Issued Feb. 12 by the U.S. Patent and Trademark Office

U.S. Class: 424-64.63Patent Number: 4,992,274Assignee: Beecham Group plcClaims/Description: 6 claims for a hybrid protein, composed ofthe A chain from tissue plasminogen activator and the B chainfrom urokinase.

U.S. Class: 424-85.2Patent Number: 4,992,271Assignee: Cetus Corp.Claims/Description: 8 claims for a stable pharmaceuticalpreparation of biologically active, non-glycosylated IL-2.

U.S. Class: 424-89Patent Number: 4,992,273Assignee: Institut PasteurClaims/Description: 10 claims for antigens isolated fromLeishmania parasites. Such antigens may be suitable forinducing protective antibodies in mice.

U.S. Class: 435-6Patent Number: 4,992,364Assignee: Institut Pasteur and INSRClaims/Description: 11 claims for a DNA probe and its use indetecting microbes that cause diarrhea.

U.S. Class: 435-69.52Patent Number: 4,992,367Assignee: Hoffmann-La RocheClaims/Description: 11 claims for enhanced expression ofhuman IL-2 in mammalian cells.

U.S. Class: 435-226Patent Number: 4,992,373Assignee: Eli Lilly & Co.Claims/Description: 17 claims for DNA sequences that encodeactivated human protein C, and for the vector systems thatexpress that protein.

U.S. Class: 435-235.1Patent Number: 4,992,375Assignee: Monsanto Co.Claims/Description: 10 claims for a method to regeneratesoybean plants from callus cultures.

U.S. Class: 435-320.1Patent Number: 4,992,378Assignee: McGill UniversityClaims/Description: 3 claims for a c-DNA sequence to encodethe human prolactin receptor.U.S. Class: 530-307Patent Number: 4,992,530Assignee: Toyo JozoClaims/Description: 1 claim for peptide analogs of thecalcitonin-gene-related peptide.

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