Published April 15 & 22 (EPO); April 9 & 16 (WO); April 22 (GB)
Abbott Labs WO 98/1565 Prostate-specific genes Abbott Park, Ill. Prostate-specific genes, mRNAs, encoded proteins, antibodies; for prostate cancer diagnosis and therapy.
Adv. Res. & Technol. Inst. WO 98/14567 Antibacterial oligos Bloomington, Ind. Oligos targeted to the Shine-Dalgarno region of prokaryote genes; for inhibiting bacterial protein expression.
Amgen WO 98/14598 ICE-like cysteine proteases Thousand Oaks, Calif. Interleukin-beta converting enzyme (ICE)-like cysteine protease, encoding gene; for identifying modulators.
Arch Devlop. WO 98/15575 Restenosis inhibition Chicago, Ill. Smooth muscle cell-specific promoter; for treating restenosis by expressing cell cycle genes using this promoter.
Bayer WO 98/15625 Parasitic nematode drugs Leverkusen, Germany Open chain depsipeptides, encoding genes; for identifying agents that affect parasitic nematodes.
Becton Dickinson WO 98/14561 Dendritic cell precursor isolation Franklin Lakes, N.J. Identification of CD34+ bone marrow cells that are precursors to dendritic cells; isolation methods.
Becton Dickinson WO 98/14783 Hematopoietic stem cell separation Franklin Lakes, N.J. Separation of monocyte and granulocyte cell lineages using M-CSF and antibodies to this colony stimulating factor.
Biotherapies WO 98/14577 Mammastatin Ann Arbor, Mich. Gene for mammastatin, encoded protein; for inhibiting mammary cancer and metastasis.
Bloch, D.B., et al. WO 98/14569 Leukocyte-specific gene Newton, Mass. Leukocyte-specific gene, encoded protein resembling a transcription factor; for autoimmune disease.
Boehringer Mannheim WO 98/15580 ACT/serine protease complex antibodies Mannheim, Germany Monoclonal antibodies to human ACT and serine protease complex; for diagnostic detection of complexes.
Brax Genomics WO 98/15651 Target mRNA antisense Cambridge, U.K. Method for identifying antisense probes from an oligo library that bind to a specified target mRNA.
Bujard, H. WO 98/14583 Malaria vaccine Heidelberg, Germany Plasmodium falciparum cell surface antigen, encoding gene, production method; for use as a vaccine.
California, Univ. of WO 98/14058 Cell cryopreservation method Oakland, Calif. Cryopreservation of human pancreatic cells and platelets using trehalose and dimethyl sulfoxide.
California, Univ. of WO 98/14613 Pathogen infection therapeutics Oakland, Calif. Pathogenic infection treatment using agents that interfere with extracellular enzymes necessary for growth.
Canterbury Health WO 98/15579 Dendritic cell antigen antibodies Christchurch, New Zealand Monoclonal antibodies to an activation antigen on dendritic cells; for cell purification.
Celltech Therapeutics WO 98/14211 Th2 cell differentiation Slough, U.K. Protein-tyrosine kinase p56lck inhibitor combined with an anti-CD4 antibody; for differentiation of Th2 cells.
Ctr. Genetic Engin. & Biotech. WO 98/14566 Cancer therapeutics Havana, Cuba Genetically engineered microorganisms that produce antitumor molecules; for cancer therapy.
Ctr. Genetic Engin. & Biotech. WO 98/14600 Yeast production system Havana, Cuba Genetically engineered yeast that use the sucrose invertase gene to direct recombinant protein production.
Cheil Jedang WO 98/14585 Hemorrhagic fever vaccine Seoul, S. Korea Gene for Seoul R22 strain Hantavirus nucleocapsid, encoded protein, expression system; for treating hemorrhagic fever.
Chugai WO 98/14580 Humanized antibody Tokyo Reconstituted, humanized anti-HM1.24 antibody; for less immunogenic therapy.
Cleveland Clinic Fdn. WO 98/14218 RNase L transgenics Cleveland, Ohio Transgenics with a disrupted RNase L gene; for assessing the effects of antiviral drugs on this enzyme.
Connaught Labs WO 98/15635 Pox virus cancer vaccine North York, Ontario Recombinant canarypox virus having foreign genes; for immunization and treating tumor cells in vivo.
Cornell Univ. WO 98/15289 Kaposi's herpesvirus treatment Ithaca, N.Y. Genes from Kaposi's sarcoma-associated herpesvirus, encoded proteins, oligos, antibodies; for treatment.
