November 29 (EP), November 23 (WO)
Adv. Tissue Sciences WO 00/69449
Wound healing acceleration.
La Jolla, Calif.
Conditioned cell culture medium; for addition to surgical glue to accelerate wound healing.
Affibody Technol. WO 00/69888
Self-assembling biostructures
Stockholm, Sweden
Self-assembling biomolecular structures having affinity modules, production methods.
Alabama, Univ. of WO 00/69268
Human organ production
Birmingham, Ala.
Production of human cells, tissues, and organs in other animals; for transplantation therapy.
Alabama, Univ. of WO 00/69450
Oncogene identification
Birmingham, Ala.
Identifying oncogenes and their modulators by transforming RK3E cells.
Alabama, Univ. of WO 00/69461
Autoimmunity vaccine
Birmingham, Ala.
Immunization with monoclonal antibodies that are idiotypic for T cell receptors involved in autoimmune disease.
Arbor Vita WO 00/69896
Hematopoietic cell interaction modulation
Sunnyvale, Calif.
Modulation of interactions between proteins in hematopoietic cells and other cells involved in the immune response.
Arbor Vita WO 00/69897
T cell interaction modulation
Sunnyvale, Calif.
Modulation of interactions between proteins in T cells and other cells involved in the immune response.
Arbor Vita WO 00/69898
Allergy cell interaction modulation
Sunnyvale, Calif.
Modulation of interactions between proteins in allergy cells and other cells involved in the immune response.
Aventis Pharma WO 00/70097
Nucleic acid profile searching
Bridgewater, N.J.
Profile searching of nucleic acid sequences using fast Fourier transformation; for finding uncharacterized ESTs.
Aventis Pharma WO 00/70098
Microarray subtractive hybridization
Bridgewater, N.J.
High-throughput microarray-based subtractive hybridization; for finding uncharacterized genes
Avi Biopharma WO 00/69915
Cancer immunotherapy
Corvallis, Ore.
Cancer immunotherapy using monoclonal antibodies to human chorionic gonadotropin.
Bayer EP 1 055 733
Staphylococcus antibacterial screens
Leverkusen, Germany
Staphylococcus fmhB gene, encoded protein, recombinant production methods; for antibacterial screens.
Beijing Med. Univ. WO 00/69910
Chemokine-like factors
Beijing
Chemokine-like factors having cell chemokinesis and proliferation stimulating activity, encoded genes.
Biopharm WO 00/70051
Glial-derived factor-15
Heidelberg, Germany
Glial-derived factor-15, encoding gene, antibodies; for neurodegenerative disease therapeutics.
BioResearch Ireland WO 00/70086
Identifying microorganisms
Dublin, Ireland
Use of the ssrA gene and probes of the gene to identify non-viral organisms in biological samples.
Boehringer Ingelheim EP 1 055 366
Transgenic leukemia model
Ingelheim, Germany
Use of transgenics lacking JunB expression in myeloid lineage cells as a model for chronic myeloid leukemia.
California, Univ. of WO 00/69457
Protein A variants
La Jolla, Calif.
Staphylococcal protein A binding domain variants that still bind to immunoglobulins.
Cedars-Sinai Med. Ctr. WO 00/69257
Male germ cell modification
Los Angeles
Genetic modification of male germ cells; for generating transgenic animals.
Cedars-Sinai Med. Ctr. WO 00/69881
Estrogen response element ligands
Los Angeles
Estrogen response element binding proteins, encoding gene sequences, antibodies, transgenics; for therapeutics.
Chemo-Serotherapeutic Res. Inst. EP 1 055 429
Modified enterotoxin B
Kumamoto, Japan
Modified Staphylococcal enterotoxin B; for inhibiting T cell activation.
Chiron WO 00/70092
Metastatic cancer assay
Emeryville, Calif.
Detection of metastatic cancer cells by measuring gland-specific Ets transcription factor expression.
City of Hope WO 00/70022
Hematopoietic stem cell expansion
Duarte, Calif.
Ex vivo expansion of mammalian hematopoietic stem cells using a stem cell promoting factor.
