STOCKS THAT LOST VALUE
| Company Name | Symbol | 12/31/1999 | 12/31/00 | %YTD |
| 3D Pharma | DDDP | 15 | 14.81 | -1.25 |
| Cytoclonal Pharma | CYPH | 7.5 | 7.375 | -1.67 |
| Pharmacopeia | PCOP | 22.625 | 21.81 | -3.59 |
| Genomic Solutions | GNSL | 8 | 7.63 | -4.69 |
| Northfield Labs | NFLD | 11.063 | 10.5 | -5.09 |
| Transkaryotic | TKTX | 38.5 | 36.438 | -5.36 |
| Telik | TELK | 7 | 6.625 | -5.36 |
| Amylin | AMLN | 8.344 | 7.875 | -5.62 |
| Sheffield | SHM | 5 | 4.688 | -6.24 |
| Collateral Thera | CLTX | 19.125 | 17.688 | -7.51 |
| Cholestech | CTEC | 6.5 | 6 | -7.69 |
| Tularik | TLRK | 32.37 | 29.438 | -9.06 |
| Cytogen | CYTO | 2.594 | 2.344 | -9.64 |
| Affymetrix | AFFX | 84.844 | 74.438 | -12.26 |
| Introgen | INGN | 8 | 7 | -12.5 |
| AVI BioPharma | AVII | 5.438 | 4.75 | -12.65 |
| MedImmune | MEDI | 55.292 | 47.688 | -13.75 |
| Arena | ARNA | 18 | 15.5 | -13.89 |
| Variagenics | VGNX | 14 | 11.844 | -15.4 |
| Hyseq | HYSQ | 17 | 14.375 | -15.44 |
| Biotime | BTX | 8.875 | 7.5 | -15.49 |
| Boston Life | BLSI | 3.625 | 3.063 | -15.5 |
| Epix Medical | EPIX | 10 | 8.375 | -16.25 |
| Emisphere | EMIS | 30.063 | 25 | -16.84 |
| Pharmacyclics | PCYC | 41.25 | 34.25 | -16.97 |
| Ciphergen | CIPH | 16 | 13.25 | -17.19 |
| BioMarin | BMRN | 11.75 | 9.688 | -17.55 |
| Axonyx | AXYX | 8 | 6.375 | -20.31 |
| CytRx | CYTR | 0.906 | 0.719 | -20.64 |
| Valentis | VLTS | 9 | 7.125 | -20.83 |
| Versicor | VERS | 11 | 8.625 | -21.59 |
| CuraGen Corp. | CRGN | 34.875 | 27.313 | -21.68 |
| Diacrin | DCRN | 6.5 | 5 | -23.08 |
| V.I. Technologies | VITX | 6.875 | 5.25 | -23.64 |
| Synaptic Pharma | SNAP | 6.75 | 5.125 | -24.07 |
| Select Therapeutics | XZL | 2.312 | 1.75 | -24.31 |
| Lexicon | LEXG | 22 | 16.625 | -24.43 |
| Kosan | KOSN | 14 | 10.5 | -25 |
| Ortec Int'l | ORTC | 7.5 | 5.625 | -25 |
| Diversa | DVSA | 24 | 17.938 | -25.26 |
| Genelabs | GNLB | 5.5 | 4.094 | -25.56 |
| Pharmos | PARS | 2.156 | 1.594 | -26.07 |
| OraPharma | OPHM | 18 | 13.25 | -26.39 |
| Calypte Biomed | CALY | 1.406 | 1.031 | -26.67 |
| DepoMed | DMI | 6 | 4.375 | -27.08 |
| Biogen | BGEN | 84.5 | 60.063 | -28.92 |
| Transgene | TRGNY | 10 | 7 | -30 |
| Transgenomic | TBIO | 15 | 10.5 | -30 |
| Deltagen | DGEN | 15 | 10.438 | -30.41 |
| Gene Logic | GLGC | 26.5 | 18.375 | -30.66 |
| EntreMed | ENMD | 25.625 | 17.25 | -32.68 |
| Avigen | AVGN | 31 | 20.75 | -33.06 |
| Synsorb Biotech | SYBB | 1.875 | 1.25 | -33.33 |
| Genset | GENXY | 19.063 | 12.625 | -33.77 |
| MediChem | MCLS | 7 | 4.625 | -33.93 |
| Immucell | ICCC | 2.375 | 1.563 | -34.19 |
| SciClone | SCLN | 6.125 | 4 | -34.69 |
| Cel-Sci | CVM | 2.313 | 1.5 | -35.15 |
| InFormax | INMX | 16 | 10.375 | -35.16 |
| IntraBiotics | IBPI | 15 | 9.625 | -35.83 |
| British Biotech | BBIOY | 4.5 | 2.813 | -37.49 |
| Atherogenics | AGIX | 8 | 5 | -37.5 |
| Compugen | CGEN | 10 | 6.25 | -37.5 |
| Vical | VICL | 29.938 | 18.5 | -38.21 |
| MacroChem | MCHM | 4.188 | 2.563 | -38.8 |
| Nexell | NEXL | 5 | 3.031 | -39.38 |
| Immune Resp | IMNR | 4.344 | 2.625 | -39.57 |
| Zonagen | ZONA | 4.375 | 2.625 | -40 |
| Envirogen | ENVG | 1.688 | 1 | -40.76 |
| Dusa Pharma | DUSA | 28.5 | 16.813 | -41.01 |
| deCODE | DCGN | 18 | 10.5 | -41.67 |