Dako WO 98/15648 Mycobacterial infection probes Glostrup, Denmark Nucleic acid probes for mycobacterial ribosomal DNA and RNA; for diagnosing infection.
Dana-Farber Cancer Inst. WO 98/14207 Immunological cancer therapy Boston Use of tissue-specific antigens to mount an immune response against a solid tumor lodged in that tissue.
Dana-Farber Cancer Inst. WO 98/15569 HIV entry inhibitors Boston Binding assays for molecules affecting HIV gp120 binding to CD4 receptors; for HIV treatment.
Diapharm GB 2 318 352 Erythropoietin muteins St. Peter Port, U.K. Erythropoietin muteins that mimic natural activity but have different amino acid sequences.
Duff, G,. et al. WO 98/15653 Diabetic retinopathy polymorphism Sheffield, U.K. Probes for the genetic polymorphisms associated with a predisposition to diabetic retinopathy; for diagnosis.
Duke Univ. WO 98/15615 Dendritic cell development Durham, N.C. Production of an in vitro thymic microenvironment that supports dendritic cell development; for HIV treatment.
Embrex WO 98/14212 Pathogen neutralizing vaccine Research Triangle Park, N.C. Live bacteria or protozoa with a bound neutralizing antibody; for vaccination.
Fordham Univ. WO 98/15616 Cytotoxic T cell generation Bronx, N.Y. Co-culture of immune cells and antigenic cells treated with osmotic shock and radiation; for making cytotoxic T cells.
Franconi Anemia Res. Fund WO 98/14462 Franconi anemia gene Eugene, Ore. Gene associated with Franconi anemia complementation group A; for diagnosis and treatment.
Garoff, H., et al. WO 98/15636 Alphavirus retroviral vectors Huddinge, Sweden Alphavirus retroviral vectors; for introducing RNA coding sequences directly into cell cytoplasm.
Genentech WO 98/14475 Smoothened genes S. San Francisco Human and rat genes homologous to the smoothened gene, encoded proteins, chimeric proteins, antibodies.
Genetics Inst. WO 98/14470, 14575, 14576 Secreted protein genes Cambridge, Mass. Genes encoding secreted proteins, encoded proteins, vectors; for identifying secreted protein genes.
Geron WO 98/14592 & 14593 Telomerase Menlo Park, Calif. Genes for telomerase and its subunits from various species, encoded proteins, functional fragments, ribonucleoproteins.
Gynecol. & Obstet. Res. Fdn. WO 98/15631 Bacterial HPV vaccine Lausanne, Switzerland Attenuated Salmonella strains expressing human papillomavirus (HPV) genes and virus-like particles; for vaccines.
Hanil Synthetic Fiber WO 98/14591 Soluble recombinant bacterial proteins Masan, S. Korea Production of soluble recombinant proteins in E. coli using the lysyl tRNA synthetase gene.
Hart, D.N.J. WO 98/14562 Immunosuppressant identification Christchurch, New Zealand Gene for a protein with S-adenosyl-L-homocysteine hydrolase activity, encoded enzyme; for finding immunosuppressants.
Harvard Univ. WO 98/15576 Platelet secretory transport protein Cambridge, Mass. Platelet secretory transport protein, encoding gene, antibodies; for targeting activated platelets.
Hisamitsu Pharma EPO 837 074 Metastasis-inhibiting fibronectin fragment Tosu, Japan Biologically active fibronectin fragment that inhibits cell adhesion; for treating cancer metastasis.
Hoechst EPO 835 939 Immunoglobulin fusion proteins Frankfurt, Germany Fusion proteins with immunoglobulin constant region domains, production methods [in German].
Human Genome Sciences WO 98/14582 White cell inhibitory factors Rockville, Md. Genes for myeloid progenitor, monocyte colony, and macrophage inhibitory factors, encoded proteins, therapeutics.
Human Genome Sciences WO 98/15624 Galectins Rockville, Md. Genes for galectins, encoded proteins, production methods; for identifying modulators.
Hunan Med. Univ. EPO 837 127 Hereditary bony outgrowths Changsha, China Gene associated with hereditary multiple bony outgrowths, encoded protein; for treating this disease and cancers.
Immunex WO 98/14565 Apoptosis-inducing receptors Seattle, Wash. Genes for apoptosis-inducing receptors, encoded proteins; for screening inhibitors and regulating immune response.
Incyte WO 98/14570 ATPase inhibitor Palo Alto, Calif. Gene for a human ATPase inhibitor, encoded protein, antisense, antibodies, antagonists, expression system.
