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COMPLETED MERGERS AND ACQUISITIONS - December 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Asys Hitech GmbH (Austria)

Harvard Bioscience Inc. (HBIO)

12/7

12/7

ND

Harvard Bioscience acquired Asys, which should add about $1.5M to $2M in revenue for the company in 2002

Atlantic Stem Cells Inc.

Anthrogenesis Corp.

12/6

12/6

ND

Anthrogenesis acquired Atlantic Stem Cells for an undisclosed amount

Biosonix Ltd. (Israel)

Neoprobe Corp. (OTC BB:NEOP)

9/7

12/11

$3.4

Neoprobe completed an acquisition of Biosonix issuing about 9.7M shares of stock for all of Biosonix's outstanding shares

Cartesian Technologies Inc.

Genomic Solutions Inc. (GNSL)

9/7

12/20

$16

Genomic Solutions issued 6.8M shares of common stock and spent $2.5M in cash to acquire Cartesian

Corporate Technology Development Inc.

Endorex Corp. (AMEX:DOR)

8/1

12/3

$7.7

Endorex issued about 9.4M shares to acquire CTD, a value of $7.7M based on the Dec. 2 stock price

Group Lafon (France)

Cephalon Inc. (CEPH)

12/3

12/3

$450

Cephalon bought the French pharmaceutical company for $450M in cash

Lifecodes Corp.

Orchid Biosciences Inc. (ORCH)

10/1

12/6

$12.7

Orchid acquired Lifecodes for $12.7M in a stock-for-stock transaction under which Lifecodes shareholders received about 6.6M shares

The Intergen Co.

Serologicals Corp. (SERO)

11/6

12/14

$45

Serologicals acquired The Intergen Co. for $45M in cash, less the amount necessary to complete the expansion of Intergen's Toronto manufacturing facility

COMPLETED MERGERS AND ACQUISITIONS - November 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Astralis LLC

Hercules Development Group (OTC BB:HDVG)

9/28

11/14

ND

Astralis and Hercules closed their definitive merger agreement with Hercules issuing about 28M shares of stock

Axys Pharmaceuticals Inc. (AXPH)

Celera Genomics Group (NYSE:CRA)

6/13

11/16

$173.4

Celera acquired Axys by issuing Celera stock equivalent to $4.65 per Axys share; the value of the deal is based on Axys' 37.3M shares outstanding

Hesed Biomed Inc.

Abgenix Inc. (ABGX)

11/14

11/14

$15.9

Abgenix acquired Hesed by issuing about 540,000 shares of common stock valued at about $25 each and paying about $360,000 in cash in exchange for all of Hesed's shares; Abgenix also assumed about $2M in Hesed's debt

NZ Corp.

Lipid Sciences Inc.

11/30

11/30

ND

The companies merged; the merged company will be called Lipid Sciences Inc. and will trade on Nasdaq under the symbol LIPD

Vaxis Therapeutics Corp. (Canada)

Cellegy Pharmaceuticals Inc. (CLGY)

11/29

11/29

$4

Cellegy acquired Vaxis for less than $4M payable primarily in Cellegy stock plus potential earnout payments over a seven-year period

Vysis Inc. (VYSI)

Abbott Laboratories Inc.

10/24

11/30

$355

Abbott acquired Vysis for a cash tender offer of 10.1M shares of Vysis common stock

COMPLETED MERGERS AND ACQUISITIONS - October 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

BioNative AB (Sweden)

Viragen Inc. (AMEX:VRA) and Viragen (Europe) Ltd. (OTC BB:VERP)

7/12

10/1

$2.5

Viragen's subsidiary, Viragen Europe, acquired BioNative for 2.9M shares, valued at about $2.5M; BioNative will be called ViraNative

CCEL Bio-Therapies (subsidiary of Cryo-Cell International Inc.; CCEL)

Saneron Therapeutics Inc.

10/12

10/12

ND

CCEL and Saneron merged; Cryo-Cell will own about 43% of the merged company

ESC Merger Sub Inc. (subsidiary of Ergo Science Corp.)

