Company

Symbol

12/31/97**

12/31/98

%YTD

Agouron

AGPH

29.375

58.75

100

Pharma Prod Devlp

PPDI

15.375

30.063

96

Biomatrix

BXM

30

58.25

94

Amgen

AMGN

54.125

104.563

93

Connetics Corp.

CNCT

3.062

5.875

92

Icon plc

ICLRY

18

33.5

86

EntreMed

ENMD

11.31

21

86

DepoMed

DMI

4.25

7.875

85

Celgene

CELG

8.435

15.375

82

Genzyme

GENZ

27.75

49.75

79

Sheffield

SHM

1.375

2.375

73

Osteotech

OSTE

27.25

46.5

71

Idexx Labs

IDXX

15.937

26.905

69

Phoenix Intl

PHX*

10.25

17

66

Axogen

AXG.U

39.75

66

66

Repligen

RGEN

0.781

1.28

64

Genta

GNTA

0.781

1.28

64

Alza

AZA

31.812

52.25

64

Genetronics

GEB*

3.092

5.049

63

Anesta

NSTA

16.375

26.625

63

Icos

ICOS

18.312

29.75

62

PathoGenesis

PGNS

37.125

58

56

Chiron

CHIR

17

26.187

54

ILEX Oncology

ILXO

7.375

11.125

51

Coulter Pharma

CLTR

20.25

30

48

Aradigm

ARDM

8.5

12.5

47

Biomira

BIOMF

2.125

3.092

46

Boston Life

BLSI

2.281

3.25

42

Quintiles

QTRN

38.25

53.375

40

Genset

GENXY

19.75

27.625

40

Vion Pharma

VION

3.625

5

38

Synaptic Pharma

SNAP

10.875

15

38

IDEC Pharm

IDPH

34.375

47

37

Elan

ELN

51.185

69.938

37

Biochem Pharma

BCHE

20.875

28.625

37

Oxis Int'l

OXIS

2.108

2.875

36

Northfield Labs

NFLD

9.125

12.375

36

Millennium

MLNM

19

25.875

36

Centocor

CNTO

33.25

45.125

36

Qiagen

QGENF

44.625

60.25

35

Visible Genetics

VGIN

8.56

11.375

33

Cell Pathways

CLPA

16.5

22

33

Geron

GERN

8.25

10.875

32

Genentech

GNE

60.625

79.688

31

Neurogen

NRGN

13.5

17.5

30

Angiotech Pharma

ANP*

10

13

30

Hemosol

HML*

2.188

2.8

28

Inhale Ther Sys

INHL

26

33

27

Aphton

APHT

10.125

12.75

26

InKine Pharma

INKP

1.375

1.687

23

Vical

VICL

12

14.187

18

Epitope

EPTO

5

5.875

18

Crescendo Pharma

CNDO

11.56

13.625

18

Life Tech

LTEK

33.25

38.875

17

GalaGen

GGEN

1.875

2.156

15

Immunomed

IMMU

3.625

4.125

14

Ethical Hldgs

ETHCY

3.125

3.563

14

Sugen

SUGN

13.125

14.75

12

ImClone Sys

IMCL

8.125

9.063

12

Diagnostic Prod

DP

27.75

31.125

12

Alkermes

ALKS

19.875

22.187

12

Gilead Sciences

GILD

38.25

41.063

7

Alexion Pharma

ALXN

12.5

13.375

7

Transgene

TRGNY

14.5

15.375

6

Zonagen

ZONA

18.187

19.125

5

Isis Pharm

ISIP

12.31

12.937

5

Bioject

BJCT

1.28

1.344

5

Scios

SCIO

10

10.375

4

Corixa

CRXA

8.935

9.25

4

UroCor

UCOR

6.187

6.375

3

Molecular Devices

MDCC

21.25

21.75

2

La Jolla Pharm

LJPC

4.437

4.5

1

Immucor

BLUD

8.625

8.75

1

Pharmacyclics

PCYC

25.625

25.5

0

Ortec Int'l

ORTC

13.06

13.125

0

NeoTherapeutics

NEOT

10.5

10.5

0

Cytoclonal Pharma

CYPH

6.875

6.875

0

BioCryst

BCRX

7

7

0