Incyte WO 98/14571 Sulfonylurea receptor Palo Alto, Calif. Gene for human sulfonylurea receptor, encoded protein, antisense, antibodies, antagonists, expression system.
Incyte WO 98/14572 Phospholemman-like protein Palo Alto, Calif. Gene for human phospholemman-like protein, encoded protein, antisense, antibodies, antagonists, expression system.
Incyte WO 98/14596 Protein tyrosine phosphatases Palo Alto, Calif. Genes for protein tyrosine phosphatases, encoded proteins, antibodies, antisense, antagonists; for therapeutics.
Incyte WO 98/14619 Transcript marker analysis Palo Alto, Calif. Methods and vectors for constructing transcript marker libraries and high-throughput transcript extension.
Incyte WO 98/15632 Protein tyrosine kinase Palo Alto, Calif. Gene for a human protein tyrosine kinase, encoded protein, antibodies, antisense, modulators; for therapeutics.
Inspire Pharma WO 98/15835 Lung cancer assay Durham, N.C. Uridine 5'-triphosphate induction of lung sputum samples; for detecting lung cancer antigens or gene mutations.
Inst. Child Health WO 98/15626 Xenograft enhancement London Mutated gene for class II transactivator, encoded protein; for reduced MHC class II antigen expression in xenografting.
Isis Pharma WO 98/14615 Multidrug resistance gene oligos Carlsbad, Calif. Oligos that hybridize with the multidrug resistance gene; for preventing tumor resistance to chemotherapy.
Italian Pharmacotherapy Inst. WO 98/15282 Immunogenic TLP Rome, Italy Immunogenic TLP; for treating non-squamous cell lung carcinoma and urogenital cancer.
Japan Sci. & Technol. WO 98/15173 Rheumatoid arthritis model Saitama, Japan Mice that exhibit a spontaneous onset of rheumatoid arthritis-like symptoms; for use as a model.
La Jolla Inst. Allergy & Immunol. WO 98/15286 Carbohydrate-specific cytolytic T cells San Diego Immunogenic protein that binds to an MHC class I molecule and stimulates T cells with an attached carbohydrate.
Leukosite WO 98/14480 C-C chemokine receptor 3 Cambridge, Mass. Gene for C-C chemokine receptor 3, encoded protein, inhibitors, production methods; for modifying leukosite function.
Lexicon Genetics WO 98/14614 Gene mutation cell library The Woodlands, Texas Methods and vectors for constructing a library of cells with gene mutations; for making transgenics.
Lilly EPO 835 879 Anti-obesity therapeutics Indianapolis, Ind. Soluble variants of anti-obesity proteins based on chimpanzee leptin; for therapeutics.
Loma Linda Univ. WO 98/14605 Fusion reporter gene Loma Linda, Calif. Fusion of luciferase and humanized green fluorescent protein, encoding gene; for use as a reporter gene.
Ludwig Inst. Cancer Res. WO 98/14463 Tumor rejection antigen precursor New York Genes for MAGE-10 tumor rejection antigen precursor, encoded protein, antibodies; for treating cancer.
Ludwig Inst. Cancer Res. WO 98/15638 Cancer-associated antigen New York Gene for a cancer-associated antigen, encoded protein; for cancer diagnostics and therapeutics.
Ludwig Inst. Cancer Res. WO 98/14464 Tumor rejection antigen vaccines New York Replication-defective adenoviruses with tumor rejection antigen precursor genes; for inducing immune responses.
Massachusetts, Univ. Med. Sch. WO 98/15629 Phosphatidylinositide binding proteins Worcester, Mass. Phosphatidylinositide binding proteins, encoding gene, antisense, transgenics; for mediating cell signalling.
Mass. Gen. Hosp. WO 98/14573 Monocyte chemotactic proteins Boston Genes for monocyte chemotactic proteins, encoded proteins; for modulating immune responses.
Maudsley, D.J. WO 98/14205 Cancer gene therapy Kenilworth, U.K. Cancer vaccines vectors encoding a foreign MHC molecule and an oncogene product.
Max Planck Inst. EPO 835 928 Helicobacter vaccine Munich, Germany Recombinant live vaccines against Helicobacter pylori, screening method; for treating ulcers.
MRC (Med. Res. Counc.) WO 98/15618 Stress-activated protein kinase London Gene for a stress-activated protein kinase, encoded protein, variants, fragments, fusions, derivatives; for drug screens.