Ergo Science Corp. (OTC BB:ERGG before Nov. 5; OTC BB:ERGO after Nov. 5)

10/19

10/19

ND

Ergo Science merged with its wholly-owned subsidiary; the merged company will be called Ergo Science Corp.

Lifecodes Corp.

Orchid BioSciences Inc. (ORCH)

10/2

10/2

$12.7

Orchid acquired Lifecodes by issuing about 6.5M shares in return for all of Lifecodes' outstanding shares; the deal was valued at about $12.7M

The Althexis Company Inc.

Microcide Pharmaceuticals Inc. (MCDE)

7/30

10/25

$22.22

Microcide acquired The Althexis Company in a stock swap worth about $22M; Microcide issued about 5.3M shares of stock for all outstanding shares of Althexis; the new company is called Essential Therapeutics Inc. (ETRX)

Viral Genetics Inc.

5 Starliving Online Inc. (OTC BB:HTHV)

9/19

10/3

$44

5 Starliving acquired Viral for 29.7M shares, valuing the deal at about $44M

COMPLETED MERGERS AND ACQUISITIONS - September 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Astralis LLC

Hercules Development Corp.

9/28

9/28

$110.6

Hercules acquired Astralis with 28M shares of new stock; the deal is worth $110.6M

Calydon Inc.

Cell Genesys Inc. (CEGE)

8/1

9/5

$17.4

Cell Genesys acquired Calydon in a stock-for-stock transaction involving 935,000 shares of Cell Genesys stock valued at $17.4M; the deal also includes the assumption of up to about $2.6M in Calydon liabilities

Cell Map (unit of GlaxoSmithKline plc; UK)

Cellzome GmbH (Germany)

9/27

9/27

ND

Cellzome acquired Cell Map; GSK will become a minority shareholder in Cellzome; other terms were not disclosed

Gemini Genomics plc (UK; GMNI)

Sequenom Inc. (SQNM)

5/29

9/20

$238

Companies completed their merger in a stock-for-stock exchange valued at $238M; Sequenom issued about 12.9M shares, and assumed all outstanding options and warrants to purchase an aggregate of 1.5M shares of Sequenom

Novazyme Pharmaceuticals Inc.

Genzyme Corp. (GENZ)

8/7

9/27

$137.5

Genzyme acquired Novazyme for $137.5M in stock; stockholders also are eligible to receive two additional stock payments totaling $87.5M, based on U.S. marketing approval of two Novazyme products

COMPLETED MERGERS AND ACQUISITIONS - August 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Arcaris Inc.

Deltagen Inc. (DGEN)

7/26

8/15

$12.5

Deltagen bought Arcaris by issuing 765,000 new shares of stock and by paying $450,000 in cash plus transaction fees and expenses; it also will reserve about 50,000 shares for Arcaris employee options, and will issue an additional 550,000 shares of common stock upon the achievement of certain milestones

Hemoxymed Inc.

Ophidian Pharmaceuticals Inc. (OTC BB:OPHD)

4/17

8/23

ND

Ophidian acquired all of Hemoxymed's outstanding stock in exchange for its issuance of 19M new, unregistered shares

Isolagen Technologies Inc.

American Financial Holding Inc. (OTC BB:ANFC)

8/22

8/22

ND

American Financial acquired Isolagen in a stock-for-stock transaction; American Financial raised more than $2M in an equity private placement of common stock and converted $1.45M principal amount of Isolagen debt and about $625,000 of accrued liabilities to equity

MultiCell Associates Inc.

