Company

Symbol

12/31/97**

12/31/98

%YTD

NPS Pharm

NPSP

7.75

7.687

-1

Immune Resp

IMNR

11.125

10.875

-2

Genelabs

GNLB

2.812

2.75

-2

Martek Bio

MATK

8.25

8

-3

Collateral Thera

CLTX

7.25

7

-3

Dianon Systems

DIAN

9.375

9

-4

Lifecell

LIFC

4.625

4.375

-5

Aviron

AVIR

27.125

25.875

-5

Maxim Pharma

MMP

16.375

15.375

-6

Embrex

EMBX

5.312

5

-6

Triangle Pharma

VIRS

14.625

13.625

-7

Draxis Health

DRAXF

3.062

2.858

-7

Celtrix

CTRX

1.812

1.687

-7

Aquila Biopharma

AQLA

4.187

3.875

-7

Neose Technol

NTEC

15.25

14.063

-8

MacroChem

MCHM

9.125

8.436

-8

LeukoSite

LKST

10.935

10.063

-8

Biotime

BTIM

19

17.375

-9

Vertex Pharm

VRTX

33

29.75

-10

Trimeris

TRMS

13

11.75

-10

Onyx Pharma

ONXX

7.75

7

-10

Ligand

LGND

12.875

11.625

-10

ID Biomed

IDB*

3.399

3.07

-10

Human Genome

HGSI

39.75

35.56

-11

Progenics Pharma

PGNX

14

12.375

-12

Neurocrine Biosci

NBIX

7.875

6.875

-13

Gene Logic

GLGC

8

6.969

-13

Ecogen

EECN

1.937

1.687

-13

Teva Pharm

TEVIY

47.31

40.688

-14

Regeneron

REGN

8.56

7.375

-14

GelTex

GELX

26.5

22.625

-15

Emisphere

EMIS

18.625

15.625

-16

Adv Magnetics

AVM

8.75

7.312

-16

Incyte Pharm

INCY

45

37.375

-17

Synbiotics

SBIO

3.125

2.561

-18

Cantab Pharm

CNTBY

11.75

9.625

-18

NeXstar Pharm

NXTR

11.375

9.25

-19

Adv Poly Sys

APOS

6.625

5.375

-19

Texas Biotech

TXB

6.187

4.937

-20

Pharmos

PARS

2

1.592

-20

US Bioscience

UBS

9.06

7.187

-21

NABI

NABI

3.406

2.688

-21

Diatide

DITI

9.125

7.25

-21

Collab. Clin. Res

CCLR

5.062

4

-21

Cephalon

CEPH

11.375

9

-21

Noven

NOVN

7

5.437

-22

Gensia Sicor

GNSA

5.812

4.53

-22

Affymetrix

AFFX

31.125

24.375

-22

Protein Poly

PPTI

1.625

1.25

-23

CollaGenex

CGPI

12.5

9.625

-23

Matrix

MATX

3.437

2.625

-24

Cypros Pharma

CYP

4.25

3.25

-24

Micrologix Biotec

MBI*

3.6

2.7

-25

Viragen

VRGN

1.092

0.813

-26

Calypte Biomed

CALY

3.875

2.875

-26

SIBIA Neurosci

SIBI

6.5

4.75

-27

Corvas

CVAS

3.875

2.812

-27

Transkaryotic

TKTX

35.125

25.375

-28

Epix Medical

EPIX

13

9.313

-28

DNAP Holding

DNAP

4.858

3.5

-28

Avant Immuno

AVAN

2.435

1.75

-28

Lynx Therapeutics

LYNX

16.25

11.5

-29

Guilford Pharm

GLFD

20.125

14.25

-29

Enzo Biochem

ENZ

14.625

10.313

-29

Cell Genesys

CEGE

8.5

6

-29

Palatin Tech

PLTN

5.875

4.125

-30

Axys Pharma

AXPH

8.375

5.875

-30

Parexel Intl

PRXL

37

25

-32

Avax Technologies

AVXT

3.687

2.5

-32

AutoImmune

AIMM

3.312

2.25

-32

Trinity Bio

TRIBY

1.967

1.312

-33

Quidel

QDEL

3.625

2.438

-33

Meridian Diag

KITS

10.125

6.75

-33

Hycor Bio

HYBD

1.562

1.046

-33

Discovery Labs

DSCO

4

2.625

-34

Cubist Pharma

CBST

5.812

3.813

-34

Aastrom Biosci

ASTM

4.375

2.875

-34

ImmuLogic

IMUL

1.875

1.219

-35

DepoTech

DEPO

3.562

2.313

-35

Bio-Tech Gen

BTGC

10.75

6.937

-35

Dusa Pharma

DUSA

11.5

7.375

-36

Digene

DIGE

8.625

5.562

-36

Ribi Immuno

RIBI

3.687

2.313

-37

Biora AB

BIORY

20.75

13

-37

Trega Biosciences

TRGA

3.437

2.125

-38

SuperGen

SUPG

15

9.25

-38

CIMA Labs

CIMA

4.25

2.625

-38

OXiGENE

OXGN

17.5

10.75

-39

Curagen Corp.

CRGN

11.5

7.062

-39

Atrix Labs

ATRX

14.75

8.875

-40

Pharmacopeia

PCOP

16

9.5

-41

Diacrin

DCRN

10.125

5.937

-41

Cor Thera

CORR

22.5

13.25

-41

AVI BioPharma

AVII

6.812

4

-41

Protein Design

PDLI

40

23.25

-42

Medarex

MEDX

5.25

3.031

-42

Genzyme Trans

GZTC

9.625

5.625

-42

XOMA

XOMA

5.562

3.188

-43

Unimed Pharma

UMED

7.562

4.312

-43

CliniChem Devlp

CCHE

8.375

4.812

-43

VimRx

VMRX

1.937

1.094

-44

NaPro Biother

NPRO

2.5

1.406

-44

Ribozyme Pharma

RZYM

8

4.375

-45

Hyseq

HYSQ

9.625

5.25

-45

AMBI Inc.