Merck WO 98/14564 HPV-16 virus-like particles Rahway, N.J. Synthetic human papillomavirus (HPV)-16 virus-like particles; for diagnosing infection.
Merck WO 98/14586 Herpes DNA vaccine Rahway, N.J. Polynucleotide vaccine against herpes simplex that is expressed after injection into muscle tissue.
Millennium WO 98/14579 RATH genes Cambridge, Mass. RATH genes, encoded proteins; for regulating G-protein-mediated signal transduction in T cell activation.
Mulvany, M., et al. WO 98/15623 Hypertension markers Aarhus, Denmark Use of marker proteins and genes to detect genetic predisposition to hypertension.
NIH (Natl. Inst. Hlth.) WO 98/14469 Precancerous state protein Bethesda, Md. Gene for an epithelial cell protein whose presence is indicates a precancerous state, encoded protein; for detection.
NIH (Natl. Inst. Hlth.) WO 98/14472 Malarial fusion protein antigens Bethesda, Md. Pfs28 fusion proteins; for eliciting an immunogenic response to malarial parasites.
NIH (Natl. Inst. Hlth.) WO 98/14587 HIV infection inhibition Bethesda, Md. Soluble HIV transcativator Tat protein analogs and their encoding genes; for inhibiting HIV infection.
New York Univ. EPO 835 932 Non-glycosylated FGF-4 New York Non-glycosylated fibroblast growth factor-4, production methods; for treating soft tissue injuries.
North Carolina, Univ. of WO 98/14471 Platelet calcium-binding protein Chapel Hill, N.C. Calcium-binding protein expressed in platelets that interacts with fibrinogen receptor and integrin aIIb subunits.
Northwestern Univ. WO 98/15574 Angiogenesis inhibition Evanston, Ill. Generation of angiostatin in vivo using plasminogen binding, plasminogen fragments that inhibit angiogenesis.
Novo Nordisk EPO 837 072 Human insulin analogs Bagsvaerd, Denmark Human insulin analogs with a lysine or arginine at amino acid residue 28 in the B chain and other substitutions.
Oklahoma Med. Res. Fdn. WO 98/14574 Elongin functional domains Oklahoma City, Okla. Functional domains of elongin A and C; for modulating elongin binding and activation.
Pasteur Inst. WO 98/15172 Neuronal deficit transgenics Paris Transgenics deficient in genes involved in neuron survival; for identifying agents that enhance neuron maintenance.
Phytera WO 98/14784 Multidrug resistance inhibitors Worcester, Mass. Mutant cells containing a dysfunctional multidrug resistance pump; for identifying inhibitors.
Pittsburgh, Univ. of WO 98/15637 Herpes simplex virus vectors Pittsburgh Herpes simplex virus strains with mutations in the early genes; for expressing exogenous genes.
Probe Intl. WO 98/15658 Viral antibody therapeutics Shreveport, La. Antibodies to viral proteins that cause inactivation and loss of infectivity; for HIV therapy.
Progenitor WO 98/14466 Hemochromatosis polymorphic sites Menlo Park, Calif. Polymorphic sites in the region of the human hemochromatosis gene; for diagnostic assays.
Rappold-Hoerbrand, G. WO 98/14568 Short stature gene region Heidelberg, Germany Gene associated with short stature and found on the sex chromosomes, encoded homeobox domain-containing protein.
Schering WO 98/15834 CC/CXC chemokines Kenilworth, N.J. Genes for mouse and human CC and CXC chemokines, encoded proteins, antibodies; for diagnostics.
Schering WO 98/14581 p53 antibody biosensor Kenilworth, N.J. Detection of antibodies that bind p53 protein using a surface plasmon resonance biosensor with immobilized p53.
Scios WO 98/15828 ß-APP formation inhibitors Mountain View, Calif. Cell line expressing beta-amyloid precursor protein (beta-APP); for finding inhibitors of beta-APP forming gamma-secretase.
Signal Pharma WO 98/14609 Cytomegalovirus infection treatment San Diego Agents that inhibit the cell-type specific transactivation of the human cytomegalovirus DNA polymerase gene.
SmithKline Beecham EPO 835 933 G-protein coupled receptor Philadelphia Gene for a G-protein coupled receptor, HLTEX11, encoded protein, production methods; for inflammation.
SmithKline Beecham EPO 835 936 Arginyl tRNA synthase Brentford, U.K. Gene for arginyl tRNA synthase, encoded protein; for antibacterial screen.
SmithKline Beecham EPO 835 937 Human Myt-1 kinase Philadelphia Gene for human Myt-1 kinase, encoded protein, production methods; for treating cancer and inflammation.