Exten Industries Inc. (OTC BB:EXTI)

4/2

8/1

ND

Exten completed the acquisition of MultiCell, through a cash and stock transaction

Proligo LLC

Degussa Corp. (subsidiary of Degussa AG; Germany)

8/29

8/31

US$14.3

Degussa acquired Proligo for US$14.3M paid to Gilead Sciences Inc. for its 49% ownership; it also paid $18M to Proligo for expansion purposes

Richcor Resources Ltd. (Canada)

BioxelPharma Inc. (Canada)

8/2

8/1

ND

BioxelPharma merged with Richcor, granting 1,322 common shares of Richcor for each common share of Bioxel

V.I. Technologies Inc.'s plasma operations (VITX)

Ampersand Ventures and other investors

8/14

8/14

$32

Investors acquired the plasma operations; V.I. Technologies will receive $25M in cash, and the rest over the next two years; the new company will be called Precision Pharma Services Inc.

COMPLETED MERGERS AND ACQUISITIONS - July 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Aronex Pharmaceuticals Inc. (ARNX)

Antigenics Inc. (AGEN)

4/24

7/12

$28.6

Antigenics acquired Aronex for 0.0594 shares of Antigenics' stock for each Aronex share

Aurora Biosciences Corp. (ABSC)

Vertex Pharmaceuticals Inc. (VRTX)

4/30

7/18

$592

Vertex acquired Aurora in a $592M stock-for-stock transaction

Avicenna Medica Inc. (Canada)

KS Biomedix Holdings plc (UK; LSE:KSB)

6/27

7/17

46.44 (US$65.4)

KS Biomedix acquired Avicenna for 41.9M in shares and 4.54M in cash

Biotechna U.A.B. (Lithuania)

Sicor Inc. (SCRI)

7/25

7/25

ND

Sicor purchased Biotechna by issuing 1.5M shares of common stock and a warrant to purchase up to 150,000 shares of common stock at an exercise price of $3.50 per share; Sicor will assume about $30M in debt

Cambridge Discovery Chemistry Inc. (unit of Millennium Pharmaceuticals Inc.; MLNM)

Signature BioScience Inc.

7/16

7/16

ND

Signature acquired Cambridge from Millennium for an undisclosed amount

Coelacanth Corp.

Lexicon Genetics Inc. (LEXG)

6/14

7/12

$32

Lexicon completed its merger with Coelacanth, issuing about 2.9M shares of Lexicon common stock

Cerebrotec

ViaCell Inc.

7/25

7/25

ND

ViaCell acquired Cerebrotec, and will form the ViaCell Neuroscience Division

Computer-aided molecular design unit of Protherics plc (UK)

Tularik Inc. (TLRK)

7/12

7/12

ND

Tularik acquired the Protherics unit for an undisclosed amount

DanProcess A/S (subsidiary of Pantax; Denmark)

Amersham Pharmacia Biotech (unit of Nycomed Amersham plc; NYSE:NYE)

7/23

7/23

ND

Amersham said it acquired 100% of DanProcess for an undisclosed amount

Focal Inc. (FOCL)

Genzyme Corp. (GENZ)

4/26

7/2

$15.9

Genzyme completed its acquisition of Focal and incorporated its operations into Genzyme Biosurgery; about 2.1M shares of Genzyme Biosurgery stock were issued in the transaction

Gendaq Ltd. (UK)

Sangamo BioSciences Inc. (SGMO)

6/28

7/6

$40

Sangamo issued about 2.1M shares of common stock to acquire all of Gendaq's outstanding shares, and it will reserve an additional 125,352 shares to assume all of Gendaq's outstanding options

Genetic Models Inc.

Charles River Laboratories International Inc. (NYSE:CRL)

7/3

7/20

$4

Charles River acquired Genetic Models for $4M in cash

International Market Supply Ltd. (UK)

Harvard Bioscience Inc. (HBIO)

7/3

7/3

$1.4

Harvard Bioscience acquired all of the outstanding stock of International Market Supply for $1.4M

Momentum Healthcare Ltd. (UK)

Cellomics Inc.

7/12

7/12

ND

Cellomics acquired Momentum Healthcare for an undisclosed amount

Periodontix Inc.

Demegen Inc. (OTC BB:DBOT)

2/9

7/16

ND

Demegen completed its acquisition of the majority of the assets of Periodontix for an undisclosed amount

Rosetta Inpharmatics Inc. (RSTA)

Merck Co. Inc.

