Company* (Symbol)

Product

Description

Indication

Status (Date)

CANCER

AEterna Laboratories Inc. (Canada; AELA; TSE:AEL)

Neovastat/AE-941

Shark cartilage extracted with anti-angiogenic and anti-inflammatory properties

Renal cell carcinoma

Phase III trial is under way in the U.S., Canada and Europe (10/16)

Aronex PharmaceuticalsInc. (ARNX)

Atragen

Liposomal formulation of tretinoin (all transretinoic acid)

Acute promyelocytic leukemia

Investigators reported Phase II trial data at the European Society of Medical Oncology meeting; Atragen demonstrated the potential to induce complete remission (10/16)

Biomira Inc. (BIOM;TSE:BRA)

BLP25

Synthetic MUC1 therapeutic vaccine consisting of 25-amino-acid sequence of the MUC1 cancer mucin, encapsulated in liposomes

Non-small-cell lung cancer

Investigators presented Phase I/II data at the Expo 2000 World Exposition showing the vaccine was well tolerated and capable of generating an immune response; trial was held in Canada (10/17)

Cantab Pharmaceuticals plc (UK; LSE:CTB)

DISC-GMCSF

Consists of Cantab's DISC (disabled infectious single cycle) herpes simplex virus, genetically engineered so it can go through only one replication cycle, carrying the granulocyte macrophage-colony stimulating factor gene

Metastatic melanoma

Company began a Phase I trial of the vaccine (10/18**)

Cell TherapeuticsInc. (CTIC)

Trisenox

Arsenic trioxide injection

Acute promyelocytic leukemia

Trisenox has been granted orphan medicinal product status by the European Commision (10/25)

Hemosol Inc. (Canada; TSE:HML)

HML-115

Autologous gamma-delta T-cell infusion

Chronic myeloid leukemia

Company received approval to begin a Phase I study in Canada (10/17)

Ilex Oncology Inc. (ILXO) and Symphar SA (Switzerland)

Apomine

Orally active biophosphonate tetra-ester derivative

Prostate cancer

Companies opened a Phase II trial for patient accrual in Lyon, France (10/23)

Ligand Pharmaceuticals Inc. (LGND)

Panretin 0.1% gel (FDA-approved)

Topical therapy; Aliretinoin

Cutaneous lesions in patients with AIDS-related Kaposi's sarcoma

European Commission granted marketing authorization (10/17)

Oxford BioMedica plc (UK)

TroVax

Vaccine; targeted at tumor-associated antigens

Colorectal cancer

Company received approval in the UK to enter Phase I/II trials at the end of the year (10/16)

Progen Industries Ltd. (Australia; PGLAF)

PI-88

Retailored polysaccharide with a sulfate chain attached

Cancer

Healthy volunteer studies began in England (10/3)

Select Therapeutics Inc. (OTC BB:SLPU)

VeroPulse

Verotoxin formulation

Multiple myeloma

Select's Canadian subsidiary submitted an IND application in Canada to conduct the first clinical trial of VeroPulse for the ex vivo purging of tumor cells from autologous stem cells in patients with multiple myeloma (10/30)

Xenova Group plc (UK; XNVA; LSE:XEN)

XR9576

P-glycoprotein pump inhibitor

Cancer

Company confirmed a positive outcome in the second of three Phase IIa pharmacokinetic trials in which XR9576 was administered in combination with doxorubicin (10/18)

CARDIOVASCULAR

D-Pharm Ltd. (Israel)*

DP-b99

Mechanism of action targets apoptosis

Stroke and traumatic brain injury

Company completed a Phase I safety assessment study and is initiating Phase II studies in Europe (10/16)

Medicure Inc. (CDNX:MPH)

Cardoxal

Oral therapeutic

Myocardial infarction and ischemic reperfusion injury

Canada's Therapeutic Products Directorate approved the company's IND application (10/19); company commenced its first clinical trial (10/25)

Progen Industries Ltd. (Australia; PGLAF)

PI-88

Retailored polysaccharide with a sulfate chain attached

Cardiovascular disease

Healthy volunteer studies began in England (10/3)

ThromboGenics Ltd.*

PEG-Sak

Form of staphylokinase, a thrombolytic protein, and a polyethylene glycol tag

Acute myocardial infarction

Pilot clinical trial results were published in the October issue of Circulation; the trial, held in Belgium, demonstrated that PEG-Sak effectively dissolved heart attack clots when given as a single bolus (10/26)