Columbia Univ. WO 00/70322
CDR-neuregulin assay
New York
Assay for the A-form of CDR-neuregulin; for determining the likelihood of developing cancer.
Conjuchem WO 00/69900
Protection from peptidases
Montreal
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components.
Conjuchem WO 00/69902
Stabilized antiviral peptides
Pasadena, Calif.
Peptides with antiviral and antifusogenic activity that are modified to have greater stability and longer half-lives.
Conjuchem WO 00/69911
Stabilized insulinotropic peptides
Montreal
Modified insulinotropic peptides with greater stability that are conjugated to blood components; for diabetes therapy.
Conjuchem WO 00/70665
Stabilized antiangiogenic peptides
Montreal
Modified antiangiogenic peptides having greater resistance to peptidases; for therapeutics.
CuraGen WO 00/70046
SECX polypeptides
New Haven, Conn.
SECX polypeptides, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Dade Behring WO 00/70095
Isothermal amplification
Deerfield, Ill.
Homogeneous isothermal amplification and detection of nucleic acids using template switch oligonucleotides.
DNAVec Res. WO 00/70055
Gene transfer vehicle
Ibaraki, Japan
RNP with Sendai virus single-stranded RNA that does not express envelope protein; for inserting heterologous genes.
DNAVec Res. WO 00/70070
Paramyxoviridae virus vectors
Ibaraki, Japan
Paramyxoviridae virus vector having a defective envelope gene; for gene transfer and gene therapy.
Dyax WO 00/70023
Fab fragment libraries
Cambridge, Mass.
Fab fragment libraries having 1010 different members; for isolating polyclonal and monoclonal antibodies.
Exact Labs WO 00/70096
Colorectal cancer detection
Maynard, Mass.
Markers indicative of colorectal disease and cancer; for disease screening.
Exponential Biotherapeutics WO 00/69269
Bacterial infection therapy
Washington, N.Y.
Bacteriophage strains that kill vancomycin-resistant Enterococcus faecium; for treating bacteremias.
Genentech WO 00/69460
ErbB2 antibody treatment
S. San Francisco
Methods for treating cancer patients with anti-ErbB2 antibodies.
Genentech WO 00/70050
Immune-related disease proteins
S. San Francisco
Proteins involved in immune-related diseases, encoding gene sequences; for diagnostics and therapeutics.
Genesis Res. & Develop. WO 00/69884
Skin-expressed genes
Auckland, New Zealand
Gene expressed in mammalian skin cells, encoded proteins; for diagnostics and therapeutics.
Genzyme Transgenics WO 00/69256
Mutated antithrombin III
Framingham, Mass.
Transgenics that produce mutated antithrombin III having enhanced antiangiogenic activity.
Henry Ford Hlth. System WO 00/69448
Bone marrow for strokes
Detroit
Transplanting cultured bone marrow cells into the spinal chord or brain; for treating stroke and neurodegeneration.
Human Genome Sciences WO 00/70042
143 secreted proteins
Rockville, Md.
143 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Human Genome Sciences WO 00/70076
Human TM4SF gene
Rockville, Md.
Human TM4SF polypeptides, encoding genes, recombinant production methods, antibodies; for therapeutics.
Incyte Genomics WO 00/70036
Hippocampus-expressed genes
Palo Alto, Calif.
Developmentally-regulated hippocampus-expressed genes, encoded proteins, antibodies; for therapeutics.
Incyte Genomics WO 00/70047
Full-length proteins
Palo Alto, Calif.
Full-length proteins expressed in human tissues, encoding gene sequences, antibodies, modulators; for therapeutics.
Incyte Genomics WO 00/70049
Extracellular signalling proteins
Palo Alto, Calif.
Extracellular signalling proteins, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
INRA (Natl. Inst. Agron. Res.) WO 00/70015
Heterologous protein production
Paris
Selection of insect cells that grow at mammalian-like temperatures; for producing heterologous proteins.
Introgene WO 00/70071
Adenovirus-based gene delivery
Leiden, Netherlands
Adenovirus-derived gene delivery vehicle having inserted adenovirus type 35 genes.