5/11

7/19

$540

Merck acquired Rosetta

Shearwater Corp.

Inhale Therapeutic Systems Inc. (INHL)

5/22

7/2

$164

Inhale acquired Shearwater for $72.5M in cash and 4M shares of newly issued Inhale stock, valuing the transaction at $164M

Unipex (France)

Atrium Biotechnologies Inc. (subsidiary of AEterna Laboratories Inc.; Canada; AELA; TSE:AEL)

7/3

7/3

$20

Atrium acquired Unipex for about $20M

COMPLETED MERGERS AND ACQUISITIONS - June 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Apollo BioPharmaceuticals Inc.

MitoKor

5/9

6/27

ND

MitoKor acquired Apollo for a combination of stock and cash

NeuroGeneration Corp. and NeuroGenomics Corp.

Theratechnologies Inc. (Canada; TSE:TH)

6/21

6/21

C$18 (US$11.83)

Theratechnologies acquired the two California companies for a total consideration of C$18M in shares of its new subsidiary, Celmed BioSciences

COMPLETED MERGERS AND ACQUISITIONS - May 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Annovis Inc.

Transgenomic Inc. (TBIO)

5/1

5/29

$19.4

Transgenomic acquired Annovis for 1.9M Transgenomic shares and $500,000 in cash

BioChem Pharma Inc. (Canada; BCHM)

Shire Pharmaceuticals Group plc (UK; SHPGY)

12/11

5/11

$4B

The companies merged in a deal involving 231.2M new ordinary shares and worth $4B

Cambridge Drug Discovery Ltd.

BioFocus plc

5/23

5/30

27.5 (US$39)

BioFocus purchased Cambridge Drug Discovery for US$39M

Eligix Inc.

BioTransplant Inc. (BTRN)

12/11

5/16

$55

BioTransplant issued 6.6M shares of its common stock to Eligix shareholders, acquiring Eligix for about $55M

HemaSure Inc. (OTC BB:HMSR)

Whatman Bioscience Inc. (subsidiary of Whatman plc; UK; LSE:WHM)

5/30

5/30

$10

HemaSure completed the sale of its assets, except for cash, cash equivalents and marketable securities; consists of a $10M payment and a reimbursement amount that covers net change in cash from the ongoing business operations from Nov. 1, 2000, through the closing date; HemaSure also will get 4 percent royalties up to $12M in sales of filtration products using its technology

Intellivax International Inc. (Canada)

ID Biomedical Corp. (Canada; TSE:IDP)

3/27

5/16

C$20 (US$12.75)

ID Biomedical issued 4M shares to Intellivax shareholders, acquiring the company in a deal worth $12.75M

NuMax Pharmaceuticals Inc.

Biota Holdings Ltd. (Australia; ASX:BTA)

5/21

5/21

$8

Biota acquired NuMax and will spend $8M over two years to fund NuMax's drug discovery programs; it also will issue employee stock; NuMax will become Biota Inc., the U.S.-based division

Sawady Group (Japan)

Qiagen NV (the Netherlands; QGENF)

5/1

5/1

US$18

Qiagen acquired Sawady through the issuance of 854,987 shares of common stock in exchange for all of the outstanding capital stock of Sawady Technology Co. Ltd. and Omgen Co Ltd.; it also gained a majority position in Accord Co. Ltd.

Union Biometrica Inc.

Harvard Bioscience Inc. (HBIO)

5/31

5/31

$75

Harvard Bioscience will issue 659,282 unregistered shares of its stock, 263,202 options to purchase stock and $7.5M in cash for all outstanding Union shares and options

Warner Instruments Corp.

