Alentis Therapeutics SA has closed a $105 million series C round which will fund simultaneous phase II and phase Ib trials of anti-Claudin-1 antibodies in the treatment of organ fibrosis and phase I development in fibrosis-associated cancers. At the same time, the company will extend the reach of its Claudin-1 biology into antibody-drug conjugates and bispecific constructs, to further exploit the role of the transmembrane protein in maintaining cellular integrity and controlling cell-to-cell signaling.