| Columbia Labs | COB | 7.5 | 4.313 | -42.49 |
| Avax Technologies | AVXT | 6.594 | 3.75 | -43.13 |
| Argonaut | AGNT | 15 | 8.5 | -43.33 |
| Large Scale | LSBC | 17 | 9.5 | -44.12 |
| Enzo Biochem | ENZ | 46 | 24.875 | -45.92 |
| Ergo Science | ERGO | 1.188 | 0.625 | -47.39 |
| Aclara Bioscience | ACLA | 21 | 10.875 | -48.21 |
| Cell Pathways | CLPA | 9.25 | 4.75 | -48.65 |
| Interleukin | ILGN | 6.219 | 3.188 | -48.74 |
| Cantab Pharm | CNTBY | 10.75 | 5.5 | -48.84 |
| Carrington | CARN | 2 | 1 | -50 |
| Questcor Pharm | QSC | 1.25 | 0.625 | -50 |
| Cyanotech | CYAN | 1.563 | 0.781 | -50.03 |
| Celera | CRA | 74.5 | 36.125 | -51.51 |
| QLT PhotoTher | QLTI | 58.75 | 28 | -52.34 |
| Pharsight | PHST | 10 | 4.75 | -52.5 |
| SuperGen | SUPG | 29.375 | 13.875 | -52.77 |
| Microcide Pharma | MCDE | 8.875 | 4.125 | -53.52 |
| Bio-Tech Gen | BTGC | 15.25 | 7.063 | -53.69 |
| Atlantic Pharma | ATLC | 1.438 | 0.656 | -54.38 |
| Allos | ALTH | 18 | 8.063 | -55.21 |
| Connetics Corp. | CNCT | 10.5 | 4.563 | -56.54 |
| Genome Thera | GENE | 16.125 | 6.969 | -56.78 |
| Ostex Int'l | OSTX | 3 | 1.25 | -58.33 |
| Incyte Genomics | INCY | 60 | 24.875 | -58.54 |
| Igen | IGEN | 29.75 | 12.313 | -58.61 |
| Nanogen | NGEN | 21.875 | 9 | -58.86 |
| Gemini Genomics | GMNI | 14 | 5.625 | -59.82 |
| SangStat Med | SANG | 29.75 | 11.875 | -60.08 |
| ViroPharma | VPHM | 37 | 14.469 | -60.89 |
| Triangle Pharma | VIRS | 12.813 | 4.938 | -61.46 |
| OXiGENE | OXGN | 15.625 | 5.875 | -62.4 |
| Endorex | DOR | 2.75 | 1 | -63.64 |
| Trega Biosciences | TRGA | 2.344 | 0.844 | -63.99 |
| Osteotech | OSTE | 13.375 | 4.75 | -64.49 |
| Progenics Pharma | PGNX | 48.875 | 17.25 | -64.71 |
| Maxygen | MAXY | 71 | 24.5 | -65.49 |
| Immtech | IMMT | 28.875 | 9.75 | -66.23 |
| Cypress Bio | CYPB | 1.813 | 0.594 | -67.24 |
| Curis | CRIS | 27.125 | 8.875 | -67.28 |
| United Thera | UTHR | 46 | 14.75 | -67.93 |
| Maxim Pharma | MAXM | 20 | 6.375 | -68.13 |
| NeoTherapeutics | NEOT | 13.25 | 4.125 | -68.87 |
| Lifecell | LIFC | 5.125 | 1.594 | -68.9 |
| AMBI | AMBI | 2.469 | 0.75 | -69.62 |
| Insmed | INSM | 11.5 | 3.469 | -69.83 |
| Genetronics | GEB | 3.25 | 0.938 | -71.14 |
| Lynx Therapeutics | LYNX | 32.375 | 9 | -72.2 |
| Genomica | GNOM | 19 | 5.281 | -72.21 |
| Cygnus | CYGN | 18.25 | 4.875 | -73.29 |
| Sonus Pharma | SNUS | 2.5 | 0.625 | -75 |
| Gliatech | GLIA | 16.625 | 4.063 | -75.56 |
| Oxis Int'l | OXIS | 1.594 | 0.375 | -76.47 |
| BioCryst | BCRX | 29.5 | 6.625 | -77.54 |
| Interneuron | IPIC | 5.719 | 1.281 | -77.6 |
| Lifecore Bio | LCBM | 21.125 | 4.625 | -78.11 |
| Immucor | BLUD | 13.188 | 2.688 | -79.62 |
| Synbiotics | SBIO | 2.406 | 0.438 | -81.8 |
| Antigenics | AGEN | 61.375 | 11.063 | -81.97 |
| Sequenom | SQNM | 79.25 | 14 | -82.33 |
| Biora AB | BIORY | 9 | 1.438 | -84.02 |
| CollaGenex | CGPI | 25 | 3.688 | -85.25 |
| GalaGen | GGEN | 1.813 | 0.25 | -86.21 |
| ImmuLogic | IMUL | 0.563 | 0.06 | -89.34 |
| Ecogen | EECN | 1.25 | 0.12 | -90.4 |
| HeavenlyDoor | HVDC | 3.688 | 0.063 | -98.29 |
| Notes: Public biotechnology companies are listed on U.S. stock exchanges. Prices are denoted in U.S. dollars and reflect stock splits where applicable. | ||||