Harvard Bioscience Inc. (HBIO)

5/1

5/1

ND

Harvard Bioscience acquired Warner Instruments

Xenometrix Inc. (OTC BB:XENO)

Discovery Partners International Inc. (DPII)

2/28

5/9

$1.7

Discovery Partners completed its acquisition of Xenometrix for 59 cents per share; with 2.9M shares outstanding, the deal is valued at $1.7M

COMPLETED MERGERS AND ACQUISITIONS - April 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Advanced Biotechnologies Ltd. (UK)

Apogent Technologies Inc. (NYSE:AOT)

4/10

4/10

ND

Apogent acquired Advanced Biotechnologies, which logged sales revenues for 2000 of about $21M

Armstrong Pharmaceuticals (division of Celltech Manufacturing Inc.)

Andrx Corp. (ADRX)

2/12

4/2

$18

Andrx acquired Armstrong for $18M in cash

Lisfarma Importacao, Exportacao e Comercio Ltda. (Brazil)

Genzyme General (division of Genzyme Corp.)

4/2

4/2

$1.1

Genzyme acquired Lisfarma for about $1.1M

Ophidian Pharmaceuticals Inc. (OTC BB:OPHD)

Promega Corp.

9/1

4/17

$1.2

Ophidian sold its assets to Promega; shareholders will receive $961,000 in proceeds; the company will retain the rest to cover liabilities and expenses

ProBio Inc. (Australia)

Pharming Group NV (the Netherlands; EASDAQ:PHAR)

11/28

4/3

US$4

Acquisition is worth at least $4M in milestone payments over the next two years; in addition, Pharming will transfer shares to the former ProBio shareholders at the share price of EUR12.52 (US$11.17)

Soltec Research Pty. Ltd. (division of F.H. Faulding & Co. Ltd.; Australia)

Connetics Corp. (CNCT)

3/21

4/23

$16.2

Connetics acquired Soltec for about US$16.2M in cash

Xenova Group plc (XNVA)

Cantab Pharmaceuticals plc (CNTBY)

2/20

4/9

124 (US$179)

The companies merged in an all-share deal; Cantab investors received 11 new Xenova shares for every seven Cantab shares

COMPLETED MERGERS AND ACQUISITIONS - March 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Canberra Industries (unit of Packard Bioscience Co.; PBSC)

Cogema (France)

11/30

3/1

$170

Packard completed the sale of Canberra to Cogema for $170M

Display Systems Biotech A/S (Denmark)

NeuroSearch A/S (Denmark)

2/21

2/21

DKK29 (US$3.4)

NeuroSearch acquired Display Systems for US$3.4M and will call the new company Azign Bioscience A/S

Myelos Corp.

Bio-Technology General Corp. (BTGC)

2/22

3/20

$35

Bio-Technology acquired Myelos for $35; a future payment of $30M in cash and stock is contingent upon the filing of a new drug application for Prosaptide

NuCycle Therapy Inc.

Integrated Health Technologies Inc. (IHTC)

3/5

3/5

ND

Integrated Health acquired NuCycle Therapy for an undisclosed amount

PanVera Corp.

Aurora Biosciences Corp. (ABSC)

11/17

3/1

$86

Aurora completed its merger with PanVera, agreeing to issue up to 1.9M shares

Sensus Drug Development Corp.

Pharmacia Corp. (NYSE:PHA)

ND

3/7

ND

Pharmacia acquired the rest of Sensus as part of a 1999 agreement in which it first acquired 20% of the company

Trega Biosciences Inc. (TRGA)

LION bioscience AG (Germany; LEON)

12/27

3/15

$12.25

LION issued about 500,000 American depositary shares, making the acquisition worth $12.25M

Virco Group NV (Belgium)

Tibotec Group NV (Belgium)

1/19

3/15

ND

The companies completed their merger; the combined group will be called Tibotec-Virco NV

COMPLETED MERGERS AND ACQUISITIONS - February 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Bunsen Rush Laboratories Inc.

Arena Pharmaceuticals Inc. (ARNA)

12/27

2/20

$15

Arena acquired Bunsen Rush for $15M in an all-cash transaction

Camitro Corp.