SmithKline Beecham EPO 835 938 & 837 136 Topoisomerase I Philadelphia Gene for topoisomerase I, encoded protein, production methods; for treating bacterial infections.
SmithKline Beecham EPO 837 073 Human MAD proteins Philadelphia Genes for human MAD proteins, encoded proteins, production methods, modulators; for wound and cancer treatments.
SmithKline Beecham EPO 837 128 G-protein coupled receptor Philadelphia Gene for a G-protein coupled receptor, HLYAZ61, encoded protein, production methods; for infection and cancer.
SmithKline Beecham EPO 837 130 Staphylococcus infection treatment Philadelphia Gene for Staphylococcus pneumoniae M protein, encoded protein; for diagnosing and treating bacterial infections.
SmithKline Beecham EPO 837 131 Staphylococcus antibacterials Philadelphia Gene for Staphylococcus fibronectin binding protein A, encoded peptides, production methods; for antibacterials.
SmithKline Beecham EPO 837 133 Resolvase antibacterials Philadelphia Genes for resolvase family DNA strand resolution proteins, encoded proteins, production methods; for antibacterials.
SmithKline Beecham EPO 837 137 & 837 138 Topoisomerase III Philadelphia Gene for topoisomerase III, encoded protein, production methods; for treating bacterial infections.
SmithKline Beecham EPO 837 142 Identifying pathogenicity genes Philadelphia Vector with a promoter activated selectively during infection; for identifying essential pathogenicity genes.
SmithKline Beecham WO 98/14461 & 14563 Antibacterial therapy Brentford, U.K. Genes for spsB polypeptides, encoded proteins, antagonists; for diagnosis and treatment of bacterial infections.
South Alabama Med. Sci. Fdn. WO 98/14606 Protein phosphatase inhibitors Mobile, Ala. Use of the protein phosphatase inhibitor, fostriecin, to reduce cell damage after a heart attack.
Southampton, Univ. of WO 98/15627 Fish expression system Southampton, U.K. Vector designed for expressing recombinant proteins in transgenic fish.
SRL WO 98/15654 Mutation detection vector Tokyo Detection of nonsense and frameshift mutations using an expression vector with a reporter gene.
Sumitomo Electric EPO 837 129 Epimorphin antagonist Osaka, Japan Epimorphin functional domain; for use as an epimorphin antagonist inhibiting epithelial cell morphogenesis.
Sumitomo Pharma WO 98/15628 Semaphorin W Osaka, Japan Gene for semaphorin W, encoded protein, antibodies, antisense; for inhibiting nerve extension.
Synaptic Pharma WO 98/15570 Galanin receptors Paramus, N.J. Genes for galanin receptors, encoded proteins, antisense, antibodies; for identifying modulators.
Thomas Jefferson Univ. WO 98/14206 Tumor-associated T cells Philadelphia Expansion of tumor-associated T cells; for mediating tumor regression.
Utrecht Univ. WO 98/15833 Phage display binding library Utrecht, Netherlands Phage display, in tissue sections or solid phase, of a library of proteins that potentially bind to targets.
Vitality Biotech WO 98/15567 Transgenic synthetic genes Tirat Hacarmel, Israel Construction of synthetic genes with preferred codons for transgenics.
Vlaams Univ. Inst. Biotech. WO 98/15650 Hydronephrosis gene Zwijnaarde, Belgium Hydronephrosis gene that is associated with renal diseases; for diagnosis.
Washington, Univ. of WO 98/15179 Laminin in Alzheimer's Seattle, Wash. Use of laminin, laminin-derived proteins, and antibodies to diagnose and treat Alzheimer's disease.
Wisconsin, Univ. of WO 98/15634 Mammary gland-specific promoter Madison, Wis. Mammary gland-specific promoter that causes constant gene expression during the estrous cycle.
Wistar Inst. WO 98/15285 p53 cancer vaccine Philadelphia Cancer vaccine having genes encoding an inactive form of p53 or a p53 antigen fusion protein; for cancer therapy.
Yale Univ. WO 98/14584 Granulocytic ehrlichiosis proteins New Haven, Conn. Genes for human granulocytic ehrlichiosis-associated proteins, encoded proteins, antibodies; for diagnosis.
Yeda Res. & Devlop. EPO 835 661 Human beta-interferons Rehovot, Israel Genes for human beta-interferons, encoded proteins, production methods; for cell growth and treating cancer.
-- Compiled by Chester A. Bisbee