARCH Venture Partners, Oxford Bioscience Partners, Cascade Investments, the investment vehicle of Bill Gates, and ATP Capital

MAT Biotech

Evry, France

11/27**

€1.25
(US
$1.25)

MAT Biotech raised US$1.25M from a financing with iXCore, the investment vehicle of an anonymous French business angel

Medisyn Technologies Inc.

Minneapolis

11/26

$1.6

Medisyn completed a $1.6M financing led by Sherpa Partners, with StarTec Investments also participating

Morewood Molecular
Sciences Inc.

Pittsburgh

11/19

$0.55

Morewood raised $550,000 with a new round of angel funding

Nanosphere
Inc.

Northbrook,
Ill.

11/22

$10

Nanosphere raised $10M in its third round of financing led by Lurie Investments and Takara Bio Inc.

Novacea Inc.

South San
Francisco

11/4

$36

Novacea raised $36M in a Series B round led by New Enterprise Associates and Versant; other investors were Domain Associates, ProQuest Investments and Sofinnova Ventures

ObeTherapy Biotechnology

Evry, France

11/27**

€0.325
(US
$0.325)

ObeTherapy raised US$325,000 from iXCore, the investment company of an anonymous French business angel

Psychiatric
Genomics Inc.

Gaithersburg,
Md.

11/19

$17

Psychiatric Genomics raised $17M in the initial tranche of its Series B financing round led by Catalytix LDC; other investors were Oxford Bioscience Partners, GIMV NV, Emerging Technology Partners, CIBC, the Maryland Department of Business and Economic Development, Alexandria Real Estate Equities LP and an unnamed private investor

Surface
Logix
Inc.

Boston

11/26

$25

Surface Logix raised $25M in a Series C round led by HBM BioVentures; other investors were the California Public Employees' Retirement System, Intel Capital, TIAA-CREF, Arch Venture Partners, CW Group and Venrock Associates

Xcellsyz Ltd.

London

11/15

$1.9

Xcellsyz completed a $1.9M equity investment by Northern Enterprises Ltd. and ITX Corp.

II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM EXISTING CORPORATE PARTNERS: $7.05M

Company
(Symbol)#*

Partner
(Country)

Amt.
(M)

Triggering
Event

Details (Date)


ActivX
Biosciences
Inc.*

Kyorin Pharmaceutical Co. Ltd. (Japan)

ND

Investment

Kyorin made an equity investment in ActivX as part of a collaboration to identify and optimize drug candidates to treat Type II diabetes (11/19)

BioSante Pharmaceuticals Inc. (OTC
BB:BISP)

Solvay Pharmaceuticals
BV (Belgium)

$0.95

Milestone payment

BioSante received a $950,000 clinical mile- stone payment related to a license of BioSante's Bio-E/P-Gel topical hormone therapy (11/14)

Cell Therapeutics
Inc.
(CTIC)

Chugai Pharmaceutical Co. Ltd. (Japan)

$3

Milestone payment

Cell Therapeutics earned a $3M milestone payment in connection with the acceptance by regulatory authorities of an investigational new drug application to initiate trials of Xyotax in Japan (11/13)

Connetics
Corp.
(CNCT)

Pharmacia
Corp.

ND

Milestone payment

Connetics received the final milestone payment after the successful completion of a pre-determined milestone with minoxidil foam (11/21)

Evotec OAI AG
(Germany; Neuer
Markt:EVT)

Altana Pharma
AG (Germany)

ND

Milestone payment

Evotec completed its assay development program with Altana, triggering the second milestone payment of the partnership (11/6**)

Iclectus Ltd.*
(UK)

BTG plc

ND

Investment

BTG invested in Iclectus, which focuses on developing intrabody and masked antisense molecules to treat cancer (11/5)

Ligand Pharmaceuticals
Inc.
(LGND)

Eli Lilly
and Co.

$2.1

Milestone payment

Ligand earned the $2.1M payment after Lilly's investigational new drug application for LY674 cleared its FDA waiting period, paving the way for Phase I studies (11/25)

MorphoSys AG
(Germany; Neuer Markt:MOR)

Centocor Inc.
(a Johnson & Johnson company)

ND

Milestone payment

MorphoSys received a milestone payment for successfully installing its fully automated antibody generation system, AutoCAL, at Centocor (11/11)

NeoRx Corp.
(NERX)

Angiotech Pharmaceuticals Inc. (Canada; ANPI; TSE:ANP)

$1

Milestone payment

NeoRx received the $1M milestone payment under an agreement that gives Angiotech an exclusive license, with a right to sublicense, to certain NeoRx U.S. patents and patent applications to use paclitaxel and related compounds to treat vascular diseases and conditions, including restenosis (11/22)

Tularik Inc.
(TLRK)

Eli Lilly and Co.

ND

Milestone payment

Tularik earned a milestone payment from Eli Lilly, which began clinical development of an orally available Factor Xa inhibitor to prevent and treat thrombotic diseases (11/12)


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Denotes privately held company.

** Denotes the date the item ran in BioWorld International.

ND = Not disclosed; OTC BB = Over-the-Counter Bulletin Board; TSE = Toronto Stock Exchange