Iowa, Univ. of WO 00/70060
Mammalian polysaccharides
Iowa City, Iowa
Production of complex carbohydrates in bacteria; for making mammalian oligosaccharides and polysaccharides.
Isis Innovation WO 00/69908
Tumor suppressor modulators
Oxford, U.K.
Measuring the interaction between VHL tumor suppressor and hypoxia inducible factor a; for finding modulators.
Isis Pharma WO 00/70091
Protein kinase C antisense
Carlsbad, Calif.
Antisense modulation of human protein kinase C-gamma expression; for treating associated diseases.
Itoh, K. EP 1 055 684
Tumor antigen peptides
Saga, Japan
Tumor antigen peptide derivatives that bind HLA-A24 antigen and are subsequently recognized by cytotoxic T cells.
Japan Sci. & Technol. WO 00/70035
Integrase inhibitor assay
Saitama, Japan
Identifying retroviral integrase inhibitors that target the N-terminal region by using a phage display library assay.
Johns Hopkins Univ. WO 00/70044
Calcium channel splice variants
Baltimore
Human brain T calcium channel a-subunit splice variants; for neural disease diagnostics and therapeutics.
Johns Hopkins Univ. WO 00/70089
Tumor suppressor modulators
Baltimore
Use of human CDX2 as a downstream effector of the tumor suppressor APC; for finding modulators.
Johnson & Johnson WO 00/70028
Sphingosine kinase
Everleigh, Australia
Human sphingosine kinase, derivatives, analogs, encoding gene sequences; for diagnostics and therapeutics.
Karolinska Innovations WO 00/70340
Gene expression comparisons
Stockholm, Sweden
Comparing gene expression patterns at the protein or nucleic acid levels; for disease diagnosis.
Kinetix Pharma WO 00/70030
Lymphocyte kinase modulators
Medford, Mass.
Crystals of a lymphocyte kinase-ligand complex; for identifying modulators.
Lexigen Pharma WO 00/69913
Hepatitis IFN-a fusions
Lexington, Mass.
Expression and export of interferon-a proteins as Fc fusion proteins, encoding gene sequences; for treating hepatitis.
McGill Univ. WO 00/70039
Modifying mRNA populations
Montreal
Methods for subtracting cDNAs by suppressing the synthesis of specifically targeted mRNAs; for modifying mRNA populations.
McGill Univ. WO 00/70351
Protein-protein interactions
Montreal
Methods for identifying interacting proteins and determining the amino acid sequence at the point of interaction.
MRC (Med. Res. Counc.) WO 00/69886
Oligomeric chaperone proteins
London
Oligomeric chaperone proteins; for insertion into a protein scaffold in order to potentiate protein folding.
MRC (Med. Res. Counc.) WO 00/69907
Oligomeric polypeptides
London
Polypeptide monomers that can oligomerize; for insertion into protein scaffolds.
MRC (Med. Res. Counc.) WO 00/70045
OX2 receptor homologs
London
OX2 receptor homologs, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Millennium Pharma WO 00/69880
IL-9/IL-2 receptor-like proteins
Cambridge, Mass.
IL-9/IL-2 receptor-like proteins, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/69885
Secreted proteins
Cambridge, Mass.
Secreted proteins, encoding gene sequences, antisense, antibodies, transgenics; for diagnostics and therapeutics.
Millennium Pharma WO 00/69912
Sodium channel _-3 subunit
Cambridge, Mass.
Sodium channel _-3 subunit, encoding gene, antisense, antibodies, transgenics; for finding modulators.
Mitokor WO 00/70099
Neurodegenerative disease gene expression
San Diego
Measurement of differential gene expression in specific brain regions in neurodegenerative diseases.
Myriad Genetics WO 00/69879
CA7 CG04 gene
Salt Lake City
CA7 CG04 gene, encoded protein, recombinant production methods; for identifying modulators.
New England Biolabs WO 00/70100
Tethering moieties
Beverly, Mass.
Surface display of selenocysteine-containing peptides; for chemically modifying selected amino acid residues.
