Ebola virus (EBOV) causes severe febrile illness that frequently leads to death within 10 days of infection due to multiorgan failure. Different therapeutic strategies have been developed against EBOV infection, including small-molecule drugs, monoclonal antibodies and viral vaccine vectors. Despite their promise, all these strategies have significant limitations that limit their clinical application. Researchers from Mayo Clinic recently presented a novel molecular therapy, which they called “therapeutic minigenome,” using EBOV’s own proteins to combat itself.