Medical products manufacturer B. Braun Medical (Bethlehem, Pennsylvania) has signed an agreement with Novation (Irving, Texas), the supply company of VHA and the University HealthSystem Consortium (UHC), taking effect on July 1 and running through May 31, 2005. Through the agreement, B. Braun will be one of two companies providing large-volume infusion pumps and needle-free devices to UHC members. Novation represents more than 2,000 health care organizations nationwide, including the member and affiliates of VHA and UHC.

Cytogen (Princeton, New Jersey) and Advanced Magnetics (AM; Cambridge, Massachusetts) said they mutually agreed to end their plan to merge and instead will enter into a marketing, license and supply agreement. Cytogen will acquire certain product rights to Advanced Magnetics' imaging agents in exchange for two million shares of Cytogen stock. Cytogen will have exclusive U.S. rights to AM's Combidex, a magnetic resonance imaging contrast agent for the detection of lymph node metastases and have exclusive U.S. rights to imaging agent Code 7228 for oncology applications, plus the right of first negotiation for applications outside of oncology. AM will pay all costs associated with clinical development, supply and manufacture of Combidex and Code 7228 and will receive product sale royalties. "Both Cytogen and Advanced Magnetics agreed that the advantages of a marketing and supply arrangement outweighed the near-term benefits of the merger," said H. Joseph Reiser, PhD, Cytogen president and CEO. "Our ongoing business relationship with Advanced Magnetics is consistent with our strategic focus to build a product-oriented pipeline in oncology, and to that end we continue to investigate other near-term product opportunities." Jerome Goldstein, chairman and CEO of AM, said the market and supply arrangement had greater "near-term benefits" than a merger. (Seattle, Washington) will be the exclusive online provider of medical, surgical and pharmaceutical supplies, information and other e-commerce solutions for Pacific Health Alliance (Burlingame, California). The company said the agreement will introduce Esurg to more than 40,000 physicians working in a wide range of specialties. Esurg allows practices to create and save personalized lists of products they order on a regular basis, thereby reducing the time it takes to restock supplies. Pacific Health Alliance has contracts with over 300 hospitals and 40,000 physicians, offering a range of services to providers, payers and consumers.

Exactech (Gainesville, Florida), maker of orthopedic joint implants, has signed an agreement with aap Implantate AG (Berlin, Germany) and aap Implants, the company's Massachusetts-based subsidiary, for the exclusive distribution rights to aap Implantate products in the U.S. The aap products to be initially distributed by Exactech are a hip compression screw system, a range of large and small-cannulated screws and the Biorigid Tibial Nail. aap Implantate is focused on the production of endoprosthetic products, which permanently replace damaged joints, and osteosynthesis products, or temporary implants, which help the healing of bone fractures. Exactech makes and markets orthopedic implant devices, related surgical instruments and biologic products.

GE Medical Systems Information Technologies (Milwaukee, Wisconsin) and Masimo (Irvine, California) have signed a licensing agreement allowing GE to offer Masimo's Signal Extraction Technology (SET) pulse oximetry as a platform choice for its line of patient monitoring systems. GE has made a $5 million equity investment in Masimo. Masimo Signal Extraction pulse oximetry is a used to obtain a patient's oxygenation levels and provide health care professionals with a source of information for treatment. An initial agreement between the two companies was signed in June 1999 for inclusion of Masimo SET into the Solar monitor, with the new agreement becoming an expansion of that pact. Masimo makes medical signal processing technologies and products for the noninvasive monitoring of vital signs. GE Medical Systems Information Technologies provides solutions for the acquisition, analysis and management of patient data in health care facilities; its offerings including cardiology, patient monitoring, image management, clinical information systems and performance management services.

iManage (San Mateo, California), a provider of e-business content and collaboration software platforms and applications, and Lanier Worldwide (Atlanta, Georgia) have signed an OEM agreement designed to improve the patient record-management process for more than 250,000 U.S. physicians and provide iManage with a prominent partner for establishing its collaboration products. Lanier's Cquence eSign will enable physicians to electronically sign medical records. It is being developed using the iManage collaborative platform and applications, as well as Microsoft's Internet Information Server and SQL Server. Cquence eSign is expected to be available at the end of the year.

Orthofix International (Richardson, Texas) has signed agreements with Aetna U.S. Healthcare (Hartford, Connecticut) and Empire Blue Cross & Blue Shield (New York) for the two managed care organizations to provide insurance coverage to their combined 19 million members for prescriptions of Orthofix's bone growth stimulator product line.

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