| Company Name | Symbol | 12/31/1999 | 12/31/00 | %YTD |
| Genzyme | GENZ | 45 | 89.938 | 99.86 |
| Siga Technologies | SIGA | 1.625 | 3.156 | 94.22 |
| IDEC Pharm | IDPH | 98.25 | 189.563 | 92.94 |
| LION Biosciences | LEON | 39.68 | 75.375 | 89.96 |
| Tripos | TRPS | 11.5 | 21.75 | 89.13 |
| La Jolla Pharm | LJPC | 2.531 | 4.719 | 86.45 |
| Sicor | SCRI | 7.75 | 14.438 | 86.3 |
| Titan Pharma | TTP | 19 | 35.37 | 86.16 |
| AutoImmune | AIMM | 0.813 | 1.5 | 84.5 |
| Qiagen | QGENF | 18.875 | 34.594 | 83.28 |
| Cephalon | CEPH | 34.563 | 63.313 | 83.18 |
| Human Genome Sci | HGSI | 38.156 | 69.313 | 81.66 |
| InterMune | ITMN | 25 | 44.625 | 78.5 |
| Abgenix | ABGX | 33.125 | 59.063 | 78.3 |
| Cell Genesys | CEGE | 12.813 | 22.813 | 78.05 |
| Icos | ICOS | 29.25 | 51.938 | 77.57 |
| Techniclone Int'l | TCLN | 0.531 | 0.938 | 76.65 |
| NeoPharm | NEOL | 21.563 | 37.875 | 75.65 |
| Immunomedic | IMMU | 12.25 | 21.5 | 75.51 |
| Orchid | ORCH | 8 | 14 | 75 |
| Cellegy Pharma | CLGY | 3.375 | 5.875 | 74.07 |
| StemCells | STEM | 1.469 | 2.5 | 70.18 |
| Isis Pharm | ISIP | 6.25 | 10.625 | 70 |
| Targeted Genet | TGEN | 3.938 | 6.688 | 69.83 |
| Ariad Pharm | ARIA | 2.813 | 4.75 | 68.86 |
| Draxis Health | DRAX | 1.188 | 2 | 68.35 |
| Corixa | CRXA | 17 | 27.875 | 63.97 |
| Sepracor | SEPR | 49.594 | 80.125 | 61.56 |
| Aradigm | ARDM | 9.5 | 14.625 | 53.95 |
| Gilead Sciences | GILD | 54.125 | 82.938 | 53.23 |
| Discovery Labs | DSCO | 2.781 | 4.219 | 51.71 |
| Novavax | NOX | 5.625 | 8.5 | 51.11 |
| Cubist Pharma | CBST | 19.25 | 29 | 50.65 |
| Dendreon | DNDN | 10 | 15 | 50 |
| Onyx Pharma | ONXX | 10 | 14.875 | 48.75 |
| Biochem Pharma | BCHE | 21.75 | 32 | 47.13 |
| Invitrogen | IVGN | 60 | 86.375 | 43.96 |
| Enzon | ENZN | 43.375 | 62.063 | 43.08 |
| Embrex | EMBX | 10.75 | 15.375 | 43.02 |
| Paradigm | PDGM | 7 | 10 | 42.86 |
| Aronex Pharma | ARNX | 3.125 | 4.438 | 42.02 |
| Incara Pharma | INCR | 1.5 | 2.125 | 41.67 |
| Dyax | DYAX | 15 | 21.188 | 41.25 |
| Cepheid | CPHD | 6 | 8.438 | 40.63 |
| Celgene | CELG | 23.33 | 32.5 | 39.31 |
| Genaissance | GNSC | 13 | 18 | 38.46 |
| Axys Pharma | AXPH | 4.063 | 5.625 | 38.44 |
| Tanox | TNOX | 28.5 | 39.188 | 37.5 |
| Biomira | BIOM | 3.938 | 5.375 | 36.49 |
| Idexx Labs | IDXX | 16.125 | 22 | 36.43 |