Oligos WO 00/70093
Modified oligonucleotides
Wilsonville, Ore.
Arrays with modified oligonucleotides and polynucleotides; for increased acid and nuclease resistance.
Oxford Biomedica WO 00/69914
Epithelial immunotherapy
Oxford, U.K.
Human antibodies to the epithelial glycoprotein antigen-2; for diagnostics and immunotherapy.
Pioneer Hi-Bred WO 00/70059
Antibodies from plants
Des Moines, Iowa
Signal transduction genes; for altering expression in plants to produce antibodies.
Promega WO 00/70040
Nucleic acid isolation
Madison, Wis.
Cell concentration and lysate clearance using paramagnetic beads; for isolating nucleic acids.
Scios WO 00/69262
_-secretase variant
Sunnyvale, Calif.
_-secretase variant; for assays to screen for potential Alzheimer's disease therapeutics.
SmithKline Beecham WO 00/69443
Antibacterial screens
Philadelphia
Bacterial ysxC genes, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/69462
RSV antibodies
Philadelphia
Human monoclonal antibodies that react with an epitope of the fusion protein from respiratory syncytial virus.
SmithKline Beecham WO 00/69873
Antibacterial screens
Philadelphia
Bacterial trmD genes, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/70017
Antibacterial screens
Philadelphia
Bacterial FAB I genes, encoded proteins, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/70025
Staphylococcus antibacterial screens
Philadelphia
Staphylococcus aureus RNase P gene, encoded protein, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 00/70033
Mouse htra2 polypeptides
Philadelphia
Mouse htra2 polypeptides, encoding gene sequences, recombinant production methods; for therapeutics.
SmithKline Beecham WO 00/70048 & 70077
Organic anion transporter
Philadelphia
Mouse organic anion transporters, encoding gene sequences; for identifying modulators and therapeutics.
SmithKline Beecham WO 00/70075
Antibacterial screens
Philadelphia
Bacterial yerS genes, encoded proteins, recombinant production methods; for antibacterial screens.
Southern California, Univ. of WO 00/70090
Methylation pattern assay
Los Angeles
High-throughput assay for determining methylation patterns in genomic DNA.
Texas, Univ. of WO 00/69454
Cancer inhibition
Austin, Texas
Suppression of insulin growth factor binding protein-2 amounts or activity; for inhibiting cancer.
Theragen Molec. Med. WO 00/70085
Cancer therapeutic assay
Berlin
Measurement of radiation- and chemotherapeutic-induced gene expression and mutation patterns; for cancer therapy assays.
Thiel, S., et al. WO 00/70043
Mannan-binding lectin
Risskov, Denmark
Recombinant human mannan-binding lectin; for treating increased susceptibility to infections.
U.S. Army WO 00/69891
Botulinum B toxin inhibitors
Ft. Detrick, Md.
Previns for use as building blocks to make inhibitors of the protease activity of botulinum B and tetanus toxins.
U.S. Veterans Admin. WO 00/69909
EGF-related protein
Washington, D.C.
Isolation and characterization of epidermal growth factor-related protein and its gene; for finding modulators.
Utah, Univ. of WO 00/69391
Antibacterial screens
Salt Lake City
Crystal structure of ribosomal protein L11/GTPase activating region rRNA; for finding modulators to treat infection.
Wisconsin, Univ. of WO 00/70026
Streptoverticillium detection
Madison, Wis.
Streptoverticillium mobaraens transglutaminase, encoding gene sequences, antibodies; for detecting the bacteria.
Xencor WO 00/69901
Insulin-like proteins
Pasadena, Calif.
Proteins having insulin-like activity, encoding nucleic acids; for diabetes treatment.
Yissum Res. & Develop. WO 00/70021
Human embryonic stem cells
Jerusalem
Methods for obtaining human-derived embryoid bodies; for producing human embryonic stem cells.
ZymoGenetics WO 00/70032
Angiotensin-converting enzyme
Seattle
Angiotensin-converting enzyme expressed in the digestive system, encoding gene; for controlling blood pressure.