CENTRAL NERVOUS SYSTEM

Neurocrine Biosciences Inc. (NBIX)

NBI 5788

Altered peptide ligand targeting T cells that bind to myelin sheath

Relapsing-remitting multiple sclerosis

Company's double-blind, randomized, placebo-controlled Phase II data were published in the October edition of Nature Medicine; showed evidence of clinical benefit (10/2)

INFECTION

Avanir Pharmaceuticals (AMEX:AVN)

Abreva (FDA-approved)

Docosanol 10% cream

Cold sores

Company filed a new drug submission with the Canadian Therapeutic Products Programme (10/3)

Aviron (AVIR) and SmithKline Beecham Biologicals (UK; NYSE:SBH)

Investigational vaccine

Vaccine combines EBV vaccine technology with adjuvant technology

Epstein-Barr virus

Company initiated a Phase II randomized, double-blind trial being conducted at two universities in Belgium (10/25)

Chiron Corp. (CHIR)

Menjugate

Conjugate vaccine against Neisseria meningitidis sero group C

Meningococcal disease

The UK's Medicines Control Agency and the Irish Medicines Board approved Menjugate for immunizing infants aged 2 months and older against meningococcal disease caused by Neisseria meningitidis serogroup C (10/17)

Immtech International Inc. (IMMT)

DB289

Oral, anti-infective

Pneumocystis carini pneumonia

Company received approval to begin a Phase I trial in 72 volunteers in Berlin (10/13)

StressGen Biotechnologies (SSB:TSE)

HspE7

Recombinant fusion protein composed of heat shock protein 65 from Mycobacterium bovis BCG and the protein E7 from HPV type 16

Human papilloma-virus-related anal dysplasia

Phase II data confirm activity of HspE7, which converts 75% of patients from high-grade to low-grade anal dysplasia at six months; data were presented at Cancer Vaccines 2000 (10/3)

Vertex Pharmaceuticals Inc. (VRTX) and Glaxo Wellcome plc (UK; NYSE:GLX)

Agenerase

Protease inhibitor

HIV

Vertex and Glaxo received approval from the European Commission to market Agenerase in the European Union in combination with other antiretroviral agents for the treatment of HIV (10/23)

MISCELLANEOUS

Alizyme plc (UK; LSE:AZM)

ATL-1251

5-HT4 receptor agonist/5-HT3 receptor antagonist

Irritable bowel syndrome

Alizyme announced positive results of a Phase IIa trial involving 20 patients tested at centers in the UK and Belgium (10/18**)

Alizyme plc (UK; LSE:AZM)

ATL-962

Lipase inhibitor that prevents the breakdown of fat in the gut

Obesity

Company received approval to start a Phase Ib trial in a specialist center in Germany (10/18**)

Coley Pharmaceutical Group*

CpG compound

Immune modulator designed to redirect hypersensitive immune responses into more normal responses

Asthma/allergy

Company initiated Phase II trials at Southampton General Hospital in the UK; trial is designed to evaluate the safety and efficacy of the CpG product (10/19)

CollaGenex Pharmaceuticals Inc. (CGPI)

Periostat

Doxycyline hyclate 20mg

Adult periodontitis

Company announced Periostat is now available for prescription in the UK (10/5)

Collateral Therapeutics Inc. (CLTX) and Schering AG

Genvascor

Non-surgical angiogenic

Peripheral vascular disease

Schering filed regulatory applications with six European health authorities to begin clinical trials (10/12)

Neurochem Inc. (Canada; TSE;NRM)

Fibrillex

Glycosaminoglycan (GAG) mimetic

Secondary amyloidosis

Company filed for orphan medicinal product designation in Europe (10/31)

Oxford Glyco-Sciences plc (UK; LSE:OGS)

Vevesca (OGT 918)

Oral capsule formulation of a glucosyltransferase inhibitor

Gaucher's disease

Vevesca has been designated as an orphan medicinal product by the European Commission (10/25)

Theratechnologies Inc. (Canada; TSE TH)

ThGRF 1-44

Peptide; a growth hormone-releasing factor analogue

Age-related sleep impairment

Company filed an IND in Canada to begin a Phase II study of two doses of ThGRF 1-44 in healthy subjects (10/17)

Wex Technologies Inc. (CDNX:WXI)

Tetrodin

Non-narcotic analgesic

Opiate addictions

Company filed an IND application in Canada to begin a Phase I trial (10/10)

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