| Ribozyme | RZYM | 10.5 | 14.313 | 36.31 |
| Palatin Tech | PTN | 2.5 | 3.375 | 35 |
| Cortech | CRTQ | 5.875 | 7.875 | 34.04 |
| Neurocrine Biosci | NBIX | 24.75 | 33.125 | 33.84 |
| Xenova Group | XNVA | 1.125 | 1.5 | 33.33 |
| Trinity Bio | TRIB | 1.688 | 2.25 | 33.29 |
| Genz Mol Oncol | GZMO | 7 | 9.188 | 31.26 |
| Vion Pharma | VION | 6.125 | 8 | 30.61 |
| ViroLogic | VLGC | 7 | 9.125 | 30.36 |
| Sangamo | SGMO | 15 | 19.5 | 30 |
| NeoRx Corp. | NERX | 4.063 | 5.25 | 29.21 |
| Alkermes | ALKS | 24.562 | 31.375 | 27.74 |
| Epitope | EPTO | 6.5 | 8.25 | 26.92 |
| Visible Genetics | VGIN | 30 | 37.75 | 25.83 |
| Neurobio Tech | NTII | 3.188 | 4 | 25.49 |
| Genta | GNTA | 6.438 | 8 | 24.26 |
| Matritech | NMPS | 3.313 | 4.094 | 23.57 |
| Magainin | MAGN | 1.813 | 2.219 | 22.39 |
| Geron | GERN | 12.625 | 15.438 | 22.28 |
| Adv Tissue Sci | ATIS | 2.5 | 3.031 | 21.24 |
| Genentech | DNA | 67.25 | 81.5 | 21.19 |
| Esperion | ESPR | 9 | 10.875 | 20.83 |
| Biopure | BPUR | 16.625 | 20 | 20.3 |
| Aurora Bioscience | ABSC | 26.5 | 31.438 | 18.63 |
| Aphton | APHT | 15.25 | 18 | 18.03 |
| Alliance | ALLP | 7.375 | 8.625 | 16.95 |
| Rosetta | RSTA | 14 | 16 | 14.29 |
| Genzyme Trans | GZTC | 12.625 | 14.313 | 13.37 |
| Exelixis | EXEL | 13 | 14.625 | 12.5 |
| Aastrom Biosci | ASTM | 0.781 | 0.875 | 12.04 |
| Immunex | IMNX | 36.5 | 40.625 | 11.3 |
| InSite Vision | ISV | 2.75 | 3 | 9.09 |
| ILEX Oncology | ILXO | 24.125 | 26.313 | 9.07 |
| Ligand | LGND | 12.875 | 14 | 8.74 |
| Texas Biotech | TXB | 7.938 | 8.59 | 8.21 |
| Repligen | RGEN | 3.125 | 3.375 | 8 |
| Viragen | VRA | 1.219 | 1.313 | 7.71 |
| Ista Pharma | ISTA | 10.5 | 11.25 | 7.14 |
| Amgen | AMGN | 60.063 | 63.938 | 6.45 |
| Guilford Pharm | GLFD | 17 | 18 | 5.88 |
| VaxGen | VXGN | 18.5 | 19.5 | 5.41 |
| Chiron | CHIR | 42.375 | 44.5 | 5.01 |
| BioTransplant | BTRN | 8.375 | 8.688 | 3.74 |
| Organogenesis | ORG | 8.688 | 8.99 | 3.48 |
| Martek Bio | MATK | 12 | 12.25 | 2.08 |
| Regeneration | RTIX | 14 | 14.25 | 1.79 |
| Keryx | KERX | 10 | 10.125 | 1.25 |
| Epimmune | EPMN | 2.594 | 2.625 | 1.2 |
| GenVec | GNVC | 9.5 | 9.5 | 0 |
| NABI | NABI | 4.625 | 4.625 | 0 |
| Notes: Public biotechnology companies are listed on U.S. stock exchanges. Prices are denoted in U.S. dollars and reflect stock splits where applicable. | ||||