ArQule Inc. (ARQL)

1/16

2/1

$95

ArQule acquired Camitro for 3.4M shares or about $95M

Cellmark Diagnostics (subsidiary of AstraZeneca plc)

Orchid BioSciences Inc. (ORCH)

2/13

2/13

ND

Purchase price was not disclosed, but the deal included an equity stake in Orchid for AstraZeneca

Genetic Solutions Pty. Ltd. (Australia)

GenomicFX LP

2/2

2/2

ND

GenomicFX acquired the livestock genomics company Genetic Solutions for an undisclosed amount

Primedica Corp. (unit of Genzyme Transgenics Corp.; GZTC)

Charles River Laboratories International Inc. (NYSE:CRL)

2/7

2/27

$52

Charles River acquired Primedica for $52M - a $26M cash payment, $16.5M in restricted Charles River stock and the assumption of $9.5M in debt

Symphar SA (Switzerland)

Ilex Oncology Inc. (ILXO)

2/14

2/14

$30

Ilex bought out Symphar for $30M in equal amounts of cash and stock

COMPLETED MERGERS AND ACQUISITIONS - January 2001

Company Acquired

Acquired By Or Merged With

Date Announced

Date Completed

Value (M)

Terms/Details

Auxien Corp.

Mycotech Corp.

1/8

1/8

ND

The two companies merged to form Emerald BioAgricuture Corp. focused on the development, manufacture and marketing of natural crop-protection and yield enhancement products

Bradford Particle Design plc (UK)

Inhale Therapeutic Systems Inc. (INHL)

12/21

1/9

$200

Inhale acquired Bradford for $200M; the offer is $180M in newly issued Inhale stock and $20M in cash; the offer involves about 3.7M shares

Chesapeake Biological Laboratories (Canada; CBLI)

Cangene Corp. (Canada; TSE:CNJ)

10/30

1/4

$31.3

Cangene said its tender offer to purchase all of the outstanding shares of Chesapeake expired 1/3; it has tendered more than 6.8M shares, 93% of the company; shareholders who did not tender their shares received $4.60 per share, net to the stockholder in cash

GeneFormatics Inc.

Structure Function Genomics LLC

1/16

1/16

ND

The companies merged; no further details were disclosed

IGT Pharma Inc. (Canada)

Neurotrophic BioScience Inc. (Canada)

10/00

1/8

US$9

IGT issued 10.734M shares to acquire all the outstanding shares of Neurotrophic in a merger of equals; the companies became Prescient NeuroPharma Inc. (CDNX:PRE)

MAII Holdings Inc. (MAII; formerly Medical Alliance Inc.)

ICN Pharmaceuticals Inc. (NYSE:ICN)

1/3

1/3

$14.4

ICN acquired MAII for $14.4M in cash

Molecular Biosystems Inc. (OTC BB:MBIO)

Alliance Pharmaceutical Corp. (ALLP)

10/00

1/3

$6.16

Alliance completed its acquisition of Molecular Biosystems for 770,000 shares

NeuroVir Therapeutics Inc.

MediGene AG (Germany; Neuer Markt:MDG)

11/00

1/17

$77

MediGene acquired NeuroVir in an all-stock deal

New Chemical Entities Inc.

Albany Molecular Research Inc. (AMRI)

12/19

1/25

$22.4

Albany Molecular acquired New Chemical for $22.4M and assumed $600,000 in outstanding debt

Oy Quattrogene Ltd. (Finland)

Eurogene Ltd. (UK)

1/26

1/26

ND

Eurogene acquired Oy in an all-stock transaction; the combined company will be known as Ark Therapeutics Ltd.

Pathology Associates International Corp.

Charles River Laboratories International Inc. (NYSE:CRL)

12/21

1/9

$37

Charles River completed its acquisition of Pathology for $25M in cash and $12M as a convertible note

Permatec Holding AG (Switzerland)

Medi-Ject Corp. (MEDJ)

1/30

1/30

$14

Medi-Ject issued 2.9M shares worth about $14M in exchange for all the outstanding stock of Permatec

Systems Integration Drug Discovery Co. Inc.

Discovery Partners International Inc. (DPII)

12/21

1/01

ND

Discovery Partners purchased Systems Integration


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