AMBI

1.937

1.062

-45

CombiChem

CCHM

8

4.312

-46

ViroPharma

VPHM

17.625

9.313

-47

Stressgen Biotech

SSB*

3.092

1.64

-47

LXR Biotech

LXR

2.375

1.25

-47

Tripos

TRPS

14.625

7.625

-48

SangStat Med

SANG

40.5

21.25

-48

Cytogen

CYTO

1.625

0.843

-48

Organogenesis

ORG

21.5

11

-49

Immucell

ICCC

2.467

1.25

-49

CV Therapeutics

CVTX

9.375

4.75

-49

Techniclone Int'l

TCLN

2.185

1.094

-50

Targeted Genet

TGEN

2.625

1.312

-50

Intercardia

ITRC

17.875

9

-50

Creative Bio

CBMI

7.375

3.688

-50

ClinTrials

CCRO

7.875

3.938

-50

Carrington

CARN

4.312

2.125

-51

Aurora Bioscience

ABSC

13.125

6.437

-51

ProCyte

PRCY

0.937

0.438

-53

OSI Pharma

OSIP

6.75

3.188

-53

Lifecore Bio

LCBM

21.875

10.25

-53

GeneMedicine

GMED

5.062

2.375

-53

Aronex Pharma

ARNX

4.25

2

-53

Genz Mol Oncol

GZMO

7

3.25

-54

Vysis

VYSI

12

5.375

-55

Unigene

UGNE

2.625

1.187

-55

LJL Biosystems

LJLB

7

3.125

-55

Alliance

ALLP

7.25

3.281

-55

Microcide Pharma

MCDE

8.875

3.875

-56

Genome Thera

GENE

6.312

2.75

-56

Cortex

CORX

1.5

0.656

-56

BioTransplant

BTRN

5.75

2.5

-57

Cellegy Pharma

CLGY

8.375

3.5

-58

Myriad Genetics

MYGN

24.25

10

-59

Ophidian Pharma

OPHD

4.421

1.75

-60

Magainin

MAGN

8.06

3.187

-60

Ariad Pharm

ARIA

4.25

1.687

-60

Shaman

SHMN

4.937

1.906

-61

RiboGene

RBO

7

2.75

-61

Novavax

NOX

5

1.937

-61

Am Bio Sci

MABXA

1.906

0.75

-61

Integra LifeScien

IART

8.875

3.375

-62

InSite Vision

ISV

3.25

1.25

-62

Endorex

DOR

5.5

2.063

-62

Cyanotech

CYAN

2.781

1.062

-62

CytoTherapeut

CTII

4

1.469

-63

Cambridge Neuro

CNSI

1.967

0.718

-63

North Am Vacc

NVX

24.937

8.875

-64

Nanogen

NGEN

11

4

-64

Megabios

MBIO

14.25

5.125

-64

Allelix

AXB*

11.5

4.19

-64

Molecular Bio

MB

8.5

2.938

-65

Interneuron

IPIC

9.5

3.281

-65

British Biotech

BBIOY

16.625

5.875

-65

Bioreliance

BREL

23

8

-65

Matritech

NMPS

4.875

1.656

-66

Genz Tiss Repair

GENZL

6.875

2.25

-67

Dura Pharm

DURA

45.875

15.188

-67

CytRx

CYTR

2.937

0.968

-67

Siga Pharma

SGPH

4.625

1.437

-69

SciClone

SCLN

3.437

1.062

-69

Cholestech

CTEC

12.5

3.812

-70

Cadus Pharma

KDUS

6.375

1.937

-70

Synsorb Biotech

SYBBF

8.5

2.375

-72

Metra Biosys

MTRA

3.625

1

-72

Avanir Pharma

AVNR

2.375

0.656

-72

Alpha Beta

ABTI

2.592

0.688

-73

Chrysalis Intl

CRLS

2.156

0.562

-74

Cel-Sci

HIV

6.625

1.75

-74

Xenova Group

XNVAY

2.25

0.563

-75

Procept

PRCT

10

2.5

-75

Cygnus

CYGN

19.875

4.875

-75

NeoRx Corp.

NERX

5.625

1.344

-76

Amarillo Biosci

AMAR

5.5

1.25

-77

SunPharm

SUNP

4.5

1

-78

Atlantic Pharma

ATLC

6.75

1.5

-78

ArQule

ARQL

22.937

4.937

-78

Cytel

CYTL

10.5

2.25

-79

Advanced Tissue

ATIS

12.375

2.592

-79

Sonus Pharma

SNUS

33.125

6.75

-80

Columbia Labs

COB

16.25

3.063

-81

Anergen

ANRG

2.125

0.406

-81

Agritope

AGTO

7

1.312

-81

Medical Science

MSSI

5.625

1

-82

Cell Therapeutics

CTIC

17

3

-82

Transcend Thera

TSND

7.5

1.25

-83

Ostex Int'l

OSTX

2.625

0.406

-85

Envirogen

ENVG

9

1.375

-85

AltaRex

AXO*

3

0.46

-85

Neoprobe

NEOP

6

0.718

-88

Alteon

ALTN

7.312

0.781

-89

CoCensys

COCN

3.437

0.313

-91

Amylin

AMLN

5.437

0.5

-91

Ergo Science

ERGO

15.25

1

-93

Cortecs Intl

DLVRY

14.25

0.843

-94

Interferon Sci

IFSC

8.685

0.438

-95