Company

Symbol

12/31/97**

12/31/98

%YTD

Avigen

AVGN

2.25

7.812

247

Liposome Co

LIPO

4.625

15.438

234

Gliatech

GLIA

10.25

30

193

Sequus Pharm

SEQU

7.437

20.25

172

ImmunoGen

IMGN

0.839

2.188

161

Enzon

ENZN

5.5

13.312

142

Flamel Tech

FLMLY

1.812

4.375

141

Immunex

IMNX

54

125.811

133

MedImmune

MEDI

42.875

99.438

132

NeoPharm

NEO

5.25

12.125

131

Igen

IGEN

13.25

30.625

131

Biogen

BGEN

36.375

83

128

Sepracor

SEPR

40.06

87.563

119

Cypress Bio

CYPB

1.437

3

109

QLT PhotoTher

QLTIF

11.125

22.75

104

Theratech

THRT

8

16.25

103

Abgenix

ABGX

